Positive Effect of Cognitive Training in Older Adults with Different <i>APOE</i> Genotypes and COVID-19 History: A 1-Year Follow-Up Cohort Study
(1) Background: Older people suffer from cognitive decline; several risk factors contribute to greater cognitive decline. We used acquired (COVID-19 infection) and non-modifiable (presence of <i>APOE</i> rs429358 and rs7412 polymorphisms) factors to study the progression of subjective co...
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| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/10/2312 |
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| author | Yana Zorkina Timur Syunyakov Olga Abramova Alisa Andryushchenko Denis Andreuyk Evgeniya Abbazova Dmitry Goncharov Alisa Rakova Nika Andriushchenko Dmitry Gryadunov Anna Ikonnikova Elena Fedoseeva Marina Emelyanova Kristina Soloveva Konstantin Pavlov Olga Karpenko Victor Savilov Marat Kurmishev Olga Gurina Vladimir Chekhonin Georgy Kostyuk Anna Morozova |
| author_facet | Yana Zorkina Timur Syunyakov Olga Abramova Alisa Andryushchenko Denis Andreuyk Evgeniya Abbazova Dmitry Goncharov Alisa Rakova Nika Andriushchenko Dmitry Gryadunov Anna Ikonnikova Elena Fedoseeva Marina Emelyanova Kristina Soloveva Konstantin Pavlov Olga Karpenko Victor Savilov Marat Kurmishev Olga Gurina Vladimir Chekhonin Georgy Kostyuk Anna Morozova |
| author_sort | Yana Zorkina |
| collection | DOAJ |
| description | (1) Background: Older people suffer from cognitive decline; several risk factors contribute to greater cognitive decline. We used acquired (COVID-19 infection) and non-modifiable (presence of <i>APOE</i> rs429358 and rs7412 polymorphisms) factors to study the progression of subjective cognitive impairment while observing patients for one year. Cognitive training was used as a protective factor. (2) Methods: Two groups of subjects over the age of 65 participated in the study: group with subjective cognitive decline receiving cognitive training and individuals who did not complain of cognitive decline without receiving cognitive training (comparison group). On the first visit, the concentration of antibodies to COVID-19 and <i>APOE</i> genotype was measured. At the first and last point (1 year later) the Mini-Mental State Examination scale and the Hospital Anxiety and Depression Scale were performed. (3) Results: COVID-19 infection did not affect cognitive function. A significant role of cognitive training in improving cognitive functions was revealed. Older adults with <i>APOE-ε4</i> genotype showed no positive effect of cognitive training. (4) Conclusions: Future research should focus on cognitive dysfunction after COVID-19 in long-term follow-up. Attention to the factors discussed in our article, but not limited to them, are useful for a personalized approach to maintaining the cognitive health of older adults. |
| first_indexed | 2024-03-09T20:23:11Z |
| format | Article |
| id | doaj.art-4454692bfb69487698c6fc0c43f92799 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T20:23:11Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-4454692bfb69487698c6fc0c43f927992023-11-23T23:43:06ZengMDPI AGDiagnostics2075-44182022-09-011210231210.3390/diagnostics12102312Positive Effect of Cognitive Training in Older Adults with Different <i>APOE</i> Genotypes and COVID-19 History: A 1-Year Follow-Up Cohort StudyYana Zorkina0Timur Syunyakov1Olga Abramova2Alisa Andryushchenko3Denis Andreuyk4Evgeniya Abbazova5Dmitry Goncharov6Alisa Rakova7Nika Andriushchenko8Dmitry Gryadunov9Anna Ikonnikova10Elena Fedoseeva11Marina Emelyanova12Kristina Soloveva13Konstantin Pavlov14Olga Karpenko15Victor Savilov16Marat Kurmishev17Olga Gurina18Vladimir Chekhonin19Georgy Kostyuk20Anna Morozova21Mental-Health Clinic No. 1 Named after N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named after N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named after N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named after N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named after N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaN.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of Russia, Gamaleya st. 18, 123098 Moscow, RussiaN.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of Russia, Gamaleya st. 18, 123098 Moscow, RussiaN.