TRPV1 Is Associated with Testicular Apoptosis in Mice
Reproductive potential decreases with age. A decrease in male fertility is due to a combination of morphological and molecular alterations in the testes. Transient receptor potential vanilloid receptor-1 (TRPV1) is associated with aging and lifespan, and its activation causes apoptotic cell death in...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Society of Animal Reproduction and Biotechnology
2019-12-01
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| Series: | Journal of Animal Reproduction and Biotechnology |
| Subjects: | |
| Online Access: | http://www.e-jarb.org/journal/view.html?uid=2500&vmd=Full |
| _version_ | 1818992550872088576 |
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| author | Adrian S. Siregar Marie Merci Nyiramana Eun-Jin Kim Eui-Jung Shin Chang-Woon Kim Dong Kun Lee Seong-Geun Hong Jaehee Han Dawon Kang |
| author_facet | Adrian S. Siregar Marie Merci Nyiramana Eun-Jin Kim Eui-Jung Shin Chang-Woon Kim Dong Kun Lee Seong-Geun Hong Jaehee Han Dawon Kang |
| author_sort | Adrian S. Siregar |
| collection | DOAJ |
| description | Reproductive potential decreases with age. A decrease in male fertility is due to a combination of morphological and molecular alterations in the testes. Transient receptor potential vanilloid receptor-1 (TRPV1) is associated with aging and lifespan, and its activation causes apoptotic cell death in various cell types. However, the effect of TRPV1 on testicular apoptosis in aged mice has not yet been reported. TRPV1 knockout (KO) mice had a longer lifespan than that of wild-type (WT) mice. Lifespan was increased by 11.8% in male TRPV1 KO mice compared to that in WT mice. TRPV1 KO males lived approximately 100 days longer than WT males on average, and the maximum lifespan was markedly extended in TRPV1 KO mice compared with that in WT mice. The TRPV1 expression levels were highly increased in the testes of older mice. TRPV1 was expressed in the entire testes region of the old mice. In addition, old TRPV1 KO mice had lower testicular apoptosis than that of WT mice. Our results show that TRPV1 induces testicular apoptosis and suggest that TRPV1 may be associated with testicular aging. |
| first_indexed | 2024-12-20T20:27:57Z |
| format | Article |
| id | doaj.art-446647ee02c541c7b6e4b42e65f0eb65 |
| institution | Directory Open Access Journal |
| issn | 2671-4639 2671-4663 |
| language | English |
| last_indexed | 2024-12-20T20:27:57Z |
| publishDate | 2019-12-01 |
| publisher | The Korean Society of Animal Reproduction and Biotechnology |
| record_format | Article |
| series | Journal of Animal Reproduction and Biotechnology |
| spelling | doaj.art-446647ee02c541c7b6e4b42e65f0eb652022-12-21T19:27:25ZengThe Korean Society of Animal Reproduction and BiotechnologyJournal of Animal Reproduction and Biotechnology2671-46392671-46632019-12-0134331131710.12750/JARB.34.4.311TRPV1 Is Associated with Testicular Apoptosis in MiceAdrian S. Siregar0Marie Merci Nyiramana1Eun-Jin Kim2Eui-Jung Shin3Chang-Woon Kim4Dong Kun Lee5Seong-Geun Hong6Jaehee Han7Dawon Kang8Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, KoreaDepartment of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, KoreaDepartment of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, KoreaDepartment of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, KoreaDepartment of Obstetrics and Gynecology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, KoreaDepartment of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, KoreaDepartment of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, KoreaDepartment of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, KoreaDepartment of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52727, KoreaReproductive potential decreases with age. A decrease in male fertility is due to a combination of morphological and molecular alterations in the testes. Transient receptor potential vanilloid receptor-1 (TRPV1) is associated with aging and lifespan, and its activation causes apoptotic cell death in various cell types. However, the effect of TRPV1 on testicular apoptosis in aged mice has not yet been reported. TRPV1 knockout (KO) mice had a longer lifespan than that of wild-type (WT) mice. Lifespan was increased by 11.8% in male TRPV1 KO mice compared to that in WT mice. TRPV1 KO males lived approximately 100 days longer than WT males on average, and the maximum lifespan was markedly extended in TRPV1 KO mice compared with that in WT mice. The TRPV1 expression levels were highly increased in the testes of older mice. TRPV1 was expressed in the entire testes region of the old mice. In addition, old TRPV1 KO mice had lower testicular apoptosis than that of WT mice. Our results show that TRPV1 induces testicular apoptosis and suggest that TRPV1 may be associated with testicular aging.http://www.e-jarb.org/journal/view.html?uid=2500&vmd=Fullagingapoptosismicetestestrpv1 receptor |
| spellingShingle | Adrian S. Siregar Marie Merci Nyiramana Eun-Jin Kim Eui-Jung Shin Chang-Woon Kim Dong Kun Lee Seong-Geun Hong Jaehee Han Dawon Kang TRPV1 Is Associated with Testicular Apoptosis in Mice Journal of Animal Reproduction and Biotechnology aging apoptosis mice testes trpv1 receptor |
| title | TRPV1 Is Associated with Testicular Apoptosis in Mice |
| title_full | TRPV1 Is Associated with Testicular Apoptosis in Mice |
| title_fullStr | TRPV1 Is Associated with Testicular Apoptosis in Mice |
| title_full_unstemmed | TRPV1 Is Associated with Testicular Apoptosis in Mice |
| title_short | TRPV1 Is Associated with Testicular Apoptosis in Mice |
| title_sort | trpv1 is associated with testicular apoptosis in mice |
| topic | aging apoptosis mice testes trpv1 receptor |
| url | http://www.e-jarb.org/journal/view.html?uid=2500&vmd=Full |
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