Human Papillomavirus Infections and Increased Risk of Incident Osteoporosis: A Nationwide Population-Based Cohort Study
Patients with viral infections are susceptible to osteoporosis. This cohort study investigated the correlation between human papillomavirus (HPV) infections and the risk of osteoporosis via 12,936 patients with new-onset HPV infections and propensity score-matched non-HPV controls enrolled in Taiwan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/4/1021 |
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| author | Kevin Sheng-Kai Ma Ning-Chien Chin Ting-Yu Tu Yao-Cheng Wu Hei-Tung Yip James Cheng-Chung Wei Ren-in Chang |
| author_facet | Kevin Sheng-Kai Ma Ning-Chien Chin Ting-Yu Tu Yao-Cheng Wu Hei-Tung Yip James Cheng-Chung Wei Ren-in Chang |
| author_sort | Kevin Sheng-Kai Ma |
| collection | DOAJ |
| description | Patients with viral infections are susceptible to osteoporosis. This cohort study investigated the correlation between human papillomavirus (HPV) infections and the risk of osteoporosis via 12,936 patients with new-onset HPV infections and propensity score-matched non-HPV controls enrolled in Taiwan. The primary endpoint was incident osteoporosis following HPV infections. Cox proportional hazards regression analysis and the Kaplan-Meier method was used to determine the effect of HPV infections on the risk of osteoporosis. Patients with HPV infections presented with a significantly high risk of osteoporosis (adjusted hazard ratio, aHR = 1.32, 95% CI = 1.06–1.65) after adjusting for sex, age, comorbidities and co-medications. Subgroup analysis provided that populations at risk of HPV-associated osteoporosis were females (aHR = 1.33; 95% CI = 1.04–1.71), those aged between 60 and 80 years (aHR = 1.45, 95% CI = 1.01–2.08 for patients aged 60–70; aHR = 1.51; 95% CI = 1.07–2.12 for patients aged 70–80), and patients with long-term use of glucocorticoids (aHR = 2.17; 95% CI = 1.11–4.22). HPV-infected patients who did not receive treatments for HPV infections were at a greater risk (aHR = 1.40; 95% CI = 1.09–1.80) of osteoporosis, while the risk of osteoporosis in those who received treatments for HPV infections did not reach statistical significance (aHR = 1.14; 95% CI = 0.78–1.66). Patients with HPV infections presented with a high risk of subsequent osteoporosis. Treatments for HPV infections attenuated the risk of HPV-associated osteoporosis. |
| first_indexed | 2024-03-11T04:26:00Z |
| format | Article |
| id | doaj.art-444eff91a677405f939d5a124011f920 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T04:26:00Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-444eff91a677405f939d5a124011f9202023-11-17T21:47:05ZengMDPI AGViruses1999-49152023-04-01154102110.3390/v15041021Human Papillomavirus Infections and Increased Risk of Incident Osteoporosis: A Nationwide Population-Based Cohort StudyKevin Sheng-Kai Ma0Ning-Chien Chin1Ting-Yu Tu2Yao-Cheng Wu3Hei-Tung Yip4James Cheng-Chung Wei5Ren-in Chang6Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USADepartment of Orthopedics, Taichung Veterans General Hospital, Taichung 407, TaiwanDepartment of Orthopedics, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung 402, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung 404, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanDepartment of Recreation Sports Management, Tajen University, Pingtung 907, TaiwanPatients with viral infections are susceptible to osteoporosis. This cohort study investigated the correlation between human papillomavirus (HPV) infections and the risk of osteoporosis via 12,936 patients with new-onset HPV infections and propensity score-matched non-HPV controls enrolled in Taiwan. The primary endpoint was incident osteoporosis following HPV infections. Cox proportional hazards regression analysis and the Kaplan-Meier method was used to determine the effect of HPV infections on the risk of osteoporosis. Patients with HPV infections presented with a significantly high risk of osteoporosis (adjusted hazard ratio, aHR = 1.32, 95% CI = 1.06–1.65) after adjusting for sex, age, comorbidities and co-medications. Subgroup analysis provided that populations at risk of HPV-associated osteoporosis were females (aHR = 1.33; 95% CI = 1.04–1.71), those aged between 60 and 80 years (aHR = 1.45, 95% CI = 1.01–2.08 for patients aged 60–70; aHR = 1.51; 95% CI = 1.07–2.12 for patients aged 70–80), and patients with long-term use of glucocorticoids (aHR = 2.17; 95% CI = 1.11–4.22). HPV-infected patients who did not receive treatments for HPV infections were at a greater risk (aHR = 1.40; 95% CI = 1.09–1.80) of osteoporosis, while the risk of osteoporosis in those who received treatments for HPV infections did not reach statistical significance (aHR = 1.14; 95% CI = 0.78–1.66). Patients with HPV infections presented with a high risk of subsequent osteoporosis. Treatments for HPV infections attenuated the risk of HPV-associated osteoporosis.https://www.mdpi.com/1999-4915/15/4/1021human papillomavirusosteoporosiscohort studyviral infections |
| spellingShingle | Kevin Sheng-Kai Ma Ning-Chien Chin Ting-Yu Tu Yao-Cheng Wu Hei-Tung Yip James Cheng-Chung Wei Ren-in Chang Human Papillomavirus Infections and Increased Risk of Incident Osteoporosis: A Nationwide Population-Based Cohort Study Viruses human papillomavirus osteoporosis cohort study viral infections |
| title | Human Papillomavirus Infections and Increased Risk of Incident Osteoporosis: A Nationwide Population-Based Cohort Study |
| title_full | Human Papillomavirus Infections and Increased Risk of Incident Osteoporosis: A Nationwide Population-Based Cohort Study |
| title_fullStr | Human Papillomavirus Infections and Increased Risk of Incident Osteoporosis: A Nationwide Population-Based Cohort Study |
| title_full_unstemmed | Human Papillomavirus Infections and Increased Risk of Incident Osteoporosis: A Nationwide Population-Based Cohort Study |
| title_short | Human Papillomavirus Infections and Increased Risk of Incident Osteoporosis: A Nationwide Population-Based Cohort Study |
| title_sort | human papillomavirus infections and increased risk of incident osteoporosis a nationwide population based cohort study |
| topic | human papillomavirus osteoporosis cohort study viral infections |
| url | https://www.mdpi.com/1999-4915/15/4/1021 |
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