Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications
Epilepsy is a neurological disorder characterized by high morbidity, high recurrence, and drug resistance. Enhanced signaling through the excitatory neurotransmitter glutamate is intricately associated with epilepsy. Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors activated...
| मुख्य लेखकों: | , , , , , , , , , |
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| स्वरूप: | लेख |
| भाषा: | English |
| प्रकाशित: |
Wolters Kluwer Medknow Publications
2024-01-01
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| श्रृंखला: | Neural Regeneration Research |
| विषय: | |
| ऑनलाइन पहुंच: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=2;spage=360;epage=368;aulast= |
| _version_ | 1827861745862967296 |
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| author | Leyi Huang Wenjie Xiao Yan Wang Juan Li Jiaoe Gong Ewen Tu Lili Long Bo Xiao Xiaoxin Yan Lily Wan |
| author_facet | Leyi Huang Wenjie Xiao Yan Wang Juan Li Jiaoe Gong Ewen Tu Lili Long Bo Xiao Xiaoxin Yan Lily Wan |
| author_sort | Leyi Huang |
| collection | DOAJ |
| description | Epilepsy is a neurological disorder characterized by high morbidity, high recurrence, and drug resistance. Enhanced signaling through the excitatory neurotransmitter glutamate is intricately associated with epilepsy. Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors activated by glutamate and are key regulators of neuronal and synaptic plasticity. Dysregulated mGluR signaling has been associated with various neurological disorders, and numerous studies have shown a close relationship between mGluRs expression/activity and the development of epilepsy. In this review, we first introduce the three groups of mGluRs and their associated signaling pathways. Then, we detail how these receptors influence epilepsy by describing the signaling cascades triggered by their activation and their neuroprotective or detrimental roles in epileptogenesis. In addition, strategies for pharmacological manipulation of these receptors during the treatment of epilepsy in experimental studies is also summarized. We hope that this review will provide a foundation for future studies on the development of mGluR-targeted antiepileptic drugs. |
| first_indexed | 2024-03-12T13:43:55Z |
| format | Article |
| id | doaj.art-4461d288e33e4331a2a5b51c712ddb1f |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-03-12T13:43:55Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-4461d288e33e4331a2a5b51c712ddb1f2023-08-23T09:46:18ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742024-01-0119236036810.4103/1673-5374.379018Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implicationsLeyi HuangWenjie XiaoYan WangJuan LiJiaoe GongEwen TuLili LongBo XiaoXiaoxin YanLily WanEpilepsy is a neurological disorder characterized by high morbidity, high recurrence, and drug resistance. Enhanced signaling through the excitatory neurotransmitter glutamate is intricately associated with epilepsy. Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors activated by glutamate and are key regulators of neuronal and synaptic plasticity. Dysregulated mGluR signaling has been associated with various neurological disorders, and numerous studies have shown a close relationship between mGluRs expression/activity and the development of epilepsy. In this review, we first introduce the three groups of mGluRs and their associated signaling pathways. Then, we detail how these receptors influence epilepsy by describing the signaling cascades triggered by their activation and their neuroprotective or detrimental roles in epileptogenesis. In addition, strategies for pharmacological manipulation of these receptors during the treatment of epilepsy in experimental studies is also summarized. We hope that this review will provide a foundation for future studies on the development of mGluR-targeted antiepileptic drugs.http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=2;spage=360;epage=368;aulast=antiepileptic drugs; epileptogenesis; metabotropic glutamate receptors (mglurs); signal pathways; therapeutic potentials |
| spellingShingle | Leyi Huang Wenjie Xiao Yan Wang Juan Li Jiaoe Gong Ewen Tu Lili Long Bo Xiao Xiaoxin Yan Lily Wan Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications Neural Regeneration Research antiepileptic drugs; epileptogenesis; metabotropic glutamate receptors (mglurs); signal pathways; therapeutic potentials |
| title | Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications |
| title_full | Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications |
| title_fullStr | Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications |
| title_full_unstemmed | Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications |
| title_short | Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications |
| title_sort | metabotropic glutamate receptors mglurs in epileptogenesis an update on abnormal mglurs signaling and its therapeutic implications |
| topic | antiepileptic drugs; epileptogenesis; metabotropic glutamate receptors (mglurs); signal pathways; therapeutic potentials |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=2;spage=360;epage=368;aulast= |
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