Alterations in Glomerular Filtration Rates Using Different Algorithms in the Korean Population Visiting Local Clinics and Hospitals
We retrospectively reviewed the estimated glomerular filtration rates (eGFR) calculated by three equations: (1) Modification of Diet in Renal Disease Study (MDRD), (2) Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) using serum creatinine in 2009 (CKD-EPI 2009), and (3) CKD-EPI suggested...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/18/5339 |
| _version_ | 1797486690373206016 |
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| author | Rihwa Choi Sang Gon Lee Eun Hee Lee |
| author_facet | Rihwa Choi Sang Gon Lee Eun Hee Lee |
| author_sort | Rihwa Choi |
| collection | DOAJ |
| description | We retrospectively reviewed the estimated glomerular filtration rates (eGFR) calculated by three equations: (1) Modification of Diet in Renal Disease Study (MDRD), (2) Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) using serum creatinine in 2009 (CKD-EPI 2009), and (3) CKD-EPI suggested in 2021 (CKD-EPI 2021), in an adult Korean population visiting local clinics and hospitals for health check-ups between 2019 and 2021 to investigate the effect of changes in the prevalence of chronic kidney diseases using those equations. During the study period, serum creatinine tests were performed on 442,566 subjects (205,236 men and 237,330 women). The overall prevalence rates of decreased eGFR (<60 mL/min/1.73 m<sup>2</sup>) at baseline measurement were as follows: 3.4% using MDRD, 2.8% using CKD-EPI 2009, and 2.1% using CKD-EPI 2021. The prevalence of decreased eGFR increased with age. Among 442,566 tests, specimens having simultaneously measured random urine dipstick tests for proteinuria represented 6.0% of the population, and the albumin-creatinine ratio (ACR) was 0.3%. The prevalence of specimens having both decreased eGFR and proteinuria was significantly different among equations (<i>p</i> < 0.05). Among the three equations, MDRD and CKD-EPI 2009 had a similar specimen prevalence of decreased eGFR and proteinuria (≥1+) using a dipstick test or albuminuria (urine ACR > 30 mg/g creatinine), while those based on CKD-EPI 2021 were about half of those based on MDRD and CKD-EPI 2009. Future studies are needed to clarify the clinical impact of the changes in the calculations for eGFR. |
| first_indexed | 2024-03-09T23:36:52Z |
| format | Article |
| id | doaj.art-446a12556ad84b58be8290a2056eb7d2 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:36:52Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-446a12556ad84b58be8290a2056eb7d22023-11-23T16:59:02ZengMDPI AGJournal of Clinical Medicine2077-03832022-09-011118533910.3390/jcm11185339Alterations in Glomerular Filtration Rates Using Different Algorithms in the Korean Population Visiting Local Clinics and HospitalsRihwa Choi0Sang Gon Lee1Eun Hee Lee2Department of Laboratory Medicine, Green Cross Laboratories, Yongin 16924, KoreaDepartment of Laboratory Medicine, Green Cross Laboratories, Yongin 16924, KoreaGreen Cross Laboratories, Yongin 16924, KoreaWe retrospectively reviewed the estimated glomerular filtration rates (eGFR) calculated by three equations: (1) Modification of Diet in Renal Disease Study (MDRD), (2) Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) using serum creatinine in 2009 (CKD-EPI 2009), and (3) CKD-EPI suggested in 2021 (CKD-EPI 2021), in an adult Korean population visiting local clinics and hospitals for health check-ups between 2019 and 2021 to investigate the effect of changes in the prevalence of chronic kidney diseases using those equations. During the study period, serum creatinine tests were performed on 442,566 subjects (205,236 men and 237,330 women). The overall prevalence rates of decreased eGFR (<60 mL/min/1.73 m<sup>2</sup>) at baseline measurement were as follows: 3.4% using MDRD, 2.8% using CKD-EPI 2009, and 2.1% using CKD-EPI 2021. The prevalence of decreased eGFR increased with age. Among 442,566 tests, specimens having simultaneously measured random urine dipstick tests for proteinuria represented 6.0% of the population, and the albumin-creatinine ratio (ACR) was 0.3%. The prevalence of specimens having both decreased eGFR and proteinuria was significantly different among equations (<i>p</i> < 0.05). Among the three equations, MDRD and CKD-EPI 2009 had a similar specimen prevalence of decreased eGFR and proteinuria (≥1+) using a dipstick test or albuminuria (urine ACR > 30 mg/g creatinine), while those based on CKD-EPI 2021 were about half of those based on MDRD and CKD-EPI 2009. Future studies are needed to clarify the clinical impact of the changes in the calculations for eGFR.https://www.mdpi.com/2077-0383/11/18/5339glomerular filtration rateequationchronic kidney diseaseproteinuriaalbuminuriaKorea |
| spellingShingle | Rihwa Choi Sang Gon Lee Eun Hee Lee Alterations in Glomerular Filtration Rates Using Different Algorithms in the Korean Population Visiting Local Clinics and Hospitals Journal of Clinical Medicine glomerular filtration rate equation chronic kidney disease proteinuria albuminuria Korea |
| title | Alterations in Glomerular Filtration Rates Using Different Algorithms in the Korean Population Visiting Local Clinics and Hospitals |
| title_full | Alterations in Glomerular Filtration Rates Using Different Algorithms in the Korean Population Visiting Local Clinics and Hospitals |
| title_fullStr | Alterations in Glomerular Filtration Rates Using Different Algorithms in the Korean Population Visiting Local Clinics and Hospitals |
| title_full_unstemmed | Alterations in Glomerular Filtration Rates Using Different Algorithms in the Korean Population Visiting Local Clinics and Hospitals |
| title_short | Alterations in Glomerular Filtration Rates Using Different Algorithms in the Korean Population Visiting Local Clinics and Hospitals |
| title_sort | alterations in glomerular filtration rates using different algorithms in the korean population visiting local clinics and hospitals |
| topic | glomerular filtration rate equation chronic kidney disease proteinuria albuminuria Korea |
| url | https://www.mdpi.com/2077-0383/11/18/5339 |
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