How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and “tomorrow” [version 1; referees: 2 approved]
Bronchopulmonary dysplasia, or BPD, is the most common chronic lung disease in infants. Genetic predisposition and developmental vulnerability secondary to antenatal and postnatal infections, compounded with exposure to hyperoxia and invasive mechanical ventilation to an immature lung, result in per...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-04-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/6-539/v1 |
| _version_ | 1818107502519123968 |
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| author | Leif D. Nelin Vineet Bhandari |
| author_facet | Leif D. Nelin Vineet Bhandari |
| author_sort | Leif D. Nelin |
| collection | DOAJ |
| description | Bronchopulmonary dysplasia, or BPD, is the most common chronic lung disease in infants. Genetic predisposition and developmental vulnerability secondary to antenatal and postnatal infections, compounded with exposure to hyperoxia and invasive mechanical ventilation to an immature lung, result in persistent inflammation, culminating in the characteristic pulmonary phenotype of BPD of impaired alveolarization and dysregulated vascularization. In this article, we highlight specific areas in current management, and speculate on therapeutic strategies that are on the horizon, that we believe will make an impact in decreasing the incidence of BPD in your neonatal intensive care units. |
| first_indexed | 2024-12-11T02:00:29Z |
| format | Article |
| id | doaj.art-445106e3d2aa4e0db9bee95e4754aed0 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-11T02:00:29Z |
| publishDate | 2017-04-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-445106e3d2aa4e0db9bee95e4754aed02022-12-22T01:24:30ZengF1000 Research LtdF1000Research2046-14022017-04-01610.12688/f1000research.10832.111681How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and “tomorrow” [version 1; referees: 2 approved]Leif D. Nelin0Vineet Bhandari1Section of Neonatology, Department of Pediatrics, Nationwide Children’s Hospital, The Ohio State University College of Medicine, Columbus, OH, USASection of Neonatology, Department of Pediatrics, St. Christopher’s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA, USABronchopulmonary dysplasia, or BPD, is the most common chronic lung disease in infants. Genetic predisposition and developmental vulnerability secondary to antenatal and postnatal infections, compounded with exposure to hyperoxia and invasive mechanical ventilation to an immature lung, result in persistent inflammation, culminating in the characteristic pulmonary phenotype of BPD of impaired alveolarization and dysregulated vascularization. In this article, we highlight specific areas in current management, and speculate on therapeutic strategies that are on the horizon, that we believe will make an impact in decreasing the incidence of BPD in your neonatal intensive care units.https://f1000research.com/articles/6-539/v1Nosocomial & Healthcare-Associated InfectionsPediatric Infectious DiseasesPediatric Problems in Critical CarePregnancy, Labor, Delivery & Postpartum CareRespiratory PediatricsRespiratory Problems in Critical CareSexually Transmitted Diseases (without HIV) |
| spellingShingle | Leif D. Nelin Vineet Bhandari How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and “tomorrow” [version 1; referees: 2 approved] F1000Research Nosocomial & Healthcare-Associated Infections Pediatric Infectious Diseases Pediatric Problems in Critical Care Pregnancy, Labor, Delivery & Postpartum Care Respiratory Pediatrics Respiratory Problems in Critical Care Sexually Transmitted Diseases (without HIV) |
| title | How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and “tomorrow” [version 1; referees: 2 approved] |
| title_full | How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and “tomorrow” [version 1; referees: 2 approved] |
| title_fullStr | How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and “tomorrow” [version 1; referees: 2 approved] |
| title_full_unstemmed | How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and “tomorrow” [version 1; referees: 2 approved] |
| title_short | How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and “tomorrow” [version 1; referees: 2 approved] |
| title_sort | how to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and tomorrow version 1 referees 2 approved |
| topic | Nosocomial & Healthcare-Associated Infections Pediatric Infectious Diseases Pediatric Problems in Critical Care Pregnancy, Labor, Delivery & Postpartum Care Respiratory Pediatrics Respiratory Problems in Critical Care Sexually Transmitted Diseases (without HIV) |
| url | https://f1000research.com/articles/6-539/v1 |
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