ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1–BLM Interaction

ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1–BLM Interaction

DNA damage is the major cause of senescence and apoptosis; however, the manner by which DNA-damaged cells become senescent remains unclear. We demonstrate that DNA damage leads to a greater level of senescence rather than apoptosis in DBC1-deficient cells. In addition, we show that BLM becomes degra...

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Bibliographic Details
Main Authors: Feng Cui, Xueying Han, Xiaoqian Zhang, Siqi Wang, Na Liang, Qing Tan, Wuga Sha, Jun Li
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
senescence
DBC1
BLM
fibrosis
ML216
Online Access:https://www.mdpi.com/2073-4409/12/1/145

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