Benefits of Regular Exercise on Inflammatory and Cardiovascular Risk Markers in Normal Weight, Overweight and Obese Adults.
Obesity is a worldwide epidemic that increases the risk of several well-known co-morbidities. There is a complicated relationship between adipokines and low-grade inflammation in obesity and cardiovascular disease (CVD). Physical activity practices have beneficial health effects on obesity and relat...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4608693?pdf=render |
| _version_ | 1811282567147552768 |
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| author | Olivia Santos Gondim Vinicius Tadeu Nunes de Camargo Fernanda Almeida Gutierrez Patricia Fátima de Oliveira Martins Maria Elizabeth Pereira Passos Cesar Miguel Momesso Vinicius Coneglian Santos Renata Gorjão Tania Cristina Pithon-Curi Maria Fernanda Cury-Boaventura |
| author_facet | Olivia Santos Gondim Vinicius Tadeu Nunes de Camargo Fernanda Almeida Gutierrez Patricia Fátima de Oliveira Martins Maria Elizabeth Pereira Passos Cesar Miguel Momesso Vinicius Coneglian Santos Renata Gorjão Tania Cristina Pithon-Curi Maria Fernanda Cury-Boaventura |
| author_sort | Olivia Santos Gondim |
| collection | DOAJ |
| description | Obesity is a worldwide epidemic that increases the risk of several well-known co-morbidities. There is a complicated relationship between adipokines and low-grade inflammation in obesity and cardiovascular disease (CVD). Physical activity practices have beneficial health effects on obesity and related disorders such as hypertension and dyslipidemia. We investigated the effects of 6 and 12 months of moderate physical training on the levels of adipokines and CVD markers in normal weight, overweight and obese volunteers. The 143 participants were followed up at baseline and after six and twelfth months of moderate regular exercise, 2 times a week, for 12 months. The volunteers were distributed into 3 groups: Normal Weight Group (NWG,), Overweight Group (OVG) and Obese Group (OBG). We evaluated blood pressure, resting heart rate, anthropometric parameters, body composition, fitness capacity (VO2max and isometric back strength), cardiovascular markers (CRP, total cholesterol, LDL-c, HDL-c, homocysteine) and adipokine levels (leptin, adiponectin, resistin, IL-6 and TNF-alpha). There were no significant changes in anthropometric parameters and body composition in any of the groups following 6 and 12 months of exercise training. Leptin, IL-6 levels and systolic blood pressure were significantly elevated in OBG before the training. Regular exercise decreased HDL-c, leptin, adiponectin and resistin levels and diastolic blood pressure in OVG. In OBG, exercise diminished HDL-c, homocysteine, leptin, resistin, IL-6, adiponectin. Moderate exercise had no effect on the body composition; however, exercise did promote beneficial effects on the low-grade inflammatory state and CVD clinical markers in overweight and obese individuals. |
| first_indexed | 2024-04-13T01:53:44Z |
| format | Article |
| id | doaj.art-446ebae1a39e45a9816136f33a7b5365 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T01:53:44Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-446ebae1a39e45a9816136f33a7b53652022-12-22T03:07:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011010e014059610.1371/journal.pone.0140596Benefits of Regular Exercise on Inflammatory and Cardiovascular Risk Markers in Normal Weight, Overweight and Obese Adults.Olivia Santos GondimVinicius Tadeu Nunes de CamargoFernanda Almeida GutierrezPatricia Fátima de Oliveira MartinsMaria Elizabeth Pereira PassosCesar Miguel MomessoVinicius Coneglian SantosRenata GorjãoTania Cristina Pithon-CuriMaria Fernanda Cury-BoaventuraObesity is a worldwide epidemic that increases the risk of several well-known co-morbidities. There is a complicated relationship between adipokines and low-grade inflammation in obesity and cardiovascular disease (CVD). Physical activity practices have beneficial health effects on obesity and related disorders such as hypertension and dyslipidemia. We investigated the effects of 6 and 12 months of moderate physical training on the levels of adipokines and CVD markers in normal weight, overweight and obese volunteers. The 143 participants were followed up at baseline and after six and twelfth months of moderate regular exercise, 2 times a week, for 12 months. The volunteers were distributed into 3 groups: Normal Weight Group (NWG,), Overweight Group (OVG) and Obese Group (OBG). We evaluated blood pressure, resting heart rate, anthropometric parameters, body composition, fitness capacity (VO2max and isometric back strength), cardiovascular markers (CRP, total cholesterol, LDL-c, HDL-c, homocysteine) and adipokine levels (leptin, adiponectin, resistin, IL-6 and TNF-alpha). There were no significant changes in anthropometric parameters and body composition in any of the groups following 6 and 12 months of exercise training. Leptin, IL-6 levels and systolic blood pressure were significantly elevated in OBG before the training. Regular exercise decreased HDL-c, leptin, adiponectin and resistin levels and diastolic blood pressure in OVG. In OBG, exercise diminished HDL-c, homocysteine, leptin, resistin, IL-6, adiponectin. Moderate exercise had no effect on the body composition; however, exercise did promote beneficial effects on the low-grade inflammatory state and CVD clinical markers in overweight and obese individuals.http://europepmc.org/articles/PMC4608693?pdf=render |
| spellingShingle | Olivia Santos Gondim Vinicius Tadeu Nunes de Camargo Fernanda Almeida Gutierrez Patricia Fátima de Oliveira Martins Maria Elizabeth Pereira Passos Cesar Miguel Momesso Vinicius Coneglian Santos Renata Gorjão Tania Cristina Pithon-Curi Maria Fernanda Cury-Boaventura Benefits of Regular Exercise on Inflammatory and Cardiovascular Risk Markers in Normal Weight, Overweight and Obese Adults. PLoS ONE |
| title | Benefits of Regular Exercise on Inflammatory and Cardiovascular Risk Markers in Normal Weight, Overweight and Obese Adults. |
| title_full | Benefits of Regular Exercise on Inflammatory and Cardiovascular Risk Markers in Normal Weight, Overweight and Obese Adults. |
| title_fullStr | Benefits of Regular Exercise on Inflammatory and Cardiovascular Risk Markers in Normal Weight, Overweight and Obese Adults. |
| title_full_unstemmed | Benefits of Regular Exercise on Inflammatory and Cardiovascular Risk Markers in Normal Weight, Overweight and Obese Adults. |
| title_short | Benefits of Regular Exercise on Inflammatory and Cardiovascular Risk Markers in Normal Weight, Overweight and Obese Adults. |
| title_sort | benefits of regular exercise on inflammatory and cardiovascular risk markers in normal weight overweight and obese adults |
| url | http://europepmc.org/articles/PMC4608693?pdf=render |
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