Multivalency regulates activity in an intrinsically disordered transcription factor

Multivalency regulates activity in an intrinsically disordered transcription factor

Show other versions (1)

The transcription factor ASCIZ (ATMIN, ZNF822) has an unusually high number of recognition motifs for the product of its main target gene, the hub protein LC8 (DYNLL1). Using a combination of biophysical methods, structural analysis by NMR and electron microscopy, and cellular transcription assays,...

Full description

Bibliographic Details
Main Authors: Sarah Clark, Janette B Myers, Ashleigh King, Radovan Fiala, Jiri Novacek, Grant Pearce, Jörg Heierhorst, Steve L Reichow, Elisar J Barbar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
transcription factors
Intrinsically disordered proteins
electron microscopy
multivalency
dynamic complexes
NMR
Online Access:https://elifesciences.org/articles/36258

Similar Items

Similar Items