IL-17 and CCR9+α4β7– Th17 Cells Promote Salivary Gland Inflammation, Dysfunction, and Cell Death in Sjögren’s Syndrome

IL-17 and CCR9+α4β7– Th17 Cells Promote Salivary Gland Inflammation, Dysfunction, and Cell Death in Sjögren’s Syndrome

Previous studies have evaluated the roles of T and B cells in the pathogenesis of Sjögren’s syndrome (SS); however, their relationships with age-dependent and metabolic abnormalities remain unclear. We examined the impacts of changes associated with aging or metabolic abnormalities on populations of...

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Main Authors: Sun-Hee Hwang, Jin Seok Woo, Jeonghyeon Moon, SeungCheon Yang, Jin-Sil Park, JaeSeon Lee, JeongWon Choi, Kun Hee Lee, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
Sjögren’s syndrome
aging
interleukin 17
gut-homing
retinoic acid
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.721453/full

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