Effect of Methotrexate and Omega 3 in Some Parameters Related With WBCs and RBCs in Male Rats
The current study included understanding the effect of methotrexate and omega-3 in the thyroid and parathyroid gland and some of the physiological and histological and genetic variables in some of the organs of the body in the male rats. The study included 56 animals were divided into three groups,...
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| Format: | Article |
| Language: | English |
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University of Anbar
2015-12-01
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| Series: | مجلة جامعة الانبار للعلوم الصرفة |
| Subjects: | |
| Online Access: | https://juaps.uoanbar.edu.iq/article_127543_545b500107cc089371538cec9ed33323.pdf |
| _version_ | 1797373264198107136 |
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| author | Muthana M. Awad Inaam N. Ali Alaa Sh. Mahmood |
| author_facet | Muthana M. Awad Inaam N. Ali Alaa Sh. Mahmood |
| author_sort | Muthana M. Awad |
| collection | DOAJ |
| description | The current study included understanding the effect of methotrexate and omega-3 in the thyroid and parathyroid gland and some of the physiological and histological and genetic variables in some of the organs of the body in the male rats. The study included 56 animals were divided into three groups, the first and second groups were divided into three secondary groups, the first secondary group was given the drug methotrexate only in concentration 0.05 , 0.125 and 0.250 mg / kg for 8 weeks while the secondary second group was given drug methotrexate in the same concentrations of the first group, as well as give it omega-3 concentration of 300 mg / kg for 8 weeks, the third group was considered as control group. After finishing of dosage, the animals killed and took blood samples and organs to do the required tests, included measuring of blood parameters, such as RBC ,PCV ,Hb ,MCV, MCH and MCHC. In addition to measure the number of white blood cell count WBC and Differential white blood cells, where the results showed the presence of a rise in both the RBC, PCV, Hb in the low and medium concentration of methotrexate while decreased in high concentration, omega-3 work to reduce the variables above in the low and medium concentration while worked on reducing it in the high concentration, moreover a variable of MCV and MCH and MCHC has not changed morally. With respect to the WBC was low in the totals for the study when giving methotrexate while rose when giving omega-3 with this druge, also neutrophil cells was low and accompanied by a rise in a monoytes in all concentrations of Methotrexate were not for omega 3 noticeable effect on these cells decreased. The results showed a decline in the lymph and acidophilus cells in the low concentration while rose in the medium and high concentration of Methotrexate. Omega-3 worked on the rise it in concentrations above, with respect to basophiles cells increased in the low and high concentration and decreased in medium and the omega-3 was not effect of them. |
| first_indexed | 2024-03-08T18:46:49Z |
| format | Article |
| id | doaj.art-444b0ab9c95348e8aad204aa01c06786 |
| institution | Directory Open Access Journal |
| issn | 1991-8941 2706-6703 |
| language | English |
| last_indexed | 2024-03-08T18:46:49Z |
| publishDate | 2015-12-01 |
| publisher | University of Anbar |
| record_format | Article |
| series | مجلة جامعة الانبار للعلوم الصرفة |
| spelling | doaj.art-444b0ab9c95348e8aad204aa01c067862023-12-28T21:58:12ZengUniversity of Anbarمجلة جامعة الانبار للعلوم الصرفة1991-89412706-67032015-12-01931510.37652/juaps.2015.127543127543Effect of Methotrexate and Omega 3 in Some Parameters Related With WBCs and RBCs in Male RatsMuthana M. Awad0Inaam N. Ali1Alaa Sh. Mahmood2University of Anbar -College of SciencesMinistry of Sciences and Technology- Water and Environment DirectoryUniversity of Anbar - College of ScienceThe current study included understanding the effect of methotrexate and omega-3 in the thyroid and parathyroid gland and some of the physiological and histological and genetic variables in some of the organs of the body in the male rats. The study included 56 animals were divided into three groups, the first and second groups were divided into three secondary groups, the first secondary group was given the drug methotrexate only in concentration 0.05 , 0.125 and 0.250 mg / kg for 8 weeks while the secondary second group was given drug methotrexate in the same concentrations of the first group, as well as give it omega-3 concentration of 300 mg / kg for 8 weeks, the third group was considered as control group. After finishing of dosage, the animals killed and took blood samples and organs to do the required tests, included measuring of blood parameters, such as RBC ,PCV ,Hb ,MCV, MCH and MCHC. In addition to measure the number of white blood cell count WBC and Differential white blood cells, where the results showed the presence of a rise in both the RBC, PCV, Hb in the low and medium concentration of methotrexate while decreased in high concentration, omega-3 work to reduce the variables above in the low and medium concentration while worked on reducing it in the high concentration, moreover a variable of MCV and MCH and MCHC has not changed morally. With respect to the WBC was low in the totals for the study when giving methotrexate while rose when giving omega-3 with this druge, also neutrophil cells was low and accompanied by a rise in a monoytes in all concentrations of Methotrexate were not for omega 3 noticeable effect on these cells decreased. The results showed a decline in the lymph and acidophilus cells in the low concentration while rose in the medium and high concentration of Methotrexate. Omega-3 worked on the rise it in concentrations above, with respect to basophiles cells increased in the low and high concentration and decreased in medium and the omega-3 was not effect of them.https://juaps.uoanbar.edu.iq/article_127543_545b500107cc089371538cec9ed33323.pdfmethotrexateomegarbcswbcs |
| spellingShingle | Muthana M. Awad Inaam N. Ali Alaa Sh. Mahmood Effect of Methotrexate and Omega 3 in Some Parameters Related With WBCs and RBCs in Male Rats مجلة جامعة الانبار للعلوم الصرفة methotrexate omega rbcs wbcs |
| title | Effect of Methotrexate and Omega 3 in Some Parameters Related With WBCs and RBCs in Male Rats |
| title_full | Effect of Methotrexate and Omega 3 in Some Parameters Related With WBCs and RBCs in Male Rats |
| title_fullStr | Effect of Methotrexate and Omega 3 in Some Parameters Related With WBCs and RBCs in Male Rats |
| title_full_unstemmed | Effect of Methotrexate and Omega 3 in Some Parameters Related With WBCs and RBCs in Male Rats |
| title_short | Effect of Methotrexate and Omega 3 in Some Parameters Related With WBCs and RBCs in Male Rats |
| title_sort | effect of methotrexate and omega 3 in some parameters related with wbcs and rbcs in male rats |
| topic | methotrexate omega rbcs wbcs |
| url | https://juaps.uoanbar.edu.iq/article_127543_545b500107cc089371538cec9ed33323.pdf |
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