Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer
We evaluated the role of free prostate specific antigen (f-PSA) serum level and its related parameters in detecting prostate cancer. This retrospective study was conducted between January 2006 and March 2008. Trans-rectal ultrasound guided prostate biopsy was performed for 107 patients who had total...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2011;volume=22;issue=2;spage=291;epage=297;aulast=Haroun |
| _version_ | 1818084956995321856 |
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| author | Azmi A Haroun Azmy S Hadidy Ziad M Awwad Caramella F Nimri Waleed S Mahafza Emad S Tarawneh |
| author_facet | Azmi A Haroun Azmy S Hadidy Ziad M Awwad Caramella F Nimri Waleed S Mahafza Emad S Tarawneh |
| author_sort | Azmi A Haroun |
| collection | DOAJ |
| description | We evaluated the role of free prostate specific antigen (f-PSA) serum level and its related parameters in detecting prostate cancer. This retrospective study was conducted between January 2006 and March 2008. Trans-rectal ultrasound guided prostate biopsy was performed for 107 patients who had total PSA (t-PSA) level of either >4 ng/mL with or without palpable nodule or ≤4 ng/mL with palpable nodule on digital rectal examination. The perfor-mance measurements for f-PSA, percent free PSA (%f-PSA) and free PSA density (f-PSAD) were determined and compared with those for t-PSA and total PSA density (t-PSAD). Descriptive statistics for all variables of interest were calculated, and receiver operating characteristic curves were generated. Nine patients (8.4%) had normal histology, 69 patients (64.4%) had benign disease and 29 patients (27.1%) had prostate cancer. The performance of f-PSA in PCa detection was better than other evaluated parameters. The largest area under the curve for patients in the gray area (t-PSA range 4.1-10 ng/mL) was for f-PSA, with a value of 0.64 and a sensitivity and specificity of 44% and 87%, respectively. For %f-PSA, these values were 0.59, 63% and 62%, respectively. For patients with a t-PSA level of 10.1-20 ng/mL, they were 0.68, 67%, and 81%, respectively, for f-PSA, and 0.64, 67%, and 76%, respectively, for %f-PSA. In conclusion, f-PSA serum levels performed better than free to total PSA ratio and t-PSA for prostate cancer screening. It is of clinical value which could affect the biopsy decision avoiding unnecessary interventions. |
| first_indexed | 2024-12-10T20:02:08Z |
| format | Article |
| id | doaj.art-4468dc86c6254588bdeb3eccb76afb7a |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-12-10T20:02:08Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-4468dc86c6254588bdeb3eccb76afb7a2022-12-22T01:35:30ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422011-01-01222291297Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancerAzmi A HarounAzmy S HadidyZiad M AwwadCaramella F NimriWaleed S MahafzaEmad S TarawnehWe evaluated the role of free prostate specific antigen (f-PSA) serum level and its related parameters in detecting prostate cancer. This retrospective study was conducted between January 2006 and March 2008. Trans-rectal ultrasound guided prostate biopsy was performed for 107 patients who had total PSA (t-PSA) level of either >4 ng/mL with or without palpable nodule or ≤4 ng/mL with palpable nodule on digital rectal examination. The perfor-mance measurements for f-PSA, percent free PSA (%f-PSA) and free PSA density (f-PSAD) were determined and compared with those for t-PSA and total PSA density (t-PSAD). Descriptive statistics for all variables of interest were calculated, and receiver operating characteristic curves were generated. Nine patients (8.4%) had normal histology, 69 patients (64.4%) had benign disease and 29 patients (27.1%) had prostate cancer. The performance of f-PSA in PCa detection was better than other evaluated parameters. The largest area under the curve for patients in the gray area (t-PSA range 4.1-10 ng/mL) was for f-PSA, with a value of 0.64 and a sensitivity and specificity of 44% and 87%, respectively. For %f-PSA, these values were 0.59, 63% and 62%, respectively. For patients with a t-PSA level of 10.1-20 ng/mL, they were 0.68, 67%, and 81%, respectively, for f-PSA, and 0.64, 67%, and 76%, respectively, for %f-PSA. In conclusion, f-PSA serum levels performed better than free to total PSA ratio and t-PSA for prostate cancer screening. It is of clinical value which could affect the biopsy decision avoiding unnecessary interventions.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2011;volume=22;issue=2;spage=291;epage=297;aulast=Haroun |
| spellingShingle | Azmi A Haroun Azmy S Hadidy Ziad M Awwad Caramella F Nimri Waleed S Mahafza Emad S Tarawneh Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer Saudi Journal of Kidney Diseases and Transplantation |
| title | Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer |
| title_full | Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer |
| title_fullStr | Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer |
| title_full_unstemmed | Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer |
| title_short | Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer |
| title_sort | utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2011;volume=22;issue=2;spage=291;epage=297;aulast=Haroun |
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