Superoxide Dismutase Activities in Plasma of Patients with Breast Cancer
Background: Superoxide radicals are produced during oxidative metabolic processes, and removed by superoxide dismutase (SOD) enzymes. Controversial results have been reported regarding the tissue and plasma concentration of SOD in patients with breast cancer. Methods: Venous blood was obtained from...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Kaviani Breast Disease Institute
2014-08-01
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| Series: | Archives of Breast Cancer |
| Subjects: | |
| Online Access: | https://archbreastcancer.com/index.php/abc/article/view/6 |
| _version_ | 1818389702955237376 |
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| author | Fezzeh Elyasinia Venus Chegini Asieh Olfat-Bakhsh Parvin Pasalar Ali Aminian |
| author_facet | Fezzeh Elyasinia Venus Chegini Asieh Olfat-Bakhsh Parvin Pasalar Ali Aminian |
| author_sort | Fezzeh Elyasinia |
| collection | DOAJ |
| description | Background: Superoxide radicals are produced during oxidative metabolic processes, and removed by superoxide dismutase (SOD) enzymes. Controversial results have been reported regarding the tissue and plasma concentration of SOD in patients with breast cancer.
Methods: Venous blood was obtained from study participants and activity of SOD enzyme was determined in 100 women. Comparison was made between 50 patients with breast cancer and 50 individuals in control group.
Results: The activities of SOD in patients with malignancy and control group were 553.56±53.67 U/gr Hb and 1218.60±98.55 U/gr Hb, respectively (P <0.001). Patients with higher stage and nuclear grade had lower SOD activity.
Conclusions: lower levels of SOD activity was observed in women with breast cancer compared to healthy individuals. Considering the existing controversy regarding the SOD level in breast cancer patients, further studies to explore the reason of these differences are warranted. |
| first_indexed | 2024-12-14T04:45:56Z |
| format | Article |
| id | doaj.art-446f79ef76da4ba89f9bdf35ab0780ed |
| institution | Directory Open Access Journal |
| issn | 2383-0433 |
| language | English |
| last_indexed | 2024-12-14T04:45:56Z |
| publishDate | 2014-08-01 |
| publisher | Kaviani Breast Disease Institute |
| record_format | Article |
| series | Archives of Breast Cancer |
| spelling | doaj.art-446f79ef76da4ba89f9bdf35ab0780ed2022-12-21T23:16:40ZengKaviani Breast Disease InstituteArchives of Breast Cancer2383-04332014-08-011210.19187/abc.20141269-726Superoxide Dismutase Activities in Plasma of Patients with Breast CancerFezzeh Elyasinia0Venus Chegini1Asieh Olfat-Bakhsh2Parvin Pasalar3Ali Aminian4Department of Surgery, Tehran University of Medical Sciences, Tehran, IranDepartment of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, IranBreast Cancer Research group, Iranian Academic Center for Education, Culture and Research, Tehran, IranDepartment of Biochemistry, Tehran University of Medical Sciences, Tehran, IranBariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio, USBackground: Superoxide radicals are produced during oxidative metabolic processes, and removed by superoxide dismutase (SOD) enzymes. Controversial results have been reported regarding the tissue and plasma concentration of SOD in patients with breast cancer. Methods: Venous blood was obtained from study participants and activity of SOD enzyme was determined in 100 women. Comparison was made between 50 patients with breast cancer and 50 individuals in control group. Results: The activities of SOD in patients with malignancy and control group were 553.56±53.67 U/gr Hb and 1218.60±98.55 U/gr Hb, respectively (P <0.001). Patients with higher stage and nuclear grade had lower SOD activity. Conclusions: lower levels of SOD activity was observed in women with breast cancer compared to healthy individuals. Considering the existing controversy regarding the SOD level in breast cancer patients, further studies to explore the reason of these differences are warranted.https://archbreastcancer.com/index.php/abc/article/view/6Superoxide radicalsoxidative stresssuperoxide dismutase |
| spellingShingle | Fezzeh Elyasinia Venus Chegini Asieh Olfat-Bakhsh Parvin Pasalar Ali Aminian Superoxide Dismutase Activities in Plasma of Patients with Breast Cancer Archives of Breast Cancer Superoxide radicals oxidative stress superoxide dismutase |
| title | Superoxide Dismutase Activities in Plasma of Patients with Breast Cancer |
| title_full | Superoxide Dismutase Activities in Plasma of Patients with Breast Cancer |
| title_fullStr | Superoxide Dismutase Activities in Plasma of Patients with Breast Cancer |
| title_full_unstemmed | Superoxide Dismutase Activities in Plasma of Patients with Breast Cancer |
| title_short | Superoxide Dismutase Activities in Plasma of Patients with Breast Cancer |
| title_sort | superoxide dismutase activities in plasma of patients with breast cancer |
| topic | Superoxide radicals oxidative stress superoxide dismutase |
| url | https://archbreastcancer.com/index.php/abc/article/view/6 |
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