The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation

Sleep plays important roles in sensory and motor memory consolidation. Sleep oscillations, reflecting neural population activity, involve the reactivation of learning-related neurons and regulate synaptic strength and, thereby affect memory consolidation. Among sleep oscillations, slow waves (0.5–4...

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Main Authors: Daisuke Miyamoto, Daichi Hirai, Masanori Murayama
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Neural Circuits
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fncir.2017.00092/full
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author Daisuke Miyamoto
Daisuke Miyamoto
Daichi Hirai
Masanori Murayama
author_facet Daisuke Miyamoto
Daisuke Miyamoto
Daichi Hirai
Masanori Murayama
author_sort Daisuke Miyamoto
collection DOAJ
description Sleep plays important roles in sensory and motor memory consolidation. Sleep oscillations, reflecting neural population activity, involve the reactivation of learning-related neurons and regulate synaptic strength and, thereby affect memory consolidation. Among sleep oscillations, slow waves (0.5–4 Hz) are closely associated with memory consolidation. For example, slow-wave power is regulated in an experience-dependent manner and correlates with acquired memory. Furthermore, manipulating slow waves can enhance or impair memory consolidation. During slow wave sleep, inter-areal interactions between the cortex and hippocampus (HC) have been proposed to consolidate declarative memory; however, interactions for non-declarative (HC-independent) memory remain largely uninvestigated. We recently showed that the directional influence in a slow-wave range through a top-down cortical long-range circuit is involved in the consolidation of non-declarative memory. At the synaptic level, the average cortical synaptic strength is known to be potentiated during wakefulness and depressed during sleep. Moreover, learning causes plasticity in a subset of synapses, allocating memory to them. Sleep may help to differentiate synaptic strength between allocated and non-allocated synapses (i.e., improving the signal-to-noise ratio, which may facilitate memory consolidation). Herein, we offer perspectives on inter-areal interactions and synaptic plasticity for memory consolidation during sleep.
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spelling doaj.art-445861af628846269d2e614a064abf6f2022-12-21T23:32:00ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102017-11-011110.3389/fncir.2017.00092286468The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory ConsolidationDaisuke Miyamoto0Daisuke Miyamoto1Daichi Hirai2Masanori Murayama3Laboratory for Behavioral Neurophysiology, RIKEN Brain Science Institute, Wako, JapanJapan Society for the Promotion of Science (JSPS), Tokyo, JapanLaboratory for Behavioral Neurophysiology, RIKEN Brain Science Institute, Wako, JapanLaboratory for Behavioral Neurophysiology, RIKEN Brain Science Institute, Wako, JapanSleep plays important roles in sensory and motor memory consolidation. Sleep oscillations, reflecting neural population activity, involve the reactivation of learning-related neurons and regulate synaptic strength and, thereby affect memory consolidation. Among sleep oscillations, slow waves (0.5–4 Hz) are closely associated with memory consolidation. For example, slow-wave power is regulated in an experience-dependent manner and correlates with acquired memory. Furthermore, manipulating slow waves can enhance or impair memory consolidation. During slow wave sleep, inter-areal interactions between the cortex and hippocampus (HC) have been proposed to consolidate declarative memory; however, interactions for non-declarative (HC-independent) memory remain largely uninvestigated. We recently showed that the directional influence in a slow-wave range through a top-down cortical long-range circuit is involved in the consolidation of non-declarative memory. At the synaptic level, the average cortical synaptic strength is known to be potentiated during wakefulness and depressed during sleep. Moreover, learning causes plasticity in a subset of synapses, allocating memory to them. Sleep may help to differentiate synaptic strength between allocated and non-allocated synapses (i.e., improving the signal-to-noise ratio, which may facilitate memory consolidation). Herein, we offer perspectives on inter-areal interactions and synaptic plasticity for memory consolidation during sleep.http://journal.frontiersin.org/article/10.3389/fncir.2017.00092/fullcortexhippocampusmemoryoscillationsleepsynaptic plasticity
spellingShingle Daisuke Miyamoto
Daisuke Miyamoto
Daichi Hirai
Masanori Murayama
The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation
Frontiers in Neural Circuits
cortex
hippocampus
memory
oscillation
sleep
synaptic plasticity
title The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation
title_full The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation
title_fullStr The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation
title_full_unstemmed The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation
title_short The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation
title_sort roles of cortical slow waves in synaptic plasticity and memory consolidation
topic cortex
hippocampus
memory
oscillation
sleep
synaptic plasticity
url http://journal.frontiersin.org/article/10.3389/fncir.2017.00092/full
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