Effect of aerobic exercise on some factors of cardiac apoptosis in male rats
Background: Cardiac apoptosisplays an important role in myocardial diseases. Current evidence suggests that exercise training may modify some apoptosis-related signaling in myocardium. This study aimedto investigate the effect of aerobic training on cardiac Bax, Bcl2 and caspase-3 inmale rats. Mate...
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| Format: | Article |
| Language: | fas |
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Kashan University of Medical Sciences and Health Services
2019-12-01
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| Series: | Fiyz̤ |
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| Online Access: | http://feyz.kaums.ac.ir/article-1-3792-en.html |
| _version_ | 1811318673942511616 |
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| author | Sadighi A Abdi A Azarbayjani MA Barari AR |
| author_facet | Sadighi A Abdi A Azarbayjani MA Barari AR |
| author_sort | Sadighi A |
| collection | DOAJ |
| description | Background: Cardiac apoptosisplays an important role in myocardial diseases. Current evidence suggests that exercise training may modify some apoptosis-related signaling in myocardium. This study aimedto investigate the effect of aerobic training on cardiac Bax, Bcl2 and caspase-3 inmale rats.
Materials and Methods: In this experimental study, Sixteen Wistar male rats 10 weeks old with 299.74±19.32 g weight were randomly classified into control and training groups. Training groups have performed an aerobic running program (at 10-18 m/min, 10-40 min/day, and 5 days/week) on a motor-driven treadmill for six weeks.Forty eight hours after the last training session, rats were sacrificed; hearts were excised and immediately frozen in liquid nitrogen and stored at -80 °C.Bax, Bcl2 and caspase3 protein expression were evaluated by ELISA and western blot. Data were analyzed using Independent t-test and ANCOVA at P<0.05.
Result: The results showed that six weeks aerobic training significantly decreased heart Bax in rats (P=0.045). Also heart Bcl2 (P=0.003) and caspase-3 (P=0.040) were significantly increased in comparison to the training group.
Conclusion: Moderate-intensity aerobic exercise seems to modify some factors affecting the apoptosis of the heart tissue of male rats. |
| first_indexed | 2024-04-13T12:29:47Z |
| format | Article |
| id | doaj.art-44462dc013414b21a238b0e867522f4b |
| institution | Directory Open Access Journal |
| issn | 1029-7855 2008-9821 |
| language | fas |
| last_indexed | 2024-04-13T12:29:47Z |
| publishDate | 2019-12-01 |
| publisher | Kashan University of Medical Sciences and Health Services |
| record_format | Article |
| series | Fiyz̤ |
| spelling | doaj.art-44462dc013414b21a238b0e867522f4b2022-12-22T02:46:53ZfasKashan University of Medical Sciences and Health ServicesFiyz̤1029-78552008-98212019-12-01235495502Effect of aerobic exercise on some factors of cardiac apoptosis in male ratsSadighi A 0Abdi A 1Azarbayjani MA 2Barari AR3Ph.D Candidate in Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, I.R. Iran.Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, I.R. Iran.Department of Exercise Physiology, Faculty of Physical Education and Sports Science, Central Tehran Branch, Islamic Azad University, Tehran, I.R. Iran.Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, I.R. Iran.Background: Cardiac apoptosisplays an important role in myocardial diseases. Current evidence suggests that exercise training may modify some apoptosis-related signaling in myocardium. This study aimedto investigate the effect of aerobic training on cardiac Bax, Bcl2 and caspase-3 inmale rats. Materials and Methods: In this experimental study, Sixteen Wistar male rats 10 weeks old with 299.74±19.32 g weight were randomly classified into control and training groups. Training groups have performed an aerobic running program (at 10-18 m/min, 10-40 min/day, and 5 days/week) on a motor-driven treadmill for six weeks.Forty eight hours after the last training session, rats were sacrificed; hearts were excised and immediately frozen in liquid nitrogen and stored at -80 °C.Bax, Bcl2 and caspase3 protein expression were evaluated by ELISA and western blot. Data were analyzed using Independent t-test and ANCOVA at P<0.05. Result: The results showed that six weeks aerobic training significantly decreased heart Bax in rats (P=0.045). Also heart Bcl2 (P=0.003) and caspase-3 (P=0.040) were significantly increased in comparison to the training group. Conclusion: Moderate-intensity aerobic exercise seems to modify some factors affecting the apoptosis of the heart tissue of male rats.http://feyz.kaums.ac.ir/article-1-3792-en.htmlexercise trainingcardiac diseasecaspase3baxbcl2 |
| spellingShingle | Sadighi A Abdi A Azarbayjani MA Barari AR Effect of aerobic exercise on some factors of cardiac apoptosis in male rats Fiyz̤ exercise training cardiac disease caspase3 bax bcl2 |
| title | Effect of aerobic exercise on some factors of cardiac apoptosis in male rats |
| title_full | Effect of aerobic exercise on some factors of cardiac apoptosis in male rats |
| title_fullStr | Effect of aerobic exercise on some factors of cardiac apoptosis in male rats |
| title_full_unstemmed | Effect of aerobic exercise on some factors of cardiac apoptosis in male rats |
| title_short | Effect of aerobic exercise on some factors of cardiac apoptosis in male rats |
| title_sort | effect of aerobic exercise on some factors of cardiac apoptosis in male rats |
| topic | exercise training cardiac disease caspase3 bax bcl2 |
| url | http://feyz.kaums.ac.ir/article-1-3792-en.html |
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