Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma
The mesothelium supports homeostasis and regeneration, yet its development origins remain unclear. Here, the authors uncovered the earliest mesothelium progenitor cells in zebrafish, linking Hand2 gene function to mesothelium formation and its re-activation to mesothelioma tumors.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29311-7 |
| _version_ | 1818354586136608768 |
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| author | Karin D. Prummel Helena L. Crowell Susan Nieuwenhuize Eline C. Brombacher Stephan Daetwyler Charlotte Soneson Jelena Kresoja-Rakic Agnese Kocere Manuel Ronner Alexander Ernst Zahra Labbaf David E. Clouthier Anthony B. Firulli Héctor Sánchez-Iranzo Sundar R. Naganathan Rebecca O’Rourke Erez Raz Nadia Mercader Alexa Burger Emanuela Felley-Bosco Jan Huisken Mark D. Robinson Christian Mosimann |
| author_facet | Karin D. Prummel Helena L. Crowell Susan Nieuwenhuize Eline C. Brombacher Stephan Daetwyler Charlotte Soneson Jelena Kresoja-Rakic Agnese Kocere Manuel Ronner Alexander Ernst Zahra Labbaf David E. Clouthier Anthony B. Firulli Héctor Sánchez-Iranzo Sundar R. Naganathan Rebecca O’Rourke Erez Raz Nadia Mercader Alexa Burger Emanuela Felley-Bosco Jan Huisken Mark D. Robinson Christian Mosimann |
| author_sort | Karin D. Prummel |
| collection | DOAJ |
| description | The mesothelium supports homeostasis and regeneration, yet its development origins remain unclear. Here, the authors uncovered the earliest mesothelium progenitor cells in zebrafish, linking Hand2 gene function to mesothelium formation and its re-activation to mesothelioma tumors. |
| first_indexed | 2024-12-13T19:27:46Z |
| format | Article |
| id | doaj.art-445f40166b9345a1905f77ae35cd17f3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T19:27:46Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-445f40166b9345a1905f77ae35cd17f32022-12-21T23:34:00ZengNature PortfolioNature Communications2041-17232022-03-0113112110.1038/s41467-022-29311-7Hand2 delineates mesothelium progenitors and is reactivated in mesotheliomaKarin D. Prummel0Helena L. Crowell1Susan Nieuwenhuize2Eline C. Brombacher3Stephan Daetwyler4Charlotte Soneson5Jelena Kresoja-Rakic6Agnese Kocere7Manuel Ronner8Alexander Ernst9Zahra Labbaf10David E. Clouthier11Anthony B. Firulli12Héctor Sánchez-Iranzo13Sundar R. Naganathan14Rebecca O’Rourke15Erez Raz16Nadia Mercader17Alexa Burger18Emanuela Felley-Bosco19Jan Huisken20Mark D. Robinson21Christian Mosimann22Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical CampusDepartment of Molecular Life Sciences, University of ZurichDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical CampusDepartment of Molecular Life Sciences, University of ZurichMax Planck Institute of Molecular Cell Biology and GeneticsDepartment of Molecular Life Sciences, University of ZurichDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical CampusDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical CampusLaboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital ZurichInstitute of Anatomy, University of BernInstitute for Cell Biology, ZMBEDepartment of Craniofacial Biology, University of Colorado Anschutz Medical CampusHerman B Wells Center for Pediatric Research, Departments of Pediatrics, Anatomy and Medical and Molecular Genetics, Indiana Medical SchoolCentro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII)Institute of Bioengineering, Ecole Polytechnique Federale de LausanneDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical CampusInstitute for Cell Biology, ZMBEInstitute of Anatomy, University of BernDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical CampusLaboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital ZurichMax Planck Institute of Molecular Cell Biology and GeneticsDepartment of Molecular Life Sciences, University of ZurichDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical CampusThe mesothelium supports homeostasis and regeneration, yet its development origins remain unclear. Here, the authors uncovered the earliest mesothelium progenitor cells in zebrafish, linking Hand2 gene function to mesothelium formation and its re-activation to mesothelioma tumors.https://doi.org/10.1038/s41467-022-29311-7 |
| spellingShingle | Karin D. Prummel Helena L. Crowell Susan Nieuwenhuize Eline C. Brombacher Stephan Daetwyler Charlotte Soneson Jelena Kresoja-Rakic Agnese Kocere Manuel Ronner Alexander Ernst Zahra Labbaf David E. Clouthier Anthony B. Firulli Héctor Sánchez-Iranzo Sundar R. Naganathan Rebecca O’Rourke Erez Raz Nadia Mercader Alexa Burger Emanuela Felley-Bosco Jan Huisken Mark D. Robinson Christian Mosimann Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma Nature Communications |
| title | Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma |
| title_full | Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma |
| title_fullStr | Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma |
| title_full_unstemmed | Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma |
| title_short | Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma |
| title_sort | hand2 delineates mesothelium progenitors and is reactivated in mesothelioma |
| url | https://doi.org/10.1038/s41467-022-29311-7 |
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