Effect of chronic ethanol exposure on rat ventilatory responses to hypoxia and hypercapnia
OBJECTIVE: The effect of chronic ethanol exposure on chemoreflexes has not been extensively studied in experimental animals. Therefore, this study tested the hypothesis that known ethanol-induced autonomic, neuroendocrine and cardiovascular changes coincide with increased chemoreflex sensitivity, as...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2014-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000500360&lng=en&tlng=en |
| _version_ | 1811316881586388992 |
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| author | João Paulo J. Sabino Andreia Lopes da Silva Leonardo B. Resstel Jose Antunes-Rodrigues Mogens L. Glass Luiz G.S. Branco |
| author_facet | João Paulo J. Sabino Andreia Lopes da Silva Leonardo B. Resstel Jose Antunes-Rodrigues Mogens L. Glass Luiz G.S. Branco |
| author_sort | João Paulo J. Sabino |
| collection | DOAJ |
| description | OBJECTIVE: The effect of chronic ethanol exposure on chemoreflexes has not been extensively studied in experimental animals. Therefore, this study tested the hypothesis that known ethanol-induced autonomic, neuroendocrine and cardiovascular changes coincide with increased chemoreflex sensitivity, as indicated by increased ventilatory responses to hypoxia and hypercapnia. METHODS: Male Wistar rats were subjected to increasing ethanol concentrations in their drinking water (first week: 5% v/v, second week: 10% v/v, third and fourth weeks: 20% v/v). At the end of each week of ethanol exposure, ventilatory parameters were measured under basal conditions and in response to hypoxia (evaluation of peripheral chemoreflex sensitivity) and hypercapnia (evaluation of central chemoreflex sensitivity). RESULTS: Decreased respiratory frequency was observed in rats exposed to ethanol from the first until the fourth week, whereas minute ventilation remained unchanged. Moreover, we observed an increased tidal volume in the second through the fourth week of exposure. The minute ventilation responses to hypoxia were attenuated in the first through the third week but remained unchanged during the last week. The respiratory frequency responses to hypoxia in ethanol-exposed rats were attenuated in the second through the third week but remained unchanged in the first and fourth weeks. There was no significant change in tidal volume responses to hypoxia. With regard to hypercapnic responses, no significant changes in ventilatory parameters were observed. CONCLUSIONS: Our data are consistent with the notion that chronic ethanol exposure does not increase peripheral or central chemoreflex sensitivity. |
| first_indexed | 2024-04-13T11:57:01Z |
| format | Article |
| id | doaj.art-44615032f8bb4fc4980916d5f1869a11 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T11:57:01Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-44615032f8bb4fc4980916d5f1869a112022-12-22T02:47:54ZengElsevier EspañaClinics1980-53222014-01-0169536036610.6061/clinics/2014(05)11S1807-59322014000500360Effect of chronic ethanol exposure on rat ventilatory responses to hypoxia and hypercapniaJoão Paulo J. SabinoAndreia Lopes da SilvaLeonardo B. ResstelJose Antunes-RodriguesMogens L. GlassLuiz G.S. BrancoOBJECTIVE: The effect of chronic ethanol exposure on chemoreflexes has not been extensively studied in experimental animals. Therefore, this study tested the hypothesis that known ethanol-induced autonomic, neuroendocrine and cardiovascular changes coincide with increased chemoreflex sensitivity, as indicated by increased ventilatory responses to hypoxia and hypercapnia. METHODS: Male Wistar rats were subjected to increasing ethanol concentrations in their drinking water (first week: 5% v/v, second week: 10% v/v, third and fourth weeks: 20% v/v). At the end of each week of ethanol exposure, ventilatory parameters were measured under basal conditions and in response to hypoxia (evaluation of peripheral chemoreflex sensitivity) and hypercapnia (evaluation of central chemoreflex sensitivity). RESULTS: Decreased respiratory frequency was observed in rats exposed to ethanol from the first until the fourth week, whereas minute ventilation remained unchanged. Moreover, we observed an increased tidal volume in the second through the fourth week of exposure. The minute ventilation responses to hypoxia were attenuated in the first through the third week but remained unchanged during the last week. The respiratory frequency responses to hypoxia in ethanol-exposed rats were attenuated in the second through the third week but remained unchanged in the first and fourth weeks. There was no significant change in tidal volume responses to hypoxia. With regard to hypercapnic responses, no significant changes in ventilatory parameters were observed. CONCLUSIONS: Our data are consistent with the notion that chronic ethanol exposure does not increase peripheral or central chemoreflex sensitivity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000500360&lng=en&tlng=enEthanolChemoreflexHypercapniaHypoxia |
| spellingShingle | João Paulo J. Sabino Andreia Lopes da Silva Leonardo B. Resstel Jose Antunes-Rodrigues Mogens L. Glass Luiz G.S. Branco Effect of chronic ethanol exposure on rat ventilatory responses to hypoxia and hypercapnia Clinics Ethanol Chemoreflex Hypercapnia Hypoxia |
| title | Effect of chronic ethanol exposure on rat ventilatory responses to hypoxia and hypercapnia |
| title_full | Effect of chronic ethanol exposure on rat ventilatory responses to hypoxia and hypercapnia |
| title_fullStr | Effect of chronic ethanol exposure on rat ventilatory responses to hypoxia and hypercapnia |
| title_full_unstemmed | Effect of chronic ethanol exposure on rat ventilatory responses to hypoxia and hypercapnia |
| title_short | Effect of chronic ethanol exposure on rat ventilatory responses to hypoxia and hypercapnia |
| title_sort | effect of chronic ethanol exposure on rat ventilatory responses to hypoxia and hypercapnia |
| topic | Ethanol Chemoreflex Hypercapnia Hypoxia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000500360&lng=en&tlng=en |
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