Causal relationship between endometriosis with infertility and ankylosing spondylitis
Abstract Retrospective studies have identified an increased risk of ankylosing spondylitis (AS) in endometriosis patients. The purpose of this study was to investigate the causal relationship between clinical phenotypes of endometriosis and AS using mendelian randomized analysis (MR). MR was perform...
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| Format: | Article |
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-40647-y |
| _version_ | 1797452773145444352 |
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| author | Jian-xiong Wang Yue Shen Xi-le Wang Lin-li Ma Sheng-qian Xu |
| author_facet | Jian-xiong Wang Yue Shen Xi-le Wang Lin-li Ma Sheng-qian Xu |
| author_sort | Jian-xiong Wang |
| collection | DOAJ |
| description | Abstract Retrospective studies have identified an increased risk of ankylosing spondylitis (AS) in endometriosis patients. The purpose of this study was to investigate the causal relationship between clinical phenotypes of endometriosis and AS using mendelian randomized analysis (MR). MR was performed using data from genome-wide association studies (GWASs). Heterogeneity, pleiotropy and sensitivity analyses were performed to evaluate the robustness of the results by MR Egger and inverse variance weighted (IVW), leave-one-out analysis. IVW, IVW-MRE (inverse variance weighted multiplicative random effects), weighted median and MR Egger were used to explore the relationship between endometriosis and AS. The IVW analysis showed a causal relationship between infertile endometriosis and AS (OR = 0.8334, P = 0.02191), and the same result was observed with IVW-MRE (OR = 0.8334, P = 0.0007933). However, further stratified analysis showed that no matter which statistical method was used, ovarian endometriosis (IVW: OR = 0.1662, P = 0.4986; IVW-MRE: OR = 0.1662, P = 0.4986; MR Egger: OR = − 0.9577, P = 0.2798; Weighted median: OR = 0.2628, P = 0.3452), pelvic peritoneum endometriosis (IVW: OR = 0.4363, P = 0.225; IVW-MRE: OR = 0.4363, P = 0.225, MR Egger: OR = 4.159, P = 0.1705; Weighted median: OR = 0.4112, P = 0.2714), rectovaginal endometriosis (IVW: OR = 0.1365, P = 0.805; IVW-MRE: OR = 0.1365, P = 0.805) there was no causal relationship between endometriosis and AS. This study suggested that patients with infertility endometriosis are at increased risk for AS. This study supports clinicians to pay more attention to the occurrence of AS in endometriosis patients with infertility. |
| first_indexed | 2024-03-09T15:13:31Z |
| format | Article |
| id | doaj.art-446453aecc444800b6cfd7991e199b33 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:13:31Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-446453aecc444800b6cfd7991e199b332023-11-26T13:14:39ZengNature PortfolioScientific Reports2045-23222023-08-011311610.1038/s41598-023-40647-yCausal relationship between endometriosis with infertility and ankylosing spondylitisJian-xiong Wang0Yue Shen1Xi-le Wang2Lin-li Ma3Sheng-qian Xu4Department of Rheumatology & Immunology, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Rheumatology & Immunology, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Rheumatology & Immunology, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Rheumatology & Immunology, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Rheumatology & Immunology, The First Affiliated Hospital of Anhui Medical UniversityAbstract Retrospective studies have identified an increased risk of ankylosing spondylitis (AS) in endometriosis patients. The purpose of this study was to investigate the causal relationship between clinical phenotypes of endometriosis and AS using mendelian randomized analysis (MR). MR was performed using data from genome-wide association studies (GWASs). Heterogeneity, pleiotropy and sensitivity analyses were performed to evaluate the robustness of the results by MR Egger and inverse variance weighted (IVW), leave-one-out analysis. IVW, IVW-MRE (inverse variance weighted multiplicative random effects), weighted median and MR Egger were used to explore the relationship between endometriosis and AS. The IVW analysis showed a causal relationship between infertile endometriosis and AS (OR = 0.8334, P = 0.02191), and the same result was observed with IVW-MRE (OR = 0.8334, P = 0.0007933). However, further stratified analysis showed that no matter which statistical method was used, ovarian endometriosis (IVW: OR = 0.1662, P = 0.4986; IVW-MRE: OR = 0.1662, P = 0.4986; MR Egger: OR = − 0.9577, P = 0.2798; Weighted median: OR = 0.2628, P = 0.3452), pelvic peritoneum endometriosis (IVW: OR = 0.4363, P = 0.225; IVW-MRE: OR = 0.4363, P = 0.225, MR Egger: OR = 4.159, P = 0.1705; Weighted median: OR = 0.4112, P = 0.2714), rectovaginal endometriosis (IVW: OR = 0.1365, P = 0.805; IVW-MRE: OR = 0.1365, P = 0.805) there was no causal relationship between endometriosis and AS. This study suggested that patients with infertility endometriosis are at increased risk for AS. This study supports clinicians to pay more attention to the occurrence of AS in endometriosis patients with infertility.https://doi.org/10.1038/s41598-023-40647-y |
| spellingShingle | Jian-xiong Wang Yue Shen Xi-le Wang Lin-li Ma Sheng-qian Xu Causal relationship between endometriosis with infertility and ankylosing spondylitis Scientific Reports |
| title | Causal relationship between endometriosis with infertility and ankylosing spondylitis |
| title_full | Causal relationship between endometriosis with infertility and ankylosing spondylitis |
| title_fullStr | Causal relationship between endometriosis with infertility and ankylosing spondylitis |
| title_full_unstemmed | Causal relationship between endometriosis with infertility and ankylosing spondylitis |
| title_short | Causal relationship between endometriosis with infertility and ankylosing spondylitis |
| title_sort | causal relationship between endometriosis with infertility and ankylosing spondylitis |
| url | https://doi.org/10.1038/s41598-023-40647-y |
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