Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases
Abstract Introduction The purpose of this study was to investigate the relation between preoperative cachexia index (CXI) and long‐term outcomes in patients with colorectal liver metastases (CRLM) after hepatic resection. Method In all,118 patients who underwent hepatic resection for CRLM were analy...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Annals of Gastroenterological Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ags3.12578 |
| _version_ | 1811248434040012800 |
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| author | Yoshiaki Tanji Kenei Furukawa Koichiro Haruki Tomohiko Taniai Shinji Onda Masashi Tsunematsu Yoshihiro Shirai Mitsuru Yanagaki Yosuke Igarashi Toru Ikegami |
| author_facet | Yoshiaki Tanji Kenei Furukawa Koichiro Haruki Tomohiko Taniai Shinji Onda Masashi Tsunematsu Yoshihiro Shirai Mitsuru Yanagaki Yosuke Igarashi Toru Ikegami |
| author_sort | Yoshiaki Tanji |
| collection | DOAJ |
| description | Abstract Introduction The purpose of this study was to investigate the relation between preoperative cachexia index (CXI) and long‐term outcomes in patients with colorectal liver metastases (CRLM) after hepatic resection. Method In all,118 patients who underwent hepatic resection for CRLM were analyzed retrospectively. The relationship between CXI and the long‐term outcomes in patients after hepatic resection was investigated. CXI was calculated based on preoperative skeletal muscle index, serum albumin level, and neutrophil–lymphocyte ratio. Results The multivariate analysis showed that extrahepatic lesion (hazard ratio [HR] 2.86, 95% confidence interval [CI] 1.48–5.53, P < .01) and high CXI (HR 0.44, 95% CI 0.20–0.98, P = .04) were independent and significant predictors of disease‐free survival. Moreover, extrahepatic lesion (HR 2.32, 95% CI 1.03–5.22, P = .04), high CXI (HR 0.17, 95% CI 0.05–0.57, P < .01), and curability R 1 or 2 (HR 3.29, 95% CI 1.23–8.78, P = .02) were independent and significant predictors of overall survival. Conclusion CXI is a useful prognostic factor for disease‐free survival and overall survival after hepatic resection in CRLM patients. |
| first_indexed | 2024-04-12T15:27:56Z |
| format | Article |
| id | doaj.art-445dd1b0461246a1b4c00e6dcdcf51eb |
| institution | Directory Open Access Journal |
| issn | 2475-0328 |
| language | English |
| last_indexed | 2024-04-12T15:27:56Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj.art-445dd1b0461246a1b4c00e6dcdcf51eb2022-12-22T03:27:12ZengWileyAnnals of Gastroenterological Surgery2475-03282022-11-016680481210.1002/ags3.12578Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastasesYoshiaki Tanji0Kenei Furukawa1Koichiro Haruki2Tomohiko Taniai3Shinji Onda4Masashi Tsunematsu5Yoshihiro Shirai6Mitsuru Yanagaki7Yosuke Igarashi8Toru Ikegami9Division of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery The Jikei University School of Medicine Tokyo JapanAbstract Introduction The purpose of this study was to investigate the relation between preoperative cachexia index (CXI) and long‐term outcomes in patients with colorectal liver metastases (CRLM) after hepatic resection. Method In all,118 patients who underwent hepatic resection for CRLM were analyzed retrospectively. The relationship between CXI and the long‐term outcomes in patients after hepatic resection was investigated. CXI was calculated based on preoperative skeletal muscle index, serum albumin level, and neutrophil–lymphocyte ratio. Results The multivariate analysis showed that extrahepatic lesion (hazard ratio [HR] 2.86, 95% confidence interval [CI] 1.48–5.53, P < .01) and high CXI (HR 0.44, 95% CI 0.20–0.98, P = .04) were independent and significant predictors of disease‐free survival. Moreover, extrahepatic lesion (HR 2.32, 95% CI 1.03–5.22, P = .04), high CXI (HR 0.17, 95% CI 0.05–0.57, P < .01), and curability R 1 or 2 (HR 3.29, 95% CI 1.23–8.78, P = .02) were independent and significant predictors of overall survival. Conclusion CXI is a useful prognostic factor for disease‐free survival and overall survival after hepatic resection in CRLM patients.https://doi.org/10.1002/ags3.12578cachexiacolorectal liver metastasesliver resection |
| spellingShingle | Yoshiaki Tanji Kenei Furukawa Koichiro Haruki Tomohiko Taniai Shinji Onda Masashi Tsunematsu Yoshihiro Shirai Mitsuru Yanagaki Yosuke Igarashi Toru Ikegami Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases Annals of Gastroenterological Surgery cachexia colorectal liver metastases liver resection |
| title | Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases |
| title_full | Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases |
| title_fullStr | Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases |
| title_full_unstemmed | Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases |
| title_short | Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases |
| title_sort | significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases |
| topic | cachexia colorectal liver metastases liver resection |
| url | https://doi.org/10.1002/ags3.12578 |
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