Concomitant Obesity and Metabolic Syndrome Add to the Atrial Arrhythmogenic Phenotype in Male Hypertensive Rats
BackgroundBesides hypertension, obesity and the metabolic syndrome have recently emerged as risk factors for atrial fibrillation. This study sought to delineate the development of an arrhythmogenic substrate for atrial fibrillation in hypertension with and without concomitant obesity and metabolic s...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-09-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.117.006717 |
| _version_ | 1818398639788130304 |
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| author | Mathias Hohl Dennis H. Lau Andreas Müller Adrian D. Elliott Benedikt Linz Rajiv Mahajan Jeroen M. L. Hendriks Michael Böhm Ulrich Schotten Prashanthan Sanders Dominik Linz |
| author_facet | Mathias Hohl Dennis H. Lau Andreas Müller Adrian D. Elliott Benedikt Linz Rajiv Mahajan Jeroen M. L. Hendriks Michael Böhm Ulrich Schotten Prashanthan Sanders Dominik Linz |
| author_sort | Mathias Hohl |
| collection | DOAJ |
| description | BackgroundBesides hypertension, obesity and the metabolic syndrome have recently emerged as risk factors for atrial fibrillation. This study sought to delineate the development of an arrhythmogenic substrate for atrial fibrillation in hypertension with and without concomitant obesity and metabolic syndrome. Methods and ResultsWe compared obese spontaneously hypertensive rats (SHR‐obese, n=7–10) with lean hypertensive controls (SHR‐lean, n=7–10) and normotensive rats (n=7–10). Left atrial emptying function (MRI) and electrophysiological parameters were characterized before the hearts were harvested for histological and biochemical analyses. At the age of 38 weeks, SHR‐obese, but not SHR‐lean, showed increased body weight and impaired glucose tolerance together with dyslipidemia compared with normotensive rats. Mean blood pressure was similarly increased in SHR‐lean and SHR‐obese when compared with normotensive rats (178±9 and 180±8 mm Hg [not significant] versus 118±5 mm Hg, P<0.01 for both), but left ventricular end‐diastolic pressure was more increased in SHR‐obese than in SHR‐lean. Impairment of left atrial emptying function, increase in total atrial activation time, and conduction heterogeneity, as well as prolongation of inducible atrial fibrillation durations, were more pronounced in SHR‐obese as compared with SHR‐lean. Histological and biochemical examinations revealed enhanced triglycerides and more pronounced fibrosis in the left atrium of SHR‐obese. Besides increased expression of profibrotic markers in SHR‐lean and SHR‐obese, the profibrotic extracellular matrix protein osteopontin was highly upregulated only in SHR‐obese. ConclusionsIn addition to hypertension alone, concomitant obesity and metabolic syndrome add to the atrial arrhythmogenic phenotype by impaired left atrial emptying function, local conduction abnormalities, interstitial atrial fibrosis formation, and increased propensity for atrial fibrillation. |
| first_indexed | 2024-12-14T07:07:59Z |
| format | Article |
| id | doaj.art-4446522c540a4851a8ec1c4b1bc7e140 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-14T07:07:59Z |
| publishDate | 2017-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-4446522c540a4851a8ec1c4b1bc7e1402022-12-21T23:12:04ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802017-09-016910.1161/JAHA.117.006717Concomitant Obesity and Metabolic Syndrome Add to the Atrial Arrhythmogenic Phenotype in Male Hypertensive RatsMathias Hohl0Dennis H. Lau1Andreas Müller2Adrian D. Elliott3Benedikt Linz4Rajiv Mahajan5Jeroen M. L. Hendriks6Michael Böhm7Ulrich Schotten8Prashanthan Sanders9Dominik Linz10Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, GermanyCentre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, Royal Adelaide Hospital, University of Adelaide, AustraliaKlinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum des Saarlandes, Homburg/Saar, GermanyCentre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, Royal Adelaide Hospital, University of