Anti-inflammatory mechanisms of IFN-γ studied in experimental autoimmune encephalomyelitis reveal neutrophils as a potential target in multiple sclerosis

Anti-inflammatory mechanisms of IFN-γ studied in experimental autoimmune encephalomyelitis reveal neutrophils as a potential target in multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) mediated by T helper (h)1 and/or Th17 CD4 T cells that drive inflammatory lesion development along with demyelination and neuronal damage. Defects in immune regulatory mechanisms are thought to play a role in the p...

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Bibliographic Details
Main Authors: Nichole M Miller, Jun eWang, Yanping eTan, Bonnie N Dittel
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Neuroscience
Subjects:
Multiple Sclerosis
Neutrophils
Experimental autoimmune encephalomyelitis
anti-inflammatory
IFN-γ
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00287/full

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