Invasive candidiasis and candidemia in pediatric and neonatal patients: A review of current guidelines
Several international and national guidelines have been proposed for the treatment and prevention of invasive candidiasis/candidemia (IC/C) in both neonatal and pediatric patients. This article is a review of the current guidelines, recommendations, and expert panel consensus of a number of associat...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2018-09-01
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| Series: | Current Medical Mycology |
| Subjects: | |
| Online Access: | http://cmm.mazums.ac.ir/browse.php?a_code=A-10-276-1&slc_lang=en&sid=1 |
| _version_ | 1818420923744649216 |
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| author | Eleni Vasileiou Athanasia Apsemidou Timoleon-Achilleas Vyzantiadis Athanasios Tragiannidis |
| author_facet | Eleni Vasileiou Athanasia Apsemidou Timoleon-Achilleas Vyzantiadis Athanasios Tragiannidis |
| author_sort | Eleni Vasileiou |
| collection | DOAJ |
| description | Several international and national guidelines have been proposed for the treatment and prevention of invasive candidiasis/candidemia (IC/C) in both neonatal and pediatric patients. This article is a review of the current guidelines, recommendations, and expert panel consensus of a number of associations and conferences on the prevention and management of IC and candidemia in both pediatric and neonatal patients. The investigated resources included the Infectious Diseases Society of America, the European Conference on Infection in Leukaemia, the European Society of Clinical Microbiology and Infectious Diseases, the German Speaking Mycological Society/Paul-Ehrlich Society for Chemotherapy, as well as the Canadian, Middle Eastern, and Australian guidelines. Echinocandins and liposomal amphotericin B (L-AmB) are the first-line agents in the treatment of IC and candidemia both for immunocompetent and immunocompromised pediatric patients. The recommendations suggested to keep patients under sterile conditions for at least 14 days after blood cultures as the prompt initiation of antifungal treatment. Guidelines addressing the neonates recommended to use L-AmB, deoxycholate AmB (D-AmB), and fluconazole based on three main principles of no previous exposure to azoles, the prompt initiation of antifungal treatment, and control of predisposing underlying conditions. Despite minor differences among the investigated guidelines, general treatment recommendations suggest the prompt initiation of antifungal treatment and control of all predisposing underlying conditions.
Keywords: Invasive candidiasis, Candidemia, Children, Guidelines, Neonates, Prevention,Treatment |
| first_indexed | 2024-12-14T13:02:11Z |
| format | Article |
| id | doaj.art-444d366ef59f41f488fb149abd8183b5 |
| institution | Directory Open Access Journal |
| issn | 2423-3439 2423-3420 |
| language | English |
| last_indexed | 2024-12-14T13:02:11Z |
| publishDate | 2018-09-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Current Medical Mycology |
| spelling | doaj.art-444d366ef59f41f488fb149abd8183b52022-12-21T23:00:25ZengMazandaran University of Medical SciencesCurrent Medical Mycology2423-34392423-34202018-09-01432833Invasive candidiasis and candidemia in pediatric and neonatal patients: A review of current guidelinesEleni Vasileiou0Athanasia Apsemidou1Timoleon-Achilleas Vyzantiadis2Athanasios Tragiannidis3 Hematology Oncology Unit, 2nd Pediatric Department of Aristotle University of Thessaloniki, AHEPA General Hospital, Thessaloniki, Greece 1st Department of Internal Medicine, Papanikolaou General Hospital, Thessaloniki, Greece Medical Biopathology Microbiology 1st Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Greece Hematology Oncology Unit, 2nd Pediatric Department of Aristotle University of Thessaloniki, AHEPA General Hospital, Thessaloniki, Greece Several international and national guidelines have been proposed for the treatment and prevention of invasive candidiasis/candidemia (IC/C) in both neonatal and pediatric patients. This article is a review of the current guidelines, recommendations, and expert panel consensus of a number of associations and conferences on the prevention and management of IC and candidemia in both pediatric and neonatal patients. The investigated resources included the Infectious Diseases Society of America, the European Conference on Infection in Leukaemia, the European Society of Clinical Microbiology and Infectious Diseases, the German Speaking Mycological Society/Paul-Ehrlich Society for Chemotherapy, as well as the Canadian, Middle Eastern, and Australian guidelines. Echinocandins and liposomal amphotericin B (L-AmB) are the first-line agents in the treatment of IC and candidemia both for immunocompetent and immunocompromised pediatric patients. The recommendations suggested to keep patients under sterile conditions for at least 14 days after blood cultures as the prompt initiation of antifungal treatment. Guidelines addressing the neonates recommended to use L-AmB, deoxycholate AmB (D-AmB), and fluconazole based on three main principles of no previous exposure to azoles, the prompt initiation of antifungal treatment, and control of predisposing underlying conditions. Despite minor differences among the investigated guidelines, general treatment recommendations suggest the prompt initiation of antifungal treatment and control of all predisposing underlying conditions. Keywords: Invasive candidiasis, Candidemia, Children, Guidelines, Neonates, Prevention,Treatmenthttp://cmm.mazums.ac.ir/browse.php?a_code=A-10-276-1&slc_lang=en&sid=1Invasive candidiasisCandidemiaChildrenGuidelinesNeonatesPreventionTreatment |
| spellingShingle | Eleni Vasileiou Athanasia Apsemidou Timoleon-Achilleas Vyzantiadis Athanasios Tragiannidis Invasive candidiasis and candidemia in pediatric and neonatal patients: A review of current guidelines Current Medical Mycology Invasive candidiasis Candidemia Children Guidelines Neonates Prevention Treatment |
| title | Invasive candidiasis and candidemia in pediatric and neonatal patients: A review of current guidelines |
| title_full | Invasive candidiasis and candidemia in pediatric and neonatal patients: A review of current guidelines |
| title_fullStr | Invasive candidiasis and candidemia in pediatric and neonatal patients: A review of current guidelines |
| title_full_unstemmed | Invasive candidiasis and candidemia in pediatric and neonatal patients: A review of current guidelines |
| title_short | Invasive candidiasis and candidemia in pediatric and neonatal patients: A review of current guidelines |
| title_sort | invasive candidiasis and candidemia in pediatric and neonatal patients a review of current guidelines |
| topic | Invasive candidiasis Candidemia Children Guidelines Neonates Prevention Treatment |
| url | http://cmm.mazums.ac.ir/browse.php?a_code=A-10-276-1&slc_lang=en&sid=1 |
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