Compensatory effort parallels midbrain deactivation during mental fatigue: an fMRI study.
Fatigue reflects the functioning of our physiological negative feedback system, which prevents us from overworking. When fatigued, however, we often try to suppress this system in an effort to compensate for the resulting deterioration in performance. Previous studies have suggested that the effect...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3573002?pdf=render |
| _version_ | 1818174337549598720 |
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| author | Seishu Nakagawa Motoaki Sugiura Yuko Akitsuki S M Hadi Hosseini Yuka Kotozaki Carlos Makoto Miyauchi Yukihito Yomogida Ryoichi Yokoyama Hikaru Takeuchi Ryuta Kawashima |
| author_facet | Seishu Nakagawa Motoaki Sugiura Yuko Akitsuki S M Hadi Hosseini Yuka Kotozaki Carlos Makoto Miyauchi Yukihito Yomogida Ryoichi Yokoyama Hikaru Takeuchi Ryuta Kawashima |
| author_sort | Seishu Nakagawa |
| collection | DOAJ |
| description | Fatigue reflects the functioning of our physiological negative feedback system, which prevents us from overworking. When fatigued, however, we often try to suppress this system in an effort to compensate for the resulting deterioration in performance. Previous studies have suggested that the effect of fatigue on neurovascular demand may be influenced by this compensatory effort. The primary goal of the present study was to isolate the effect of compensatory effort on neurovascular demand. Healthy male volunteers participated in a series of visual and auditory divided attention tasks that steadily increased fatigue levels for 2 hours. Functional magnetic resonance imaging scans were performed during the first and last quarter of the study (Pre and Post sessions, respectively). Tasks with low and high attentional load (Low and High conditions, respectively) were administrated in alternating blocks. We assumed that compensatory effort would be greater under the High-attentional-load condition compared with the Low-load condition. The difference was assessed during the two sessions. The effect of compensatory effort on neurovascular demand was evaluated by examining the interaction between load (High vs. Low) and time (Pre vs. Post). Significant fatigue-induced deactivation (i.e., Pre>Post) was observed in the frontal, temporal, occipital, and parietal cortices, in the cerebellum, and in the midbrain in both the High and Low conditions. The interaction was significantly greater in the High than in the Low condition in the midbrain. Neither significant fatigue-induced activation (i.e., Pre<Post), nor its interaction with factor Load, was identified. The observed midbrain deactivation ([PreH - PostH]>[PreE- PostE]) may reflect suppression of the negative feedback system that normally triggers recuperative rest to maintain homeostasis. |
| first_indexed | 2024-12-11T19:42:48Z |
| format | Article |
| id | doaj.art-4451be5511604f12a3af98a5eb9431df |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T19:42:48Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4451be5511604f12a3af98a5eb9431df2022-12-22T00:52:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5660610.1371/journal.pone.0056606Compensatory effort parallels midbrain deactivation during mental fatigue: an fMRI study.Seishu NakagawaMotoaki SugiuraYuko AkitsukiS M Hadi HosseiniYuka KotozakiCarlos Makoto MiyauchiYukihito YomogidaRyoichi YokoyamaHikaru TakeuchiRyuta KawashimaFatigue reflects the functioning of our physiological negative feedback system, which prevents us from overworking. When fatigued, however, we often try to suppress this system in an effort to compensate for the resulting deterioration in performance. Previous studies have suggested that the effect of fatigue on neurovascular demand may be influenced by this compensatory effort. The primary goal of the present study was to isolate the effect of compensatory effort on neurovascular demand. Healthy male volunteers participated in a series of visual and auditory divided attention tasks that steadily increased fatigue levels for 2 hours. Functional magnetic resonance imaging scans were performed during the first and last quarter of the study (Pre and Post sessions, respectively). Tasks with low and high attentional load (Low and High conditions, respectively) were administrated in alternating blocks. We assumed that compensatory effort would be greater under the High-attentional-load condition compared with the Low-load condition. The difference was assessed during the two sessions. The effect of compensatory effort on neurovascular demand was evaluated by examining the interaction between load (High vs. Low) and time (Pre vs. Post). Significant fatigue-induced deactivation (i.e., Pre>Post) was observed in the frontal, temporal, occipital, and parietal cortices, in the cerebellum, and in the midbrain in both the High and Low conditions. The interaction was significantly greater in the High than in the Low condition in the midbrain. Neither significant fatigue-induced activation (i.e., Pre<Post), nor its interaction with factor Load, was identified. The observed midbrain deactivation ([PreH - PostH]>[PreE- PostE]) may reflect suppression of the negative feedback system that normally triggers recuperative rest to maintain homeostasis.http://europepmc.org/articles/PMC3573002?pdf=render |
| spellingShingle | Seishu Nakagawa Motoaki Sugiura Yuko Akitsuki S M Hadi Hosseini Yuka Kotozaki Carlos Makoto Miyauchi Yukihito Yomogida Ryoichi Yokoyama Hikaru Takeuchi Ryuta Kawashima Compensatory effort parallels midbrain deactivation during mental fatigue: an fMRI study. PLoS ONE |
| title | Compensatory effort parallels midbrain deactivation during mental fatigue: an fMRI study. |
| title_full | Compensatory effort parallels midbrain deactivation during mental fatigue: an fMRI study. |
| title_fullStr | Compensatory effort parallels midbrain deactivation during mental fatigue: an fMRI study. |
| title_full_unstemmed | Compensatory effort parallels midbrain deactivation during mental fatigue: an fMRI study. |
| title_short | Compensatory effort parallels midbrain deactivation during mental fatigue: an fMRI study. |
| title_sort | compensatory effort parallels midbrain deactivation during mental fatigue an fmri study |
| url | http://europepmc.org/articles/PMC3573002?pdf=render |
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