Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil
To assess the prevalence of primary resistance of human immunodeficiency virus type 1 (HIV-1) to antiretrovirals, 84 patients chronically infected with HIV without prior antiretroviral treatment from Northeast Brazil were studied. Genotyping was performed using the ViroSeqTM Genotyping System. Thimi...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2006-12-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000800004 |
| _version_ | 1797704723357237248 |
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| author | Luzidalva Barbosa de Medeiros Heloísa Ramos Lacerda Ana Maria Salustiano Cavalcanti Maria de Fátima Pessoa Militão de Albuquerque |
| author_facet | Luzidalva Barbosa de Medeiros Heloísa Ramos Lacerda Ana Maria Salustiano Cavalcanti Maria de Fátima Pessoa Militão de Albuquerque |
| author_sort | Luzidalva Barbosa de Medeiros |
| collection | DOAJ |
| description | To assess the prevalence of primary resistance of human immunodeficiency virus type 1 (HIV-1) to antiretrovirals, 84 patients chronically infected with HIV without prior antiretroviral treatment from Northeast Brazil were studied. Genotyping was performed using the ViroSeqTM Genotyping System. Thimidine analog mutations occurred in 3 (3.6%) patients. Accessory mutations related to NRTI occurred in 6 (7.1%) and related to PI in 67 (79.8%). Subtypes B (72.6%), F (22.6%), B/F 3 (3.6%), and C (1.2%) were detected. A low prevalence of major mutations related to NRTI in patients chronically infected by HIV was observed. |
| first_indexed | 2024-03-12T05:25:39Z |
| format | Article |
| id | doaj.art-445eeaa6f732437ba9e264d36457b393 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T05:25:39Z |
| publishDate | 2006-12-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-445eeaa6f732437ba9e264d36457b3932023-09-03T07:24:43ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602006-12-01101884584910.1590/S0074-02762006000800004Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, BrazilLuzidalva Barbosa de MedeirosHeloísa Ramos LacerdaAna Maria Salustiano CavalcantiMaria de Fátima Pessoa Militão de AlbuquerqueTo assess the prevalence of primary resistance of human immunodeficiency virus type 1 (HIV-1) to antiretrovirals, 84 patients chronically infected with HIV without prior antiretroviral treatment from Northeast Brazil were studied. Genotyping was performed using the ViroSeqTM Genotyping System. Thimidine analog mutations occurred in 3 (3.6%) patients. Accessory mutations related to NRTI occurred in 6 (7.1%) and related to PI in 67 (79.8%). Subtypes B (72.6%), F (22.6%), B/F 3 (3.6%), and C (1.2%) were detected. A low prevalence of major mutations related to NRTI in patients chronically infected by HIV was observed.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000800004human imunodeficiency virus type 1primary resistance to drugsgenotypingsubtypesBrazil |
| spellingShingle | Luzidalva Barbosa de Medeiros Heloísa Ramos Lacerda Ana Maria Salustiano Cavalcanti Maria de Fátima Pessoa Militão de Albuquerque Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil Memorias do Instituto Oswaldo Cruz human imunodeficiency virus type 1 primary resistance to drugs genotyping subtypes Brazil |
| title | Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil |
| title_full | Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil |
| title_fullStr | Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil |
| title_full_unstemmed | Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil |
| title_short | Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil |
| title_sort | primary resistance of human immunodeficiency virus type 1 in a reference center in recife pernambuco brazil |
| topic | human imunodeficiency virus type 1 primary resistance to drugs genotyping subtypes Brazil |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000800004 |
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