Paroxetine—Overview of the Molecular Mechanisms of Action
In the 21st century and especially during a pandemic, the diagnosis and treatment of depression is an essential part of the daily practice of many family doctors. It mainly affects patients in the age category 15–44 years, regardless of gender. Anxiety disorders are often diagnosed in children and a...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-02-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/4/1662 |
| _version_ | 1797413381137760256 |
|---|---|
| author | Magdalena Kowalska Jacek Nowaczyk Łukasz Fijałkowski Alicja Nowaczyk |
| author_facet | Magdalena Kowalska Jacek Nowaczyk Łukasz Fijałkowski Alicja Nowaczyk |
| author_sort | Magdalena Kowalska |
| collection | DOAJ |
| description | In the 21st century and especially during a pandemic, the diagnosis and treatment of depression is an essential part of the daily practice of many family doctors. It mainly affects patients in the age category 15–44 years, regardless of gender. Anxiety disorders are often diagnosed in children and adolescents. Social phobias can account for up to 13% of these diagnoses. Social anxiety manifests itself in fear of negative social assessment and humiliation, which disrupts the quality of social functioning. Treatment of the above-mentioned disorders is based on psychotherapy and pharmacotherapy. Serious side effects or mortality from antidepressant drug overdose are currently rare. Recent studies indicate that paroxetine (ATC code: N06AB), belonging to the selective serotonin reuptake inhibitors, has promising therapeutic effects and is used off-label in children and adolescents. The purpose of this review is to describe the interaction of paroxetine with several molecular targets in various points of view including the basic chemical and pharmaceutical properties. The central point of the review is focused on the pharmacodynamic analysis based on the molecular mechanism of binding paroxetine to various therapeutic targets. |
| first_indexed | 2024-03-09T05:16:53Z |
| format | Article |
| id | doaj.art-4448f95ac7ab4cce87c530b6a4c66243 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T05:16:53Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4448f95ac7ab4cce87c530b6a4c662432023-12-03T12:44:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01224166210.3390/ijms22041662Paroxetine—Overview of the Molecular Mechanisms of ActionMagdalena Kowalska0Jacek Nowaczyk1Łukasz Fijałkowski2Alicja Nowaczyk3Department of Organic Chemistry, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 2 dr. A. Jurasza St., 85-094 Bydgoszcz, PolandFaculty of Chemistry, Nicolaus Copernicus University in Toruń, 7 Gagarina Str., 87-100 Torun, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 2 dr. A. Jurasza St., 85-094 Bydgoszcz, PolandDepartment of Organic Chemistry, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 2 dr. A. Jurasza St., 85-094 Bydgoszcz, PolandIn the 21st century and especially during a pandemic, the diagnosis and treatment of depression is an essential part of the daily practice of many family doctors. It mainly affects patients in the age category 15–44 years, regardless of gender. Anxiety disorders are often diagnosed in children and adolescents. Social phobias can account for up to 13% of these diagnoses. Social anxiety manifests itself in fear of negative social assessment and humiliation, which disrupts the quality of social functioning. Treatment of the above-mentioned disorders is based on psychotherapy and pharmacotherapy. Serious side effects or mortality from antidepressant drug overdose are currently rare. Recent studies indicate that paroxetine (ATC code: N06AB), belonging to the selective serotonin reuptake inhibitors, has promising therapeutic effects and is used off-label in children and adolescents. The purpose of this review is to describe the interaction of paroxetine with several molecular targets in various points of view including the basic chemical and pharmaceutical properties. The central point of the review is focused on the pharmacodynamic analysis based on the molecular mechanism of binding paroxetine to various therapeutic targets.https://www.mdpi.com/1422-0067/22/4/1662paroxetineCYPMATGRK2EBOV |
| spellingShingle | Magdalena Kowalska Jacek Nowaczyk Łukasz Fijałkowski Alicja Nowaczyk Paroxetine—Overview of the Molecular Mechanisms of Action International Journal of Molecular Sciences paroxetine CYP MAT GRK2 EBOV |
| title | Paroxetine—Overview of the Molecular Mechanisms of Action |
| title_full | Paroxetine—Overview of the Molecular Mechanisms of Action |
| title_fullStr | Paroxetine—Overview of the Molecular Mechanisms of Action |
| title_full_unstemmed | Paroxetine—Overview of the Molecular Mechanisms of Action |
| title_short | Paroxetine—Overview of the Molecular Mechanisms of Action |
| title_sort | paroxetine overview of the molecular mechanisms of action |
| topic | paroxetine CYP MAT GRK2 EBOV |
| url | https://www.mdpi.com/1422-0067/22/4/1662 |
| work_keys_str_mv | AT magdalenakowalska paroxetineoverviewofthemolecularmechanismsofaction AT jaceknowaczyk paroxetineoverviewofthemolecularmechanismsofaction AT łukaszfijałkowski paroxetineoverviewofthemolecularmechanismsofaction AT alicjanowaczyk paroxetineoverviewofthemolecularmechanismsofaction |