Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy
Surgical treatment of pharmacoresistant temporal lobe epilepsy (TLE) carries risks for language function that can significantly affect the quality of life. Predicting the risks of decline in language functions before surgery is, consequently, just as important as predicting the chances of becoming s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.884730/full |
| _version_ | 1797393318815989760 |
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| author | Andreu Massot-Tarrús Seyed M. Mirsattari Seyed M. Mirsattari Seyed M. Mirsattari Seyed M. Mirsattari |
| author_facet | Andreu Massot-Tarrús Seyed M. Mirsattari Seyed M. Mirsattari Seyed M. Mirsattari Seyed M. Mirsattari |
| author_sort | Andreu Massot-Tarrús |
| collection | DOAJ |
| description | Surgical treatment of pharmacoresistant temporal lobe epilepsy (TLE) carries risks for language function that can significantly affect the quality of life. Predicting the risks of decline in language functions before surgery is, consequently, just as important as predicting the chances of becoming seizure-free. The intracarotid amobarbital test, generally known as the Wada test (WT), has been traditionally used to determine language lateralization and to estimate their potential decline after surgery. However, the test is invasive and it does not localize the language functions. Therefore, other noninvasive methods have been proposed, of which functional magnetic resonance (fMRI) has the greatest potential. Functional MRI allows localization of language areas. It has good concordance with the WT for language lateralization, and it is of predictive value for postsurgical naming outcomes. Consequently, fMRI has progressively replaced WT for presurgical language evaluation. The objective of this manuscript is to review the most relevant aspects of language functions in TLE and the current role of fMRI and WT in the presurgical evaluation of language. First, we will provide context by revising the language network distribution and the effects of TLE on them. Then, we will assess the functional outcomes following various forms of TLE surgery and measures to reduce postoperative language decline. Finally, we will discuss the current indications for WT and fMRI and the potential usefulness of the resting-state fMRI technique. |
| first_indexed | 2024-03-09T00:01:47Z |
| format | Article |
| id | doaj.art-44717c2f958245e4b68ed4412d1c1048 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-09T00:01:47Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-44717c2f958245e4b68ed4412d1c10482023-12-12T16:48:24ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-09-011310.3389/fneur.2022.884730884730Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsyAndreu Massot-Tarrús0Seyed M. Mirsattari1Seyed M. Mirsattari2Seyed M. Mirsattari3Seyed M. Mirsattari4Department of Neurology, F. Ass. Mútua Terrassa, Terrassa, SpainDepartment of Clinical Neurological Sciences, Western University, London, ON, CanadaDepartment of Medical Biophysics, Western University, London, ON, CanadaDepartment of Medical Imaging, Western University, London, ON, CanadaDepartment of Psychology, Western University, London, ON, CanadaSurgical treatment of pharmacoresistant temporal lobe epilepsy (TLE) carries risks for language function that can significantly affect the quality of life. Predicting the risks of decline in language functions before surgery is, consequently, just as important as predicting the chances of becoming seizure-free. The intracarotid amobarbital test, generally known as the Wada test (WT), has been traditionally used to determine language lateralization and to estimate their potential decline after surgery. However, the test is invasive and it does not localize the language functions. Therefore, other noninvasive methods have been proposed, of which functional magnetic resonance (fMRI) has the greatest potential. Functional MRI allows localization of language areas. It has good concordance with the WT for language lateralization, and it is of predictive value for postsurgical naming outcomes. Consequently, fMRI has progressively replaced WT for presurgical language evaluation. The objective of this manuscript is to review the most relevant aspects of language functions in TLE and the current role of fMRI and WT in the presurgical evaluation of language. First, we will provide context by revising the language network distribution and the effects of TLE on them. Then, we will assess the functional outcomes following various forms of TLE surgery and measures to reduce postoperative language decline. Finally, we will discuss the current indications for WT and fMRI and the potential usefulness of the resting-state fMRI technique.https://www.frontiersin.org/articles/10.3389/fneur.2022.884730/fullintracarotid amobarbital testfunctional MRIresting-stateepilepsy surgerynamingoutcome |
| spellingShingle | Andreu Massot-Tarrús Seyed M. Mirsattari Seyed M. Mirsattari Seyed M. Mirsattari Seyed M. Mirsattari Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy Frontiers in Neurology intracarotid amobarbital test functional MRI resting-state epilepsy surgery naming outcome |
| title | Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy |
| title_full | Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy |
| title_fullStr | Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy |
| title_full_unstemmed | Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy |
| title_short | Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy |
| title_sort | roles of fmri and wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy |
| topic | intracarotid amobarbital test functional MRI resting-state epilepsy surgery naming outcome |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.884730/full |
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