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of Russia, Gamaleya st. 18, 123098 Moscow, RussiaDepartment of Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Kropotkinsky per. 23, 119034 Moscow, RussiaCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, RussiaCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, RussiaCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, RussiaCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, RussiaMental-Health Clinic No. 1 Named after N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaDepartment of Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Kropotkinsky per. 23, 119034 Moscow, RussiaMental-Health Clinic No. 1 Named after N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named after N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named after N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaDepartment of Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Kropotkinsky per. 23, 119034 Moscow, RussiaDepartment of Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Kropotkinsky per. 23, 119034 Moscow, RussiaMental-Health Clinic No. 1 Named after N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named after N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, Russia(1) Background: Older people suffer from cognitive decline; several risk factors contribute to greater cognitive decline. We used acquired (COVID-19 infection) and non-modifiable (presence of <i>APOE</i> rs429358 and rs7412 polymorphisms) factors to study the progression of subjective cognitive impairment while observing patients for one year. Cognitive training was used as a protective factor. (2) Methods: Two groups of subjects over the age of 65 participated in the study: group with subjective cognitive decline receiving cognitive training and individuals who did not complain of cognitive decline without receiving cognitive training (comparison group). On the first visit, the concentration of antibodies to COVID-19 and <i>APOE</i> genotype was measured. At the first and last point (1 year later) the Mini-Mental State Examination scale and the Hospital Anxiety and Depression Scale were performed. (3) Results: COVID-19 infection did not affect cognitive function. A significant role of cognitive training in improving cognitive functions was revealed. Older adults with <i>APOE-ε4</i> genotype showed no positive effect of cognitive training. (4) Conclusions: Future research should focus on cognitive dysfunction after COVID-19 in long-term follow-up. Attention to the factors discussed in our article, but not limited to them, are useful for a personalized approach to maintaining the cognitive health of older adults.https://www.mdpi.com/2075-4418/12/10/2312MCICOVID-19SARS-CoV-2<i>APOE</i>rs429358rs7412 |
| spellingShingle | Yana Zorkina Timur Syunyakov Olga Abramova Alisa Andryushchenko Denis Andreuyk Evgeniya Abbazova Dmitry Goncharov Alisa Rakova Nika Andriushchenko Dmitry Gryadunov Anna Ikonnikova Elena Fedoseeva Marina Emelyanova Kristina Soloveva Konstantin Pavlov Olga Karpenko Victor Savilov Marat Kurmishev Olga Gurina Vladimir Chekhonin Georgy Kostyuk Anna Morozova Positive Effect of Cognitive Training in Older Adults with Different <i>APOE</i> Genotypes and COVID-19 History: A 1-Year Follow-Up Cohort Study Diagnostics MCI COVID-19 SARS-CoV-2 <i>APOE</i> rs429358 rs7412 |
| title | Positive Effect of Cognitive Training in Older Adults with Different <i>APOE</i> Genotypes and COVID-19 History: A 1-Year Follow-Up Cohort Study |
| title_full | Positive Effect of Cognitive Training in Older Adults with Different <i>APOE</i> Genotypes and COVID-19 History: A 1-Year Follow-Up Cohort Study |
| title_fullStr | Positive Effect of Cognitive Training in Older Adults with Different <i>APOE</i> Genotypes and COVID-19 History: A 1-Year Follow-Up Cohort Study |
| title_full_unstemmed | Positive Effect of Cognitive Training in Older Adults with Different <i>APOE</i> Genotypes and COVID-19 History: A 1-Year Follow-Up Cohort Study |
| title_short | Positive Effect of Cognitive Training in Older Adults with Different <i>APOE</i> Genotypes and COVID-19 History: A 1-Year Follow-Up Cohort Study |
| title_sort | positive effect of cognitive training in older adults with different i apoe i genotypes and covid 19 history a 1 year follow up cohort study |
| topic | MCI COVID-19 SARS-CoV-2 <i>APOE</i> rs429358 rs7412 |
| url | https://www.mdpi.com/2075-4418/12/10/2312 |
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