Articular Cartilage Regeneration through Bioassembling Spherical Micro-Cartilage Building Blocks
Articular cartilage lesions are prevalent and affect one out of seven American adults and many young patients. Cartilage is not capable of regeneration on its own. Existing therapeutic approaches for articular cartilage lesions have limitations. Cartilage tissue engineering is a promising approach f...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/20/3244 |
| _version_ | 1827651019069194240 |
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| author | Brian E. Grottkau Zhixin Hui Yonggang Pang |
| author_facet | Brian E. Grottkau Zhixin Hui Yonggang Pang |
| author_sort | Brian E. Grottkau |
| collection | DOAJ |
| description | Articular cartilage lesions are prevalent and affect one out of seven American adults and many young patients. Cartilage is not capable of regeneration on its own. Existing therapeutic approaches for articular cartilage lesions have limitations. Cartilage tissue engineering is a promising approach for regenerating articular neocartilage. Bioassembly is an emerging technology that uses microtissues or micro-precursor tissues as building blocks to construct a macro-tissue. We summarize and highlight the application of bioassembly technology in regenerating articular cartilage. We discuss the advantages of bioassembly and present two types of building blocks: multiple cellular scaffold-free spheroids and cell-laden polymer or hydrogel microspheres. We present techniques for generating building blocks and bioassembly methods, including bioprinting and non-bioprinting techniques. Using a data set of 5069 articles from the last 28 years of literature, we analyzed seven categories of related research, and the year trends are presented. The limitations and future directions of this technology are also discussed. |
| first_indexed | 2024-03-09T20:28:59Z |
| format | Article |
| id | doaj.art-4457861c0dad41c3afbefc8bff4cd937 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T20:28:59Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4457861c0dad41c3afbefc8bff4cd9372023-11-23T23:27:57ZengMDPI AGCells2073-44092022-10-011120324410.3390/cells11203244Articular Cartilage Regeneration through Bioassembling Spherical Micro-Cartilage Building BlocksBrian E. Grottkau0Zhixin Hui1Yonggang Pang2The Laboratory for Therapeutic 3D Bioprinting, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St., Boston, MA 02114, USAThe Laboratory for Therapeutic 3D Bioprinting, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St., Boston, MA 02114, USAThe Laboratory for Therapeutic 3D Bioprinting, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St., Boston, MA 02114, USAArticular cartilage lesions are prevalent and affect one out of seven American adults and many young patients. Cartilage is not capable of regeneration on its own. Existing therapeutic approaches for articular cartilage lesions have limitations. Cartilage tissue engineering is a promising approach for regenerating articular neocartilage. Bioassembly is an emerging technology that uses microtissues or micro-precursor tissues as building blocks to construct a macro-tissue. We summarize and highlight the application of bioassembly technology in regenerating articular cartilage. We discuss the advantages of bioassembly and present two types of building blocks: multiple cellular scaffold-free spheroids and cell-laden polymer or hydrogel microspheres. We present techniques for generating building blocks and bioassembly methods, including bioprinting and non-bioprinting techniques. Using a data set of 5069 articles from the last 28 years of literature, we analyzed seven categories of related research, and the year trends are presented. The limitations and future directions of this technology are also discussed.https://www.mdpi.com/2073-4409/11/20/3244articular cartilage regenerationbioassemblyspherical micro-cartilagebuilding blocks3D bioprinting |
| spellingShingle | Brian E. Grottkau Zhixin Hui Yonggang Pang Articular Cartilage Regeneration through Bioassembling Spherical Micro-Cartilage Building Blocks Cells articular cartilage regeneration bioassembly spherical micro-cartilage building blocks 3D bioprinting |
| title | Articular Cartilage Regeneration through Bioassembling Spherical Micro-Cartilage Building Blocks |
| title_full | Articular Cartilage Regeneration through Bioassembling Spherical Micro-Cartilage Building Blocks |
| title_fullStr | Articular Cartilage Regeneration through Bioassembling Spherical Micro-Cartilage Building Blocks |
| title_full_unstemmed | Articular Cartilage Regeneration through Bioassembling Spherical Micro-Cartilage Building Blocks |
| title_short | Articular Cartilage Regeneration through Bioassembling Spherical Micro-Cartilage Building Blocks |
| title_sort | articular cartilage regeneration through bioassembling spherical micro cartilage building blocks |
| topic | articular cartilage regeneration bioassembly spherical micro-cartilage building blocks 3D bioprinting |
| url | https://www.mdpi.com/2073-4409/11/20/3244 |
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