Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients
BackgroundThe relationship between ideal cardiovascular health reflected in the cardiovascular health score (CVHS) and valvular heart disease is not known. The purpose of this study was to determine the association of CVHS attainment through midlife to late life with aortic stenosis prevalence and s...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-02-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.117.007234 |
| _version_ | 1819178449887035392 |
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| author | Morten Sengeløv Susan Cheng Tor Biering‐Sørensen Kunihiro Matsushita Suma Konety Scott D. Solomon Aaron R. Folsom Amil M. Shah |
| author_facet | Morten Sengeløv Susan Cheng Tor Biering‐Sørensen Kunihiro Matsushita Suma Konety Scott D. Solomon Aaron R. Folsom Amil M. Shah |
| author_sort | Morten Sengeløv |
| collection | DOAJ |
| description | BackgroundThe relationship between ideal cardiovascular health reflected in the cardiovascular health score (CVHS) and valvular heart disease is not known. The purpose of this study was to determine the association of CVHS attainment through midlife to late life with aortic stenosis prevalence and severity in late life. Methods and ResultsThe following 6 ideal cardiovascular health metrics were assessed in ARIC (Atherosclerosis Risk in Communities) Study participants at 5 examination visits between 1987 and 2013 (visits 1–4 in 1987–1998 and visit 5 in 2011–2013): smoking, body mass index, total cholesterol, blood pressure, physical activity, and blood glucose. Percentage attained CVHS was calculated in 6034 participants as the sum of CVHS at each visit/the maximum possible score. Aortic stenosis was assessed by echocardiography at visit 5 on the basis of the peak aortic valve velocity. Aortic stenosis was categorized sclerosis, mild stenosis, and moderate‐to‐severe stenosis. Mean age was 76±5 years, 42% were men, and 22% were black. Mean percentage attained CVHS was 63±14%, and the prevalence of aortic stenosis stages were 15.9% for sclerosis, 4.3% for mild stenosis, and 0.7% for moderate‐to‐severe stenosis. Worse percentage attained CVHS was associated with higher prevalence of aortic sclerosis (P<0.001 for trend), mild stenosis (P<0.001), and moderate‐to‐severe stenosis (P=0.002), adjusting for age, sex, and race. ConclusionsGreater attainment of ideal cardiovascular health in midlife to late life is associated with a lower prevalence of aortic sclerosis and stenosis in late life in a large cohort of older adults. |
| first_indexed | 2024-12-22T21:42:44Z |
| format | Article |
| id | doaj.art-446b3e1ccb6648828c508f54c4fbc8cf |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-22T21:42:44Z |
| publishDate | 2018-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-446b3e1ccb6648828c508f54c4fbc8cf2022-12-21T18:11:34ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802018-02-017310.1161/JAHA.117.007234Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly PatientsMorten Sengeløv0Susan Cheng1Tor Biering‐Sørensen2Kunihiro Matsushita3Suma Konety4Scott D. Solomon5Aaron R. Folsom6Amil M. Shah7Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MADivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MADivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MADepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MDDivision of Cardiology, University of Minnesota, Minneapolis, MNDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MADivision of Epidemiology and Community Health, and School of Public Health, University of Minnesota, Minneapolis, MNDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MABackgroundThe relationship between ideal cardiovascular health reflected in the cardiovascular health score (CVHS) and valvular heart disease is not known. The purpose of this study was to determine the association of CVHS attainment through midlife to late life with aortic stenosis prevalence and severity in late life. Methods and ResultsThe following 6 ideal cardiovascular health metrics were assessed in ARIC (Atherosclerosis Risk in Communities) Study participants at 5 examination visits between 1987 and 2013 (visits 1–4 in 1987–1998 and visit 5 in 2011–2013): smoking, body mass index, total cholesterol, blood pressure, physical activity, and blood glucose. Percentage attained CVHS was calculated in 6034 participants as the sum of CVHS at each visit/the maximum possible score. Aortic stenosis was assessed by echocardiography at visit 5 on the basis of the peak aortic valve velocity. Aortic stenosis was categorized sclerosis, mild stenosis, and moderate‐to‐severe stenosis. Mean age was 76±5 years, 42% were men, and 22% were black. Mean percentage attained CVHS was 63±14%, and the prevalence of aortic stenosis stages were 15.9% for sclerosis, 4.3% for mild stenosis, and 0.7% for moderate‐to‐severe stenosis. Worse percentage attained CVHS was associated with higher prevalence of aortic sclerosis (P<0.001 for trend), mild stenosis (P<0.001), and moderate‐to‐severe stenosis (P=0.002), adjusting for age, sex, and race. ConclusionsGreater attainment of ideal cardiovascular health in midlife to late life is associated with a lower prevalence of aortic sclerosis and stenosis in late life in a large cohort of older adults.https://www.ahajournals.org/doi/10.1161/JAHA.117.007234aortic stenosisechocardiographyepidemiologyprimary preventionrisk factor |
| spellingShingle | Morten Sengeløv Susan Cheng Tor Biering‐Sørensen Kunihiro Matsushita Suma Konety Scott D. Solomon Aaron R. Folsom Amil M. Shah Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease aortic stenosis echocardiography epidemiology primary prevention risk factor |
| title | Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients |
| title_full | Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients |
| title_fullStr | Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients |
| title_full_unstemmed | Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients |
| title_short | Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients |
| title_sort | ideal cardiovascular health and the prevalence and severity of aortic stenosis in elderly patients |
| topic | aortic stenosis echocardiography epidemiology primary prevention risk factor |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.117.007234 |
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