Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factors
Objective:The clinical feature of breast cancer is very heterogeneous because of the variable prognostic factors impact its behaviour. The aim of study is to find the prognostic importance of Ki-67 and to analyse the correlation between Ki-67 index and the other conventional prognostic factors in br...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2019-10-01
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| Series: | European Journal of Breast Health |
| Subjects: | |
| Online Access: |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/prognostic-mportance-of-ki-67-in-breast-cancer-and/41965
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| _version_ | 1797924031504056320 |
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| author | Gül Kanyılmaz Berrin Benli Yavuz Meryem Aktan Mustafa Karaağaç Mehmet Uyar Sıddıka Fındık |
| author_facet | Gül Kanyılmaz Berrin Benli Yavuz Meryem Aktan Mustafa Karaağaç Mehmet Uyar Sıddıka Fındık |
| author_sort | Gül Kanyılmaz |
| collection | DOAJ |
| description | Objective:The clinical feature of breast cancer is very heterogeneous because of the variable prognostic factors impact its behaviour. The aim of study is to find the prognostic importance of Ki-67 and to analyse the correlation between Ki-67 index and the other conventional prognostic factors in breast cancer patients.Materials and Methods: Between 2010 and 2017, patients with invasive ductal carcinoma who received radiotherapy after surgery were included in study. A single pathologist re-defined of all cases retrospectively. Ki-67 were established three categories based on Ki-67 levels: low (<10%), intermediate (10-25%) and high (>25%).Results: A total of 258 patients were included. 46 of 258 (18%) patients were in low, 82 of 258 (32%) patients were in intermediate and 130 of 258 (50%) patients were in high Ki-67 group. There were no correlations between menopausal status, age, and Ki-67 level. Low-pT stages tended to have low Ki-67 expression (p=0.07). Low-pN stages correlated with low Ki-67 values (p=0.007). Patients with ECE (+) were prone to have higher Ki-67 values (p=0.02). The significant correlation was seen between Ki-67 and tumour grading (p=<0.0001). Patients with LVI (+) had higher Ki-67 expression (p=0.007). Luminal A tumours were correlated with low Ki-67 group (p=<0.0001). Ki-67 values had significant effect on DFS (p=0.03) but not OS (p=0.09).Conclusion: This study showed that high Ki-67 expression is associated with higher pT-stage, higher pN-stage, higher grade, ER/PR negativity, HER2/neu positivity, ECE and LVI positivity. The prognostic impact of Ki-67 was only demonstrated for DFS. |
| first_indexed | 2024-04-10T14:55:20Z |
| format | Article |
| id | doaj.art-4450ec2676b94ab38d4bb05f74876903 |
| institution | Directory Open Access Journal |
| issn | 2587-0831 |
| language | English |
| last_indexed | 2024-04-10T14:55:20Z |
| publishDate | 2019-10-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj.art-4450ec2676b94ab38d4bb05f748769032023-02-15T16:07:23ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312019-10-0115425626110.5152/ejbh.2019.477813049054Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic FactorsGül Kanyılmaz0Berrin Benli Yavuz1Meryem Aktan2Mustafa Karaağaç3Mehmet Uyar4Sıddıka Fındık5 Department of Radiation Oncology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey Department of Radiation Oncology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey Department of Radiation Oncology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey Department of Clinical Oncology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey Department of Public Health and Biostatistics, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey Department of Pathology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey Objective:The clinical feature of breast cancer is very heterogeneous because of the variable prognostic factors impact its behaviour. The aim of study is to find the prognostic importance of Ki-67 and to analyse the correlation between Ki-67 index and the other conventional prognostic factors in breast cancer patients.Materials and Methods: Between 2010 and 2017, patients with invasive ductal carcinoma who received radiotherapy after surgery were included in study. A single pathologist re-defined of all cases retrospectively. Ki-67 were established three categories based on Ki-67 levels: low (<10%), intermediate (10-25%) and high (>25%).Results: A total of 258 patients were included. 46 of 258 (18%) patients were in low, 82 of 258 (32%) patients were in intermediate and 130 of 258 (50%) patients were in high Ki-67 group. There were no correlations between menopausal status, age, and Ki-67 level. Low-pT stages tended to have low Ki-67 expression (p=0.07). Low-pN stages correlated with low Ki-67 values (p=0.007). Patients with ECE (+) were prone to have higher Ki-67 values (p=0.02). The significant correlation was seen between Ki-67 and tumour grading (p=<0.0001). Patients with LVI (+) had higher Ki-67 expression (p=0.007). Luminal A tumours were correlated with low Ki-67 group (p=<0.0001). Ki-67 values had significant effect on DFS (p=0.03) but not OS (p=0.09).Conclusion: This study showed that high Ki-67 expression is associated with higher pT-stage, higher pN-stage, higher grade, ER/PR negativity, HER2/neu positivity, ECE and LVI positivity. The prognostic impact of Ki-67 was only demonstrated for DFS. http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/prognostic-mportance-of-ki-67-in-breast-cancer-and/41965 breast cancerki-67prognostic factorsradiotherapysurvival |
| spellingShingle | Gül Kanyılmaz Berrin Benli Yavuz Meryem Aktan Mustafa Karaağaç Mehmet Uyar Sıddıka Fındık Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factors European Journal of Breast Health breast cancer ki-67 prognostic factors radiotherapy survival |
| title | Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factors |
| title_full | Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factors |
| title_fullStr | Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factors |
| title_full_unstemmed | Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factors |
| title_short | Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factors |
| title_sort | prognostic importance of ki 67 in breast cancer and its relationship with other prognostic factors |
| topic | breast cancer ki-67 prognostic factors radiotherapy survival |
| url |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/prognostic-mportance-of-ki-67-in-breast-cancer-and/41965
|
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