Perspective: Contribution of Epstein–Barr virus (EBV) Reactivation to the Carcinogenicity of Nasopharyngeal Cancer Cells
Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma derived from the epithelium of the post-nasal cavity, with a unique geographic and ethnic distribution. Epstein–Barr virus (EBV) is an etiological agent of NPC, but how it contributes to carcinogenesis is not completely clear. Alt...
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| Format: | Article |
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MDPI AG
2018-04-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/10/4/120 |
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| author | Chung-Chun Wu Chih-Yeu Fang Sheng-Yen Huang Shih-Hsin Chiu Chia-Huei Lee Jen-Yang Chen |
| author_facet | Chung-Chun Wu Chih-Yeu Fang Sheng-Yen Huang Shih-Hsin Chiu Chia-Huei Lee Jen-Yang Chen |
| author_sort | Chung-Chun Wu |
| collection | DOAJ |
| description | Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma derived from the epithelium of the post-nasal cavity, with a unique geographic and ethnic distribution. Epstein–Barr virus (EBV) is an etiological agent of NPC, but how it contributes to carcinogenesis is not completely clear. Although it is thought that EBV latency participates in the development of NPC, increasing evidence reveals that the lytic cycle also plays an important role in the carcinogenic process. In this review, we summarize our recent studies on how EBV reactivation causes genomic instability and accelerates tumorigenesis in epithelial cells. The roles of three lytic genes, namely, BRLF1, BGLF5 and BALF3, in this process are also introduced. Moreover, blocking EBV reactivation using natural compounds may help delay the progression of NPC tumorigenesis. These studies provide a new insight into NPC carcinogenesis and raise the possibility that inhibition of EBV reactivation may be a novel approach to prevent the relapse of NPC. |
| first_indexed | 2024-03-12T11:19:35Z |
| format | Article |
| id | doaj.art-445554c8f8c948f78cffc50e8150de28 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T11:19:35Z |
| publishDate | 2018-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-445554c8f8c948f78cffc50e8150de282023-09-02T01:20:50ZengMDPI AGCancers2072-66942018-04-0110412010.3390/cancers10040120cancers10040120Perspective: Contribution of Epstein–Barr virus (EBV) Reactivation to the Carcinogenicity of Nasopharyngeal Cancer CellsChung-Chun Wu0Chih-Yeu Fang1Sheng-Yen Huang2Shih-Hsin Chiu3Chia-Huei Lee4Jen-Yang Chen5National Institute of Cancer Research, National Health Research Institutes, Zhunan 350, TaiwanDepartment of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei 116, TaiwanNational Institute of Cancer Research, National Health Research Institutes, Zhunan 350, TaiwanNational Institute of Cancer Research, National Health Research Institutes, Zhunan 350, TaiwanNational Institute of Cancer Research, National Health Research Institutes, Zhunan 350, TaiwanNational Institute of Cancer Research, National Health Research Institutes, Zhunan 350, TaiwanNasopharyngeal carcinoma (NPC) is a squamous cell carcinoma derived from the epithelium of the post-nasal cavity, with a unique geographic and ethnic distribution. Epstein–Barr virus (EBV) is an etiological agent of NPC, but how it contributes to carcinogenesis is not completely clear. Although it is thought that EBV latency participates in the development of NPC, increasing evidence reveals that the lytic cycle also plays an important role in the carcinogenic process. In this review, we summarize our recent studies on how EBV reactivation causes genomic instability and accelerates tumorigenesis in epithelial cells. The roles of three lytic genes, namely, BRLF1, BGLF5 and BALF3, in this process are also introduced. Moreover, blocking EBV reactivation using natural compounds may help delay the progression of NPC tumorigenesis. These studies provide a new insight into NPC carcinogenesis and raise the possibility that inhibition of EBV reactivation may be a novel approach to prevent the relapse of NPC.http://www.mdpi.com/2072-6694/10/4/120Epstein–Barr virusreactivationlytic cyclegenomic instabilitynasopharyngeal carcinoma |
| spellingShingle | Chung-Chun Wu Chih-Yeu Fang Sheng-Yen Huang Shih-Hsin Chiu Chia-Huei Lee Jen-Yang Chen Perspective: Contribution of Epstein–Barr virus (EBV) Reactivation to the Carcinogenicity of Nasopharyngeal Cancer Cells Cancers Epstein–Barr virus reactivation lytic cycle genomic instability nasopharyngeal carcinoma |
| title | Perspective: Contribution of Epstein–Barr virus (EBV) Reactivation to the Carcinogenicity of Nasopharyngeal Cancer Cells |
| title_full | Perspective: Contribution of Epstein–Barr virus (EBV) Reactivation to the Carcinogenicity of Nasopharyngeal Cancer Cells |
| title_fullStr | Perspective: Contribution of Epstein–Barr virus (EBV) Reactivation to the Carcinogenicity of Nasopharyngeal Cancer Cells |
| title_full_unstemmed | Perspective: Contribution of Epstein–Barr virus (EBV) Reactivation to the Carcinogenicity of Nasopharyngeal Cancer Cells |
| title_short | Perspective: Contribution of Epstein–Barr virus (EBV) Reactivation to the Carcinogenicity of Nasopharyngeal Cancer Cells |
| title_sort | perspective contribution of epstein barr virus ebv reactivation to the carcinogenicity of nasopharyngeal cancer cells |
| topic | Epstein–Barr virus reactivation lytic cycle genomic instability nasopharyngeal carcinoma |
| url | http://www.mdpi.com/2072-6694/10/4/120 |
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