Adelaide, AustraliaKlinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, GermanyCentre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, Royal Adelaide Hospital, University of Adelaide, AustraliaCentre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, Royal Adelaide Hospital, University of Adelaide, AustraliaKlinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, GermanyCardiovascular Research Institute Maastricht (CARIM), University Maastricht, Maastricht, The NetherlandsCentre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, Royal Adelaide Hospital, University of Adelaide, AustraliaKlinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, GermanyBackgroundBesides hypertension, obesity and the metabolic syndrome have recently emerged as risk factors for atrial fibrillation. This study sought to delineate the development of an arrhythmogenic substrate for atrial fibrillation in hypertension with and without concomitant obesity and metabolic syndrome. Methods and ResultsWe compared obese spontaneously hypertensive rats (SHR‐obese, n=7–10) with lean hypertensive controls (SHR‐lean, n=7–10) and normotensive rats (n=7–10). Left atrial emptying function (MRI) and electrophysiological parameters were characterized before the hearts were harvested for histological and biochemical analyses. At the age of 38 weeks, SHR‐obese, but not SHR‐lean, showed increased body weight and impaired glucose tolerance together with dyslipidemia compared with normotensive rats. Mean blood pressure was similarly increased in SHR‐lean and SHR‐obese when compared with normotensive rats (178±9 and 180±8 mm Hg [not significant] versus 118±5 mm Hg, P<0.01 for both), but left ventricular end‐diastolic pressure was more increased in SHR‐obese than in SHR‐lean. Impairment of left atrial emptying function, increase in total atrial activation time, and conduction heterogeneity, as well as prolongation of inducible atrial fibrillation durations, were more pronounced in SHR‐obese as compared with SHR‐lean. Histological and biochemical examinations revealed enhanced triglycerides and more pronounced fibrosis in the left atrium of SHR‐obese. Besides increased expression of profibrotic markers in SHR‐lean and SHR‐obese, the profibrotic extracellular matrix protein osteopontin was highly upregulated only in SHR‐obese. ConclusionsIn addition to hypertension alone, concomitant obesity and metabolic syndrome add to the atrial arrhythmogenic phenotype by impaired left atrial emptying function, local conduction abnormalities, interstitial atrial fibrosis formation, and increased propensity for atrial fibrillation.https://www.ahajournals.org/doi/10.1161/JAHA.117.006717atrial fibrillationhypertensionmetabolic syndromeobesity |
| spellingShingle | Mathias Hohl Dennis H. Lau Andreas Müller Adrian D. Elliott Benedikt Linz Rajiv Mahajan Jeroen M. L. Hendriks Michael Böhm Ulrich Schotten Prashanthan Sanders Dominik Linz Concomitant Obesity and Metabolic Syndrome Add to the Atrial Arrhythmogenic Phenotype in Male Hypertensive Rats Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease atrial fibrillation hypertension metabolic syndrome obesity |
| title | Concomitant Obesity and Metabolic Syndrome Add to the Atrial Arrhythmogenic Phenotype in Male Hypertensive Rats |
| title_full | Concomitant Obesity and Metabolic Syndrome Add to the Atrial Arrhythmogenic Phenotype in Male Hypertensive Rats |
| title_fullStr | Concomitant Obesity and Metabolic Syndrome Add to the Atrial Arrhythmogenic Phenotype in Male Hypertensive Rats |
| title_full_unstemmed | Concomitant Obesity and Metabolic Syndrome Add to the Atrial Arrhythmogenic Phenotype in Male Hypertensive Rats |
| title_short | Concomitant Obesity and Metabolic Syndrome Add to the Atrial Arrhythmogenic Phenotype in Male Hypertensive Rats |
| title_sort | concomitant obesity and metabolic syndrome add to the atrial arrhythmogenic phenotype in male hypertensive rats |
| topic | atrial fibrillation hypertension metabolic syndrome obesity |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.117.006717 |
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