Pathologic Cellular Events in Smoking-Related Pancreatitis
Pancreatitis, a debilitating inflammatory disorder, results from pancreatic injury. Alcohol abuse is the foremost cause, although cigarette smoking has recently surfaced as a distinct risk factor. The mechanisms by which cigarette smoke and its toxins initiate pathological cellular events leading to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-04-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/7/2/723 |
| _version_ | 1797762647838425088 |
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| author | Edwin Thrower |
| author_facet | Edwin Thrower |
| author_sort | Edwin Thrower |
| collection | DOAJ |
| description | Pancreatitis, a debilitating inflammatory disorder, results from pancreatic injury. Alcohol abuse is the foremost cause, although cigarette smoking has recently surfaced as a distinct risk factor. The mechanisms by which cigarette smoke and its toxins initiate pathological cellular events leading to pancreatitis, have not been clearly defined. Although cigarette smoke is composed of more than 4000 compounds, it is mainly nicotine and the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which have been extensively studied with respect to pancreatic diseases. This review summarizes these research findings and highlights cellular pathways which may be of relevance in initiation and progression of smoking-related pancreatitis. |
| first_indexed | 2024-03-12T19:30:26Z |
| format | Article |
| id | doaj.art-4461dcbc8c224edc95488e52fe5177d3 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:30:26Z |
| publishDate | 2015-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4461dcbc8c224edc95488e52fe5177d32023-08-02T04:34:05ZengMDPI AGCancers2072-66942015-04-017272373510.3390/cancers7020723cancers7020723Pathologic Cellular Events in Smoking-Related PancreatitisEdwin Thrower0Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT 06520, USAPancreatitis, a debilitating inflammatory disorder, results from pancreatic injury. Alcohol abuse is the foremost cause, although cigarette smoking has recently surfaced as a distinct risk factor. The mechanisms by which cigarette smoke and its toxins initiate pathological cellular events leading to pancreatitis, have not been clearly defined. Although cigarette smoke is composed of more than 4000 compounds, it is mainly nicotine and the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which have been extensively studied with respect to pancreatic diseases. This review summarizes these research findings and highlights cellular pathways which may be of relevance in initiation and progression of smoking-related pancreatitis.http://www.mdpi.com/2072-6694/7/2/723pancreatitissmokingnicotine4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)nicotinic acetylcholine receptors (nAChRs)inflammationbioactivationβ-adrenergic receptors |
| spellingShingle | Edwin Thrower Pathologic Cellular Events in Smoking-Related Pancreatitis Cancers pancreatitis smoking nicotine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) nicotinic acetylcholine receptors (nAChRs) inflammation bioactivation β-adrenergic receptors |
| title | Pathologic Cellular Events in Smoking-Related Pancreatitis |
| title_full | Pathologic Cellular Events in Smoking-Related Pancreatitis |
| title_fullStr | Pathologic Cellular Events in Smoking-Related Pancreatitis |
| title_full_unstemmed | Pathologic Cellular Events in Smoking-Related Pancreatitis |
| title_short | Pathologic Cellular Events in Smoking-Related Pancreatitis |
| title_sort | pathologic cellular events in smoking related pancreatitis |
| topic | pancreatitis smoking nicotine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) nicotinic acetylcholine receptors (nAChRs) inflammation bioactivation β-adrenergic receptors |
| url | http://www.mdpi.com/2072-6694/7/2/723 |
| work_keys_str_mv | AT edwinthrower pathologiccellulareventsinsmokingrelatedpancreatitis |