ABCG2 Expression as a Potential Survival Predictor in Human Gliomas
Gliomas are notably challenging to treat due to their invasive nature and resistance to conventional therapies. The ABCG2 protein has attracted attention for its role in multidrug resistance, complicating treatment effectiveness. This study scrutinized the relationship between ABCG2 expression and g...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/6/3116 |
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| author | Marina Raguž Marko Tarle Danko Müller Čedna Tomasović-Lončarić Hana Chudy Tonko Marinović Darko Chudy |
| author_facet | Marina Raguž Marko Tarle Danko Müller Čedna Tomasović-Lončarić Hana Chudy Tonko Marinović Darko Chudy |
| author_sort | Marina Raguž |
| collection | DOAJ |
| description | Gliomas are notably challenging to treat due to their invasive nature and resistance to conventional therapies. The ABCG2 protein has attracted attention for its role in multidrug resistance, complicating treatment effectiveness. This study scrutinized the relationship between ABCG2 expression and glioma grade and the role of ABCG2 in the process of glioma progression, aiming to evaluate ABCG2 expression as a predictive factor of tumor progression and patient survival. Conducted at Dubrava University Hospital, Zagreb, Croatia, the study analyzed 152 glioma specimens from 2013 to 2022, assessing ABCG2 expression alongside standard clinical markers. A significant association was found between patients’ survival and the ABCG2 profile (<i>p</i> = 0.003, <i>r</i> = 0.24), separately for patients who underwent chemotherapy (<i>p</i> = 0.0004, <i>r</i> = 0.32) and radiotherapy (<i>p</i> = 0.003, <i>r</i> = 0.29). Furthermore, the ABCG2 profile was significantly associated with disease progression (<i>p</i> = 0.007, <i>r</i> = 0.23), tumor grade (<i>p</i> = 0.0002, <i>r</i> = 0.31), and Ki67 expression (<i>p</i> = 0.0004, <i>r</i> = 0.31). ABCG2-positive tumor cells only showed association with Ki67 expression (<i>p</i> = 0.002, <i>r</i> = 0.28). The ABCG2 profile was found to affect the overall patient survival (<i>p</i> = 0.02) and represent a moderate indicator of tumor progression (<i>p</i> = 0.01), unlike the percentage of ABCG2-positive tumor cells. ABCG2 may serve as a marker of angiogenesis and vascular abnormalities within tumors, predicting glioma progression and treatment response. Targeting ABCG2 could enhance chemoradiotherapy efficacy and improve patient outcomes, which highlights its value in assessing tumor aggressiveness and designing treatment strategies. |
| first_indexed | 2024-04-24T18:12:15Z |
| format | Article |
| id | doaj.art-444dbc1b09f749718e76511dd44304cd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T18:12:15Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-444dbc1b09f749718e76511dd44304cd2024-03-27T13:45:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01256311610.3390/ijms25063116ABCG2 Expression as a Potential Survival Predictor in Human GliomasMarina Raguž0Marko Tarle1Danko Müller2Čedna Tomasović-Lončarić3Hana Chudy4Tonko Marinović5Darko Chudy6Department of Neurosurgery, Dubrava University Hospital, 10000 Zagreb, CroatiaDepartment of Maxillofacial Surgery, Dubrava University Hospital, 10000 Zagreb, CroatiaDepartment of Pathology and Cytology, Dubrava University Hospital, 10000 Zagreb, CroatiaSchool of Medicine, Catholic University of Croatia, 10000 Zagreb, CroatiaDepartment of Neurology, Dubrava University Hospital, 10000 Zagreb, CroatiaDepartment of Neurosurgery, Dubrava University Hospital, 10000 Zagreb, CroatiaDepartment of Neurosurgery, Dubrava University Hospital, 10000 Zagreb, CroatiaGliomas are notably challenging to treat due to their invasive nature and resistance to conventional therapies. The ABCG2 protein has attracted attention for its role in multidrug resistance, complicating treatment effectiveness. This study scrutinized the relationship between ABCG2 expression and glioma grade and the role of ABCG2 in the process of glioma progression, aiming to evaluate ABCG2 expression as a predictive factor of tumor progression and patient survival. Conducted at Dubrava University Hospital, Zagreb, Croatia, the study analyzed 152 glioma specimens from 2013 to 2022, assessing ABCG2 expression alongside standard clinical markers. A significant association was found between patients’ survival and the ABCG2 profile (<i>p</i> = 0.003, <i>r</i> = 0.24), separately for patients who underwent chemotherapy (<i>p</i> = 0.0004, <i>r</i> = 0.32) and radiotherapy (<i>p</i> = 0.003, <i>r</i> = 0.29). Furthermore, the ABCG2 profile was significantly associated with disease progression (<i>p</i> = 0.007, <i>r</i> = 0.23), tumor grade (<i>p</i> = 0.0002, <i>r</i> = 0.31), and Ki67 expression (<i>p</i> = 0.0004, <i>r</i> = 0.31). ABCG2-positive tumor cells only showed association with Ki67 expression (<i>p</i> = 0.002, <i>r</i> = 0.28). The ABCG2 profile was found to affect the overall patient survival (<i>p</i> = 0.02) and represent a moderate indicator of tumor progression (<i>p</i> = 0.01), unlike the percentage of ABCG2-positive tumor cells. ABCG2 may serve as a marker of angiogenesis and vascular abnormalities within tumors, predicting glioma progression and treatment response. Targeting ABCG2 could enhance chemoradiotherapy efficacy and improve patient outcomes, which highlights its value in assessing tumor aggressiveness and designing treatment strategies.https://www.mdpi.com/1422-0067/25/6/3116gliomaABCG2CNStumor progression |
| spellingShingle | Marina Raguž Marko Tarle Danko Müller Čedna Tomasović-Lončarić Hana Chudy Tonko Marinović Darko Chudy ABCG2 Expression as a Potential Survival Predictor in Human Gliomas International Journal of Molecular Sciences glioma ABCG2 CNS tumor progression |
| title | ABCG2 Expression as a Potential Survival Predictor in Human Gliomas |
| title_full | ABCG2 Expression as a Potential Survival Predictor in Human Gliomas |
| title_fullStr | ABCG2 Expression as a Potential Survival Predictor in Human Gliomas |
| title_full_unstemmed | ABCG2 Expression as a Potential Survival Predictor in Human Gliomas |
| title_short | ABCG2 Expression as a Potential Survival Predictor in Human Gliomas |
| title_sort | abcg2 expression as a potential survival predictor in human gliomas |
| topic | glioma ABCG2 CNS tumor progression |
| url | https://www.mdpi.com/1422-0067/25/6/3116 |
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