Vascular network-inspired fluidic system (VasFluidics) with spatially functionalizable membranous walls
Abstract In vascular networks, the transport across different vessel walls regulates chemical compositions in blood over space and time. Replicating such trans-wall transport with spatial heterogeneity can empower synthetic fluidic systems to program fluid compositions spatiotemporally. However, it...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-45781-3 |
| _version_ | 1797274087257538560 |
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| author | Yafeng Yu Yi Pan Yanting Shen Jingxuan Tian Ruotong Zhang Wei Guo Chang Li Ho Cheung Shum |
| author_facet | Yafeng Yu Yi Pan Yanting Shen Jingxuan Tian Ruotong Zhang Wei Guo Chang Li Ho Cheung Shum |
| author_sort | Yafeng Yu |
| collection | DOAJ |
| description | Abstract In vascular networks, the transport across different vessel walls regulates chemical compositions in blood over space and time. Replicating such trans-wall transport with spatial heterogeneity can empower synthetic fluidic systems to program fluid compositions spatiotemporally. However, it remains challenging as existing synthetic channel walls are typically impermeable or composed of homogeneous materials without functional heterogeneity. This work presents a vascular network-inspired fluidic system (VasFluidics), which is functionalizable for spatially different trans-wall transport. Facilitated by embedded three-dimensional (3D) printing, elastic, ultrathin, and semipermeable walls self-assemble electrostatically. Physicochemical reactions between fluids and walls are localized to vary the trans-wall molecules among separate regions, for instance, by confining solutions or locally immobilizing enzymes on the outside of channels. Therefore, fluid compositions can be regulated spatiotemporally, for example, to mimic blood changes during glucose absorption and metabolism. Our VasFluidics expands opportunities to replicate biofluid processing in nature, providing an alternative to traditional fluidics. |
| first_indexed | 2024-03-07T14:54:21Z |
| format | Article |
| id | doaj.art-444f26744ba947faa7dd251ffb054819 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-07T14:54:21Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-444f26744ba947faa7dd251ffb0548192024-03-05T19:31:47ZengNature PortfolioNature Communications2041-17232024-02-0115111210.1038/s41467-024-45781-3Vascular network-inspired fluidic system (VasFluidics) with spatially functionalizable membranous wallsYafeng Yu0Yi Pan1Yanting Shen2Jingxuan Tian3Ruotong Zhang4Wei Guo5Chang Li6Ho Cheung Shum7Department of Mechanical Engineering, The University of Hong KongDepartment of Mechanical Engineering, The University of Hong KongDepartment of Mechanical Engineering, The University of Hong KongDepartment of Mechanical Engineering, The University of Hong KongDepartment of Mechanical Engineering, The University of Hong KongDepartment of Mechanical Engineering, The University of Hong KongDepartment of Mechanical Engineering, The University of Hong KongDepartment of Mechanical Engineering, The University of Hong KongAbstract In vascular networks, the transport across different vessel walls regulates chemical compositions in blood over space and time. Replicating such trans-wall transport with spatial heterogeneity can empower synthetic fluidic systems to program fluid compositions spatiotemporally. However, it remains challenging as existing synthetic channel walls are typically impermeable or composed of homogeneous materials without functional heterogeneity. This work presents a vascular network-inspired fluidic system (VasFluidics), which is functionalizable for spatially different trans-wall transport. Facilitated by embedded three-dimensional (3D) printing, elastic, ultrathin, and semipermeable walls self-assemble electrostatically. Physicochemical reactions between fluids and walls are localized to vary the trans-wall molecules among separate regions, for instance, by confining solutions or locally immobilizing enzymes on the outside of channels. Therefore, fluid compositions can be regulated spatiotemporally, for example, to mimic blood changes during glucose absorption and metabolism. Our VasFluidics expands opportunities to replicate biofluid processing in nature, providing an alternative to traditional fluidics.https://doi.org/10.1038/s41467-024-45781-3 |
| spellingShingle | Yafeng Yu Yi Pan Yanting Shen Jingxuan Tian Ruotong Zhang Wei Guo Chang Li Ho Cheung Shum Vascular network-inspired fluidic system (VasFluidics) with spatially functionalizable membranous walls Nature Communications |
| title | Vascular network-inspired fluidic system (VasFluidics) with spatially functionalizable membranous walls |
| title_full | Vascular network-inspired fluidic system (VasFluidics) with spatially functionalizable membranous walls |
| title_fullStr | Vascular network-inspired fluidic system (VasFluidics) with spatially functionalizable membranous walls |
| title_full_unstemmed | Vascular network-inspired fluidic system (VasFluidics) with spatially functionalizable membranous walls |
| title_short | Vascular network-inspired fluidic system (VasFluidics) with spatially functionalizable membranous walls |
| title_sort | vascular network inspired fluidic system vasfluidics with spatially functionalizable membranous walls |
| url | https://doi.org/10.1038/s41467-024-45781-3 |
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