The functional duality of SGK1 in the regulation of hyperglycemia
Hyperglycemia is the consequence of blood glucose dysregulation and a driving force of diabetic complications including retinopathy, nephropathy and cardiovascular diseases. The serum and glucocorticoid inducible kinase-1 (SGK1) has been suggested in the modulation of various pathophysiological acti...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2020-08-01
|
| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/9/7/EC-20-0225.xml |
| _version_ | 1818541491959627776 |
|---|---|
| author | Chunliang Yang Junyi Li Fei Sun Haifeng Zhou Jia Yang Chao Yang |
| author_facet | Chunliang Yang Junyi Li Fei Sun Haifeng Zhou Jia Yang Chao Yang |
| author_sort | Chunliang Yang |
| collection | DOAJ |
| description | Hyperglycemia is the consequence of blood glucose dysregulation and a driving force of diabetic complications including retinopathy, nephropathy and cardiovascular diseases. The serum and glucocorticoid inducible kinase-1 (SGK1) has been suggested in the modulation of various pathophysiological activities. However, the role of SGK1 in blood glucose homeostasis remains less appreciated. In this review, we intend to summarize the function of SGK1 in glucose level regulation and to examine the evidence supporting the therapeutic potential of SGK1 inhibitors in hyperglycemia. Ample evidence points to the controversial roles of SGK1 in pancreatic insulin secretion and peripheral insulin sensitivity, which reflects the complex interplay between SGK1 activation and blood glucose fluctuation. Furthermore, SGK1 is engaged in glucose absorption and excretion in intestine and kidney and participates in the progression of hyperglycemia-induced secondary organ damage. As a net effect, blockage of SGK1 activation via either pharmacological inhibition or genetic manipulation seems to be helpful in glucose control at varying diabetic stages. |
| first_indexed | 2024-12-11T22:09:59Z |
| format | Article |
| id | doaj.art-44691ac2a03b435998ee25191aeb9921 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-11T22:09:59Z |
| publishDate | 2020-08-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-44691ac2a03b435998ee25191aeb99212022-12-22T00:48:50ZengBioscientificaEndocrine Connections2049-36142049-36142020-08-0197R187R194https://doi.org/10.1530/EC-20-0225The functional duality of SGK1 in the regulation of hyperglycemiaChunliang Yang0Junyi Li1Fei Sun2Haifeng Zhou3Jia Yang4Chao Yang5Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; The Center for Biomedical Research, Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaThe Center for Biomedical Research, Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Gerontology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, ChinaHyperglycemia is the consequence of blood glucose dysregulation and a driving force of diabetic complications including retinopathy, nephropathy and cardiovascular diseases. The serum and glucocorticoid inducible kinase-1 (SGK1) has been suggested in the modulation of various pathophysiological activities. However, the role of SGK1 in blood glucose homeostasis remains less appreciated. In this review, we intend to summarize the function of SGK1 in glucose level regulation and to examine the evidence supporting the therapeutic potential of SGK1 inhibitors in hyperglycemia. Ample evidence points to the controversial roles of SGK1 in pancreatic insulin secretion and peripheral insulin sensitivity, which reflects the complex interplay between SGK1 activation and blood glucose fluctuation. Furthermore, SGK1 is engaged in glucose absorption and excretion in intestine and kidney and participates in the progression of hyperglycemia-induced secondary organ damage. As a net effect, blockage of SGK1 activation via either pharmacological inhibition or genetic manipulation seems to be helpful in glucose control at varying diabetic stages.https://ec.bioscientifica.com/view/journals/ec/9/7/EC-20-0225.xmlsgk1hyperglycemiainsulin resistanceblood glucose homeostasis |
| spellingShingle | Chunliang Yang Junyi Li Fei Sun Haifeng Zhou Jia Yang Chao Yang The functional duality of SGK1 in the regulation of hyperglycemia Endocrine Connections sgk1 hyperglycemia insulin resistance blood glucose homeostasis |
| title | The functional duality of SGK1 in the regulation of hyperglycemia |
| title_full | The functional duality of SGK1 in the regulation of hyperglycemia |
| title_fullStr | The functional duality of SGK1 in the regulation of hyperglycemia |
| title_full_unstemmed | The functional duality of SGK1 in the regulation of hyperglycemia |
| title_short | The functional duality of SGK1 in the regulation of hyperglycemia |
| title_sort | functional duality of sgk1 in the regulation of hyperglycemia |
| topic | sgk1 hyperglycemia insulin resistance blood glucose homeostasis |
| url | https://ec.bioscientifica.com/view/journals/ec/9/7/EC-20-0225.xml |
| work_keys_str_mv | AT chunliangyang thefunctionaldualityofsgk1intheregulationofhyperglycemia AT junyili thefunctionaldualityofsgk1intheregulationofhyperglycemia AT feisun thefunctionaldualityofsgk1intheregulationofhyperglycemia AT haifengzhou thefunctionaldualityofsgk1intheregulationofhyperglycemia AT jiayang thefunctionaldualityofsgk1intheregulationofhyperglycemia AT chaoyang thefunctionaldualityofsgk1intheregulationofhyperglycemia AT chunliangyang functionaldualityofsgk1intheregulationofhyperglycemia AT junyili functionaldualityofsgk1intheregulationofhyperglycemia AT feisun functionaldualityofsgk1intheregulationofhyperglycemia AT haifengzhou functionaldualityofsgk1intheregulationofhyperglycemia AT jiayang functionaldualityofsgk1intheregulationofhyperglycemia AT chaoyang functionaldualityofsgk1intheregulationofhyperglycemia |