Identifying common transcriptome signatures of cancer by interpreting deep learning models

Abstract Background Cancer is a set of diseases characterized by unchecked cell proliferation and invasion of surrounding tissues. The many genes that have been genetically associated with cancer or shown to directly contribute to oncogenesis vary widely between tumor types, but common gene signatur...

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Bibliographic Details
Main Authors: Anupama Jha, Mathieu Quesnel-Vallières, David Wang, Andrei Thomas-Tikhonenko, Kristen W Lynch, Yoseph Barash
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Genome Biology
Subjects:
Online Access:https://doi.org/10.1186/s13059-022-02681-3