Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications

Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications

Epilepsy is a neurological disorder characterized by high morbidity, high recurrence, and drug resistance. Enhanced signaling through the excitatory neurotransmitter glutamate is intricately associated with epilepsy. Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors activated...

ver descrição completa

Detalhes bibliográficos
Principais autores:	Leyi Huang, Wenjie Xiao, Yan Wang, Juan Li, Jiaoe Gong, Ewen Tu, Lili Long, Bo Xiao, Xiaoxin Yan, Lily Wan
Formato:	Artigo
Idioma:	English
Publicado em:	Wolters Kluwer Medknow Publications 2024-01-01
coleção:	Neural Regeneration Research
Assuntos:	antiepileptic drugs; epileptogenesis; metabotropic glutamate receptors (mglurs); signal pathways; therapeutic potentials
Acesso em linha:	http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=2;spage=360;epage=368;aulast=

Registros relacionados

Anti-mGluR1 encephalitis: Case illustration and systematic review
por: Osama Khojah, et al.
Publicado em: (2023-04-01)

“Niclosamide: A potential antipruritic agent by modulating serotonin pathway through metabotropic glutamate receptors (mGluRs)”
por: Zahra Ebrahim Soltani, et al.
Publicado em: (2024-06-01)

Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception
por: Crock Lara W, et al.
Publicado em: (2012-03-01)

Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem
por: Nupur Goel, et al.
Publicado em: (2020-11-01)

Group I mGluRs in Therapy and Diagnosis of Parkinson’s Disease: Focus on mGluR5 Subtype
por: Shofiul Azam, et al.
Publicado em: (2022-04-01)

Group I metabotropic glutamate receptors (mGluR1/5) and neurodegenerative diseases
por: Elena I. Solntseva, et al.
Publicado em: (2019-12-01)

Metabotropic glutamate receptor 5 (mGluR5) regulates white adipocyte browning
por: LUO Xie, ZENG Li, YUAN Lei
Publicado em: (2021-01-01)

Can Metabotropic Glutamate Receptor 7 (mGluR 7) be a Novel Target for Analgesia?
por: Shivaprakash G, et al.
Publicado em: (2014-09-01)

Encephalitis Associated to Metabotropic Glutamate Receptor 5 (mGluR5) Antibodies in Cerebrospinal Fluid
por: Carlos Guevara, et al.
Publicado em: (2018-11-01)

Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy
por: J. Pitsch, et al.
Publicado em: (2007-06-01)

mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning
por: Maria Harbers, et al.
Publicado em: (2022-06-01)

Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer’s Mouse Phenotypes
por: Laura T. Haas, et al.
Publicado em: (2017-07-01)

mGluR5 in amygdala modulates fear memory generalization
por: Shou-Min Xuan, et al.
Publicado em: (2023-02-01)

Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRs
por: Sanderson Thomas M, et al.
Publicado em: (2011-07-01)

Characterization of Umami Dry-Cured Ham-Derived Dipeptide Interaction with Metabotropic Glutamate Receptor (mGluR) by Molecular Docking Simulation
por: Alejandro Heres, et al.
Publicado em: (2021-09-01)

Expression of group II and III mGluRs in the carotid body and its role in the carotid chemoreceptor response to acute hypoxia
por: Chenlu Zhao, et al.
Publicado em: (2022-09-01)

NMDA and mGluR1 receptor subtypes as major players affecting depotentiation in the hippocampal CA1-region
por: Amira Latif-Hernandez
Publicado em: (2014-03-01)

Positive Allosteric Modulators of Type 5 Metabotropic Glutamate Receptors (mGluR5) and Their Therapeutic Potential for the Treatment of CNS Disorders
por: Richard M. Cleva, et al.
Publicado em: (2011-03-01)

PET imaging of mGluR5 in Alzheimer’s disease
por: Adam P. Mecca, et al.
Publicado em: (2020-01-01)

Store-Operated Calcium Entry Is Required for mGluR-Dependent Long Term Depression in Cortical Neurons
por: Paloma González-Sánchez, et al.
Publicado em: (2017-12-01)

Reduced mGluR5 Activity Modulates Mitochondrial Function
por: Miguel A. Gonzalez-Lozano, et al.
Publicado em: (2021-06-01)

mGluR-dependent synaptic plasticity in drug-seeking.
por: Camilla eBellone, et al.
Publicado em: (2012-08-01)

Activation of a Temporal Memory in Purkinje Cells by the mGluR7 Receptor
por: Fredrik Johansson, et al.
Publicado em: (2015-12-01)

Long-Term Depression of Striatal DA Release Induced by mGluRs via Sustained Hyperactivity of Local Cholinergic Interneurons
por: Nicola B. Mercuri, et al.
Publicado em: (2021-12-01)

Therapeutic potential of mGluR5 targeting in Alzheimer's disease
por: Anil eKumar, et al.
Publicado em: (2015-06-01)

Microtransplantation of Postmortem Native Synaptic mGluRs Receptors into <i>Xenopus</i> Oocytes for Their Functional Analysis
por: Brice Miller, et al.
Publicado em: (2022-09-01)

Separate ionotropic and metabotropic glutamate receptor functions in depotentiation versus LTP: A distinct role for group1 mGluR subtypes and NMDARs
por: Amira Latif-Hernandez, et al.
Publicado em: (2016-11-01)

Isolation of rat hepatocytes for pharmacological studies on metabotropic glutamate receptor (mGluR) subtype 5: a comparison between collagenase I versus collagenase IV
por: Clarissa Berardo, et al.
Publicado em: (2020-03-01)

Development of [18F]-PSS223 as a PET Tracer for Imaging of Metabotropic Glutamate Receptor Subtype 5 (mGluR5)
por: Selena Milicevic Sephton, et al.
Publicado em: (2012-04-01)

Translational concepts of mGluR5 in synaptic diseases of the brain
por: Thomas M Piers, et al.
Publicado em: (2012-11-01)

Selective Recruitment of Presynaptic and Postsynaptic Forms of mGluR-LTD
por: Thomas M. Sanderson, et al.
Publicado em: (2022-05-01)

Hodgkin Lymphoma Cell Lines and Tissues Express mGluR5: A Potential Link to Ophelia Syndrome and Paraneoplastic Neurological Disease
por: Sofia Schnell, et al.
Publicado em: (2023-02-01)

mGluR-dependent plasticity in rodent models of Alzheimer’s disease
por: Gonzalo Valdivia, et al.
Publicado em: (2023-03-01)

Analysis of the Gut Microbiota and Inflammatory Factors in mGluR5-Knockout Mice
por: Guohong Cai, et al.
Publicado em: (2020-04-01)

Effects of post-training administration of LY341495, as an mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet
por: Heresh Moridi, et al.
Publicado em: (2020-12-01)

A molecular perspective on mGluR5 regulation in the antidepressant effect of ketamine
por: Ola Sobhy A. Elmeseiny, et al.
Publicado em: (2024-02-01)

Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer’s disease: A [18F]PSS232 PET/MRI study
por: Jie Wang, et al.
Publicado em: (2024-01-01)

Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD Induction
por: Hiroki Yasuda, et al.
Publicado em: (2018-10-01)

Overexpression of mGluR7 in the Prefrontal Cortex Attenuates Autistic Behaviors in Mice
por: Xiaona Wang, et al.
Publicado em: (2021-07-01)

Correlation of Receptor Occupancy of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Mouse Brain With In vivo Activity of Allosteric mGluR1 Antagonists
por: Gentaroh Suzuki, et al.
Publicado em: (2009-01-01)