Activation of the cAMP Pathway in Ustilago maydis Reduces Fungal Proliferation and Teliospore Formation in Plant Tumors
In the corn smut fungus Ustilago maydis, mating of two haploid sporidia is a prerequisite for subsequent colonization of the host. Cyclic AMP (cAMP) and pheromone signals have been implicated in this developmental program. The cAMP pathway is also needed for subsequent fungal development in planta,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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The American Phytopathological Society
2000-10-01
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| Series: | Molecular Plant-Microbe Interactions |
| Online Access: | https://apsjournals.apsnet.org/doi/10.1094/MPMI.2000.13.10.1034 |
| _version_ | 1811277675294097408 |
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| author | Julia Krüger Gabriel Loubradou Gerhard Wanner Erika Regenfelder Michael Feldbrügge Regine Kahmann |
| author_facet | Julia Krüger Gabriel Loubradou Gerhard Wanner Erika Regenfelder Michael Feldbrügge Regine Kahmann |
| author_sort | Julia Krüger |
| collection | DOAJ |
| description | In the corn smut fungus Ustilago maydis, mating of two haploid sporidia is a prerequisite for subsequent colonization of the host. Cyclic AMP (cAMP) and pheromone signals have been implicated in this developmental program. The cAMP pathway is also needed for subsequent fungal development in planta, as null mutants in any component of the pathway fail to form tumors. Here we show that moderate activation of the pathway conferred either by mutation in the Gα subunit or by mutation in the regulatory subunit of the protein kinase A influences tumor morphology. In the resulting tumors, the amount of fungal material is drastically reduced and fungal development is arrested at the stage of sporogenic hyphae. We conclude that tight regulation of the cAMP pathway is crucial for fungal development within the plant but does not interfere with the tumor induction process. |
| first_indexed | 2024-04-13T00:21:01Z |
| format | Article |
| id | doaj.art-445f8c5fc21543aab2012cdb96a95567 |
| institution | Directory Open Access Journal |
| issn | 0894-0282 1943-7706 |
| language | English |
| last_indexed | 2024-04-13T00:21:01Z |
| publishDate | 2000-10-01 |
| publisher | The American Phytopathological Society |
| record_format | Article |
| series | Molecular Plant-Microbe Interactions |
| spelling | doaj.art-445f8c5fc21543aab2012cdb96a955672022-12-22T03:10:45ZengThe American Phytopathological SocietyMolecular Plant-Microbe Interactions0894-02821943-77062000-10-0113101034104010.1094/MPMI.2000.13.10.1034Activation of the cAMP Pathway in Ustilago maydis Reduces Fungal Proliferation and Teliospore Formation in Plant TumorsJulia KrügerGabriel LoubradouGerhard WannerErika RegenfelderMichael FeldbrüggeRegine KahmannIn the corn smut fungus Ustilago maydis, mating of two haploid sporidia is a prerequisite for subsequent colonization of the host. Cyclic AMP (cAMP) and pheromone signals have been implicated in this developmental program. The cAMP pathway is also needed for subsequent fungal development in planta, as null mutants in any component of the pathway fail to form tumors. Here we show that moderate activation of the pathway conferred either by mutation in the Gα subunit or by mutation in the regulatory subunit of the protein kinase A influences tumor morphology. In the resulting tumors, the amount of fungal material is drastically reduced and fungal development is arrested at the stage of sporogenic hyphae. We conclude that tight regulation of the cAMP pathway is crucial for fungal development within the plant but does not interfere with the tumor induction process.https://apsjournals.apsnet.org/doi/10.1094/MPMI.2000.13.10.1034 |
| spellingShingle | Julia Krüger Gabriel Loubradou Gerhard Wanner Erika Regenfelder Michael Feldbrügge Regine Kahmann Activation of the cAMP Pathway in Ustilago maydis Reduces Fungal Proliferation and Teliospore Formation in Plant Tumors Molecular Plant-Microbe Interactions |
| title | Activation of the cAMP Pathway in Ustilago maydis Reduces Fungal Proliferation and Teliospore Formation in Plant Tumors |
| title_full | Activation of the cAMP Pathway in Ustilago maydis Reduces Fungal Proliferation and Teliospore Formation in Plant Tumors |
| title_fullStr | Activation of the cAMP Pathway in Ustilago maydis Reduces Fungal Proliferation and Teliospore Formation in Plant Tumors |
| title_full_unstemmed | Activation of the cAMP Pathway in Ustilago maydis Reduces Fungal Proliferation and Teliospore Formation in Plant Tumors |
| title_short | Activation of the cAMP Pathway in Ustilago maydis Reduces Fungal Proliferation and Teliospore Formation in Plant Tumors |
| title_sort | activation of the camp pathway in ustilago maydis reduces fungal proliferation and teliospore formation in plant tumors |
| url | https://apsjournals.apsnet.org/doi/10.1094/MPMI.2000.13.10.1034 |
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