Silica-zinc chloride (SiO2-ZnCl2) catalyzed Michael addition reaction of active methylene compounds to β-nitrostyrenes: Synthesis of functionalized pyrazole derivatives
Under solvent-free conditions, a simple and efficient procedure has been developed for the Michael addition reaction of active methylene compounds to β-nitrostyrenes. The resulting Michael adducts are efficiently converted into functionalized pyrazole derivatives with hydrazine hydrate in e...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Growing Science
2023-01-01
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| Series: | Current Chemistry Letters |
| Online Access: | http://www.growingscience.com/ccl/Vol12/ccl_2022_45.pdf |
| _version_ | 1811241515819728896 |
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| author | V. B. R. K. Krishnan Santha Kumari Merugu V. Siva Rama Krishna Reddy Hari Babu Bollikolla |
| author_facet | V. B. R. K. Krishnan Santha Kumari Merugu V. Siva Rama Krishna Reddy Hari Babu Bollikolla |
| author_sort | V. B. R. K. Krishnan |
| collection | DOAJ |
| description | Under solvent-free conditions, a simple and efficient procedure has been developed for the Michael addition reaction of active methylene compounds to β-nitrostyrenes. The resulting Michael adducts are efficiently converted into functionalized pyrazole derivatives with hydrazine hydrate in excellent yields. All the compounds were well characterized by spectroscopic techniques. |
| first_indexed | 2024-04-12T13:37:21Z |
| format | Article |
| id | doaj.art-44669376f47f497fae9c4b19036cd525 |
| institution | Directory Open Access Journal |
| issn | 1927-7296 1927-730X |
| language | English |
| last_indexed | 2024-04-12T13:37:21Z |
| publishDate | 2023-01-01 |
| publisher | Growing Science |
| record_format | Article |
| series | Current Chemistry Letters |
| spelling | doaj.art-44669376f47f497fae9c4b19036cd5252022-12-22T03:30:58ZengGrowing ScienceCurrent Chemistry Letters1927-72961927-730X2023-01-01121172610.5267/j.ccl.2022.10.001Silica-zinc chloride (SiO2-ZnCl2) catalyzed Michael addition reaction of active methylene compounds to β-nitrostyrenes: Synthesis of functionalized pyrazole derivativesV. B. R. K. KrishnanSantha Kumari MeruguV. Siva Rama Krishna ReddyHari Babu Bollikolla Under solvent-free conditions, a simple and efficient procedure has been developed for the Michael addition reaction of active methylene compounds to β-nitrostyrenes. The resulting Michael adducts are efficiently converted into functionalized pyrazole derivatives with hydrazine hydrate in excellent yields. All the compounds were well characterized by spectroscopic techniques.http://www.growingscience.com/ccl/Vol12/ccl_2022_45.pdf |
| spellingShingle | V. B. R. K. Krishnan Santha Kumari Merugu V. Siva Rama Krishna Reddy Hari Babu Bollikolla Silica-zinc chloride (SiO2-ZnCl2) catalyzed Michael addition reaction of active methylene compounds to β-nitrostyrenes: Synthesis of functionalized pyrazole derivatives Current Chemistry Letters |
| title | Silica-zinc chloride (SiO2-ZnCl2) catalyzed Michael addition reaction of active methylene compounds to β-nitrostyrenes: Synthesis of functionalized pyrazole derivatives |
| title_full | Silica-zinc chloride (SiO2-ZnCl2) catalyzed Michael addition reaction of active methylene compounds to β-nitrostyrenes: Synthesis of functionalized pyrazole derivatives |
| title_fullStr | Silica-zinc chloride (SiO2-ZnCl2) catalyzed Michael addition reaction of active methylene compounds to β-nitrostyrenes: Synthesis of functionalized pyrazole derivatives |
| title_full_unstemmed | Silica-zinc chloride (SiO2-ZnCl2) catalyzed Michael addition reaction of active methylene compounds to β-nitrostyrenes: Synthesis of functionalized pyrazole derivatives |
| title_short | Silica-zinc chloride (SiO2-ZnCl2) catalyzed Michael addition reaction of active methylene compounds to β-nitrostyrenes: Synthesis of functionalized pyrazole derivatives |
| title_sort | silica zinc chloride sio2 zncl2 catalyzed michael addition reaction of active methylene compounds to β nitrostyrenes synthesis of functionalized pyrazole derivatives |
| url | http://www.growingscience.com/ccl/Vol12/ccl_2022_45.pdf |
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