A mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiation by X-ray and chemotherapy by Oxaliplatin
Interleukin-34 (IL-34) has been known as a factor that is involved with tumor progression and therapeutic resistance. However, there are limitations to addressing the mechanism of how IL-34 induces therapeutic resistance. Here, we show a mechanism of IL-34-induced resistance against cytotoxic anti-c...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2023.2238499 |
| _version_ | 1826914921493823488 |
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| author | Nanumi Han Haruka Wada Takuto Kobayashi Ryo Otsuka Ken-Ichiro Seino |
| author_facet | Nanumi Han Haruka Wada Takuto Kobayashi Ryo Otsuka Ken-Ichiro Seino |
| author_sort | Nanumi Han |
| collection | DOAJ |
| description | Interleukin-34 (IL-34) has been known as a factor that is involved with tumor progression and therapeutic resistance. However, there are limitations to addressing the mechanism of how IL-34 induces therapeutic resistance. Here, we show a mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiotherapy using X-ray and chemotherapy by Oxaliplatin. This research demonstrates that IL-34 immunologically changes the tumor microenvironment after treatments with radiation or chemotherapeutic agents such as oxaliplatin. We identified the changes in immune cells using flow cytometry and immunofluorescent (IF) staining, which are up-regulated upon the existence of IL-34. Overall, these findings demonstrate the possibility of IL-34 blockade as a novel combination therapy for cancer. |
| first_indexed | 2024-03-08T17:12:42Z |
| format | Article |
| id | doaj.art-444988661bf44caf8e8c6521c59364dd |
| institution | Directory Open Access Journal |
| issn | 2162-402X |
| language | English |
| last_indexed | 2025-02-17T11:52:08Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj.art-444988661bf44caf8e8c6521c59364dd2024-12-27T17:34:38ZengTaylor & Francis GroupOncoImmunology2162-402X2023-12-0112110.1080/2162402X.2023.2238499A mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiation by X-ray and chemotherapy by OxaliplatinNanumi Han0Haruka Wada1Takuto Kobayashi2Ryo Otsuka3Ken-Ichiro Seino4Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, JapanDivision of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, JapanDivision of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, JapanDivision of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, JapanDivision of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, JapanInterleukin-34 (IL-34) has been known as a factor that is involved with tumor progression and therapeutic resistance. However, there are limitations to addressing the mechanism of how IL-34 induces therapeutic resistance. Here, we show a mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiotherapy using X-ray and chemotherapy by Oxaliplatin. This research demonstrates that IL-34 immunologically changes the tumor microenvironment after treatments with radiation or chemotherapeutic agents such as oxaliplatin. We identified the changes in immune cells using flow cytometry and immunofluorescent (IF) staining, which are up-regulated upon the existence of IL-34. Overall, these findings demonstrate the possibility of IL-34 blockade as a novel combination therapy for cancer.https://www.tandfonline.com/doi/10.1080/2162402X.2023.2238499ChemotherapyIL-34immunosuppressionradiotherapytherapeutic resistance |
| spellingShingle | Nanumi Han Haruka Wada Takuto Kobayashi Ryo Otsuka Ken-Ichiro Seino A mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiation by X-ray and chemotherapy by Oxaliplatin OncoImmunology Chemotherapy IL-34 immunosuppression radiotherapy therapeutic resistance |
| title | A mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiation by X-ray and chemotherapy by Oxaliplatin |
| title_full | A mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiation by X-ray and chemotherapy by Oxaliplatin |
| title_fullStr | A mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiation by X-ray and chemotherapy by Oxaliplatin |
| title_full_unstemmed | A mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiation by X-ray and chemotherapy by Oxaliplatin |
| title_short | A mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiation by X-ray and chemotherapy by Oxaliplatin |
| title_sort | mechanism of il 34 induced resistance against cytotoxic anti cancer therapies such as radiation by x ray and chemotherapy by oxaliplatin |
| topic | Chemotherapy IL-34 immunosuppression radiotherapy therapeutic resistance |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2023.2238499 |
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