The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation
Sleep plays important roles in sensory and motor memory consolidation. Sleep oscillations, reflecting neural population activity, involve the reactivation of learning-related neurons and regulate synaptic strength and, thereby affect memory consolidation. Among sleep oscillations, slow waves (0.5–4...
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Frontiers Media S.A.
2017-11-01
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Series: | Frontiers in Neural Circuits |
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Online Access: | http://journal.frontiersin.org/article/10.3389/fncir.2017.00092/full |
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author | Daisuke Miyamoto Daisuke Miyamoto Daichi Hirai Masanori Murayama |
author_facet | Daisuke Miyamoto Daisuke Miyamoto Daichi Hirai Masanori Murayama |
author_sort | Daisuke Miyamoto |
collection | DOAJ |
description | Sleep plays important roles in sensory and motor memory consolidation. Sleep oscillations, reflecting neural population activity, involve the reactivation of learning-related neurons and regulate synaptic strength and, thereby affect memory consolidation. Among sleep oscillations, slow waves (0.5–4 Hz) are closely associated with memory consolidation. For example, slow-wave power is regulated in an experience-dependent manner and correlates with acquired memory. Furthermore, manipulating slow waves can enhance or impair memory consolidation. During slow wave sleep, inter-areal interactions between the cortex and hippocampus (HC) have been proposed to consolidate declarative memory; however, interactions for non-declarative (HC-independent) memory remain largely uninvestigated. We recently showed that the directional influence in a slow-wave range through a top-down cortical long-range circuit is involved in the consolidation of non-declarative memory. At the synaptic level, the average cortical synaptic strength is known to be potentiated during wakefulness and depressed during sleep. Moreover, learning causes plasticity in a subset of synapses, allocating memory to them. Sleep may help to differentiate synaptic strength between allocated and non-allocated synapses (i.e., improving the signal-to-noise ratio, which may facilitate memory consolidation). Herein, we offer perspectives on inter-areal interactions and synaptic plasticity for memory consolidation during sleep. |
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institution | Directory Open Access Journal |
issn | 1662-5110 |
language | English |
last_indexed | 2024-12-13T20:45:38Z |
publishDate | 2017-11-01 |
publisher | Frontiers Media S.A. |
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series | Frontiers in Neural Circuits |
spelling | doaj.art-445861af628846269d2e614a064abf6f2022-12-21T23:32:00ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102017-11-011110.3389/fncir.2017.00092286468The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory ConsolidationDaisuke Miyamoto0Daisuke Miyamoto1Daichi Hirai2Masanori Murayama3Laboratory for Behavioral Neurophysiology, RIKEN Brain Science Institute, Wako, JapanJapan Society for the Promotion of Science (JSPS), Tokyo, JapanLaboratory for Behavioral Neurophysiology, RIKEN Brain Science Institute, Wako, JapanLaboratory for Behavioral Neurophysiology, RIKEN Brain Science Institute, Wako, JapanSleep plays important roles in sensory and motor memory consolidation. Sleep oscillations, reflecting neural population activity, involve the reactivation of learning-related neurons and regulate synaptic strength and, thereby affect memory consolidation. Among sleep oscillations, slow waves (0.5–4 Hz) are closely associated with memory consolidation. For example, slow-wave power is regulated in an experience-dependent manner and correlates with acquired memory. Furthermore, manipulating slow waves can enhance or impair memory consolidation. During slow wave sleep, inter-areal interactions between the cortex and hippocampus (HC) have been proposed to consolidate declarative memory; however, interactions for non-declarative (HC-independent) memory remain largely uninvestigated. We recently showed that the directional influence in a slow-wave range through a top-down cortical long-range circuit is involved in the consolidation of non-declarative memory. At the synaptic level, the average cortical synaptic strength is known to be potentiated during wakefulness and depressed during sleep. Moreover, learning causes plasticity in a subset of synapses, allocating memory to them. Sleep may help to differentiate synaptic strength between allocated and non-allocated synapses (i.e., improving the signal-to-noise ratio, which may facilitate memory consolidation). Herein, we offer perspectives on inter-areal interactions and synaptic plasticity for memory consolidation during sleep.http://journal.frontiersin.org/article/10.3389/fncir.2017.00092/fullcortexhippocampusmemoryoscillationsleepsynaptic plasticity |
spellingShingle | Daisuke Miyamoto Daisuke Miyamoto Daichi Hirai Masanori Murayama The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation Frontiers in Neural Circuits cortex hippocampus memory oscillation sleep synaptic plasticity |
title | The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation |
title_full | The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation |
title_fullStr | The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation |
title_full_unstemmed | The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation |
title_short | The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation |
title_sort | roles of cortical slow waves in synaptic plasticity and memory consolidation |
topic | cortex hippocampus memory oscillation sleep synaptic plasticity |
url | http://journal.frontiersin.org/article/10.3389/fncir.2017.00092/full |
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