The combination of Puerariae Lobatae Radix and Chuanxiong Rhizoma enhanced the absorption and pharmacokinetics of puerarin by modulating the intestinal barrier and influenced gut microbiota

The combination of Puerariae Lobatae Radix and Chuanxiong Rhizoma enhanced the absorption and pharmacokinetics of puerarin by modulating the intestinal barrier and influenced gut microbiota

Puerarin, the most important flavonoid in Puerariae Lobatae Radix (PLR), has high biological activity but poor oral absorption. This study investigated how to enhance the absorption and pharmacokinetics of puerarin through modulating the intestinal barrier. Analyses of intestinal absorption, pharmac...

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Bibliographic Details
Main Authors: Runzhi Chen, Peng Wu, Zheng Cai, Lan Tang, Ling Ye, Chuqi Hou, Na Yang, Jie Zhao
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Journal of Functional Foods
Subjects:
Puerarin
Ligustrazine
Absorption
Pharmacokinetics
Intestinal barrier
Gut microbiota
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464618302603

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