Diagnosis of Disseminated Toxoplasmosis by Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of a Patient with AIDS
Pulmonary toxoplasmosis is a challenging diagnosis in immunosuppressed patients with nonspecific clinical picture and radiologic findings. We present a case of pneumonia due to Toxoplasma gondii diagnosed by polymerase chain reaction (PCR) in the bronchoalveolar lavage (BAL) fluid of a patient with...
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| Format: | Article |
| Language: | English |
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Hospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS)
2009-08-01
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| Series: | Clinical and Biomedical Research |
| Subjects: | |
| Online Access: | https://seer.ufrgs.br/index.php/hcpa/article/view/6937 |
| _version_ | 1798038499137421312 |
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| author | Jose Miguel Dora Guilherme Geib Fernanda de-Paris Alice Beatriz Machado Tania Weber Furlanetto Carolina Fischinger Moura de Souza Rodrigo Pires dos Santos |
| author_facet | Jose Miguel Dora Guilherme Geib Fernanda de-Paris Alice Beatriz Machado Tania Weber Furlanetto Carolina Fischinger Moura de Souza Rodrigo Pires dos Santos |
| author_sort | Jose Miguel Dora |
| collection | DOAJ |
| description | Pulmonary toxoplasmosis is a challenging diagnosis in immunosuppressed patients with nonspecific clinical picture and radiologic findings. We present a case of pneumonia due to Toxoplasma gondii diagnosed by polymerase chain reaction (PCR) in the bronchoalveolar lavage (BAL) fluid of a patient with acquired immunodeficiency syndrome (AIDS). Coinfection with Pneumocystis jirovecii was found in the same specimen. Direct examination and culture for bacteria, mycobacteria and other fungus were negative. Despite the intensive management, respiratory compromise evolved rapidly, with the need for ventilatory support. Acute respiratory distress syndrome developed, and the patient died of multiple organ failure. This case illustrates that a high index of suspicion is necessary for diagnosis of pulmonary toxoplasmosis, a potentially fatal condition. Due to high diagnostic performance, PCR in BAL fluid should be included in the evaluation of immunosuppressed patients with nonspecific pulmonary diseases.
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| first_indexed | 2024-04-11T21:41:03Z |
| format | Article |
| id | doaj.art-444fdd0d9e3d45598180ead0c569996d |
| institution | Directory Open Access Journal |
| issn | 2357-9730 |
| language | English |
| last_indexed | 2024-04-11T21:41:03Z |
| publishDate | 2009-08-01 |
| publisher | Hospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS) |
| record_format | Article |
| series | Clinical and Biomedical Research |
| spelling | doaj.art-444fdd0d9e3d45598180ead0c569996d2022-12-22T04:01:35ZengHospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS)Clinical and Biomedical Research2357-97302009-08-012925596Diagnosis of Disseminated Toxoplasmosis by Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of a Patient with AIDSJose Miguel Dora0Guilherme Geib1Fernanda de-Paris2Alice Beatriz Machado3Tania Weber Furlanetto4Carolina Fischinger Moura de Souza5Rodrigo Pires dos Santos6Hospital de Clínicas de Porto Alegre, RSHospital de Clínicas de Porto Alegre, RSHospital de Clínicas de Porto AlegreHospital de Clínicas de Porto Alegre, RSHospital de Clínicas de Porto Alegre, RSHospital de Clínicas de Porto Alegre, RSHospital de Clínicas de Porto Alegre, RSPulmonary toxoplasmosis is a challenging diagnosis in immunosuppressed patients with nonspecific clinical picture and radiologic findings. We present a case of pneumonia due to Toxoplasma gondii diagnosed by polymerase chain reaction (PCR) in the bronchoalveolar lavage (BAL) fluid of a patient with acquired immunodeficiency syndrome (AIDS). Coinfection with Pneumocystis jirovecii was found in the same specimen. Direct examination and culture for bacteria, mycobacteria and other fungus were negative. Despite the intensive management, respiratory compromise evolved rapidly, with the need for ventilatory support. Acute respiratory distress syndrome developed, and the patient died of multiple organ failure. This case illustrates that a high index of suspicion is necessary for diagnosis of pulmonary toxoplasmosis, a potentially fatal condition. Due to high diagnostic performance, PCR in BAL fluid should be included in the evaluation of immunosuppressed patients with nonspecific pulmonary diseases. https://seer.ufrgs.br/index.php/hcpa/article/view/6937PCRHIVAIDStoxoplasmosisdisseminated toxoplasmosis |
| spellingShingle | Jose Miguel Dora Guilherme Geib Fernanda de-Paris Alice Beatriz Machado Tania Weber Furlanetto Carolina Fischinger Moura de Souza Rodrigo Pires dos Santos Diagnosis of Disseminated Toxoplasmosis by Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of a Patient with AIDS Clinical and Biomedical Research PCR HIV AIDS toxoplasmosis disseminated toxoplasmosis |
| title | Diagnosis of Disseminated Toxoplasmosis by Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of a Patient with AIDS |
| title_full | Diagnosis of Disseminated Toxoplasmosis by Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of a Patient with AIDS |
| title_fullStr | Diagnosis of Disseminated Toxoplasmosis by Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of a Patient with AIDS |
| title_full_unstemmed | Diagnosis of Disseminated Toxoplasmosis by Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of a Patient with AIDS |
| title_short | Diagnosis of Disseminated Toxoplasmosis by Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of a Patient with AIDS |
| title_sort | diagnosis of disseminated toxoplasmosis by polymerase chain reaction in bronchoalveolar lavage fluid of a patient with aids |
| topic | PCR HIV AIDS toxoplasmosis disseminated toxoplasmosis |
| url | https://seer.ufrgs.br/index.php/hcpa/article/view/6937 |
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