An Innovative Fluid Dynamic System to Model Inflammation in Human Skin Explants

An Innovative Fluid Dynamic System to Model Inflammation in Human Skin Explants

Skin is a major administration route for drugs, and all transdermal formulations must be tested for their capability to overcome the cutaneous barrier. Therefore, developing highly reliable skin models is crucial for preclinical studies. The current in vitro models are unable to replicate the living...

Full description

Bibliographic Details
Main Authors:	Andrea Galvan, Enrica Cappellozza, Yann Pellequer, Anita Conti, Edoardo Dalla Pozza, Enrico Vigato, Manuela Malatesta, Laura Calderan
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Series:	International Journal of Molecular Sciences
Subjects:	bioreactor in vitro tissue preservation dithranol substance P light microscopy transmission electron microscopy
Online Access:	https://www.mdpi.com/1422-0067/24/7/6284

Similar Items

Ex Vivo Evaluation of Ethosomes and Transethosomes Applied on Human Skin: A Comparative Study
by: Elisabetta Esposito, et al.
Published: (2022-12-01)

Assessing the interactions between nanoparticles and biological barriers in vitro: a new challenge for microscopy techniques in nanomedicine
by: Flavia Carton, et al.
Published: (2022-11-01)

An <em>ex vivo</em> experimental system to track fluorescent nanoparticles inside skeletal muscle
by: Laura Calderan, et al.
Published: (2022-12-01)

Imaging techniques in nanomedical research
by: Laura Calderan, et al.
Published: (2020-07-01)

Effect of psoriasis activity and topical treatment on plasma epidermal growth factor (EGF) and its soluble receptor (sEGFR)
by: M. Szterling-Jaworowska, et al.
Published: (2018-02-01)

Synthesis of New 10-Arylthioanthralins and Oxidation of Thioanthralins to Their Corresponding Sulfones
by: Jabbar Khalafy, et al.
Published: (1996-06-01)

A spectrofluorometric analysis to evaluate transcutaneous biodistribution of fluorescent nanoparticulate gel formulations
by: Enrica Cappellozza, et al.
Published: (2022-02-01)

Electrospun PCL/PVA Coaxial Nanofibers with Embedded Titanium Dioxide and Magnetic Nanoparticles for Stabilization and Controlled Release of Dithranol for Therapy of Psoriasis
by: Natália Andrýsková, et al.
Published: (2023-07-01)

Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis
by: Theresa Benezeder, et al.
Published: (2020-06-01)

“Pigmented irritant contact dermatitis” − an issue of concern due to dithranol misuse in Andaman and Nicobar: an observational study
by: Pradeep Balasubramanian, et al.
Published: (2020-01-01)

Ozone at low concentrations does not affect motility and proliferation of cancer cells in vitro
by: Manuela Costanzo, et al.
Published: (2020-04-01)

Design, Synthesis and in Vitro Degradation of a Novel Co-Drug for the Treatment of Psoriasis
by: Alex W. White, et al.
Published: (2013-04-01)

Extracellular matrix surface network is associated with non-morphogenic calli of Helianthus tuberosus cv. Albik produced from various explants
by: Maria Pilarska, et al.
Published: (2014-03-01)

Ozone Activates the Nrf2 Pathway and Improves Preservation of Explanted Adipose Tissue In Vitro
by: Barbara Cisterna, et al.
Published: (2020-10-01)

Ultrastructural histochemistry in biomedical research: Alive and kicking
by: Manuela Malatesta
Published: (2018-11-01)

Histochemistry for nanomedicine: Novelty in tradition
by: Manuela Malatesta
Published: (2021-12-01)

Computational Design of a Novel Dithranol–Salicylic Acid Antipsoriatic Prodrug for Esterase-Activated Topical Drug Delivery
by: Natália Andrýsková, et al.
Published: (2024-01-01)

Formulative Study and Intracellular Fate Evaluation of Ethosomes and Transethosomes for Vitamin D3 Delivery
by: Manuela Costanzo, et al.
Published: (2021-05-01)

STRUCTURAL CHANGES OF RAT MEDULLA OF KIDNEY AT EXPERIMENTAL BURN TRAUMA OF SKIN AND AS THE INFUSION OF LACTOPROTEINUM WITH SORBYTOL
by: O. V. Malikov
Published: (2015-06-01)

Optimized dithranol-imiquimod-based transcutaneous immunization enables tumor rejection
by: Ann-Kathrin Hartmann, et al.
Published: (2023-09-01)

Satellite Cells in Skeletal Muscle of the Hibernating Dormouse, a Natural Model of Quiescence and Re-Activation: Focus on the Cell Nucleus
by: Manuela Malatesta, et al.
Published: (2020-04-01)

Cyclodextrin-Modified CeO2 Nanoparticles as a Multifunctional Nanozyme for Combinational Therapy of Psoriasis
by: Wu L, et al.
Published: (2020-04-01)

Low ozone concentrations promote adipogenesis in human adipose-derived adult stem cells
by: Manuela Costanzo, et al.
Published: (2018-09-01)

Comprehensive Study of the Structural Components of the Skin: From Routine Methods to Modern Microscopy Methods
by: Ekaterina S. Mishina, et al.
Published: (2021-06-01)

Effect of Spherical Elements of Biosensors and Bioreactors on the Physicochemical Properties of a Peroxidase Protein
by: Yuri D. Ivanov, et al.
Published: (2021-05-01)

Proceedings for 7th Asia Pacific Electron Microscopy Conference, 26-30 June 2000, Singapore International Convention & Exibition Centre, Suntec City, Singapore : perspective imaging
by: Asia Pacific Electron Microscopy Conference (7th : 2000 : Singapore)
Published: (2000)

Identifying pathological biomarkers: histochemistry still ranks high in the omics era
by: C. Pellicciari, et al.
Published: (2011-12-01)

Light microscope observation of circulating human lymphocytes cultured in vitro
by: Naila Francis Paulo de Oliveira, et al.
Published: (2010-10-01)

Mitochondrial Features of Mouse Myoblasts Are Finely Tuned by Low Doses of Ozone: The Evidence In Vitro
by: Chiara Rita Inguscio, et al.
Published: (2023-05-01)

Transmission Electron Microscopy as a Powerful Tool to Investigate the Interaction of Nanoparticles with Subcellular Structures
by: Manuela Malatesta
Published: (2021-11-01)

Tracking neuronal motility in live murine retinal explants
by: Nozie D. Aghaizu, et al.
Published: (2021-12-01)

Techniques in microscopy for biomedical applications /
by: Dokland, Terje
Published: (2006)

Electron beam specimen interactions /
by: 273613 Dickson, Melvyn
Published: (2001)

Acoustic scanning probe microscopy /
by: Marinello, Francesco, et al.
Published: (2012)

Multispectral intravital microscopy for simultaneous bright-field and fluorescence imaging of the microvasculature
by: Barry G. H. Janssen, et al.
Published: (2021-07-01)

Exploring Active Peptides with Antimicrobial Activity In Planta against <i>Xylella fastidiosa</i>
by: Kaoutar El Handi, et al.
Published: (2022-11-01)

Morphological and anatomical insights into de novo shoot organogenesis of in vitro ‘Delite’ rabbiteye blueberries
by: Carolina Schuchovski, et al.
Published: (2020-11-01)

Nonlinear optical microscopy for skin in vivo: Basics, development and applications
by: Jianhua Zhao, et al.
Published: (2023-01-01)

Examination of explants by electron microscopy and correlations with the biomechanical score of prosthetic restorations with implant support
by: Michael Vitzu, et al.
Published: (2021-03-01)

Advances in optical and electron microscopy /
by: Mulvey, T., et al.
Published: (1989)