Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders
Abstract It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted. Its endocrine functions came first to light when it was realized that osteoblasts, the bone forming cells, maintain energy homeostasis by improving glucose metabolism, insulin sensitivity and ener...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | Molecular Brain |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13041-019-0444-5 |
| _version_ | 1818543881596174336 |
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| author | Chang Shan Arijit Ghosh Xing-zhi Guo Shu-min Wang Yan-fang Hou Sheng-tian Li Jian-min Liu |
| author_facet | Chang Shan Arijit Ghosh Xing-zhi Guo Shu-min Wang Yan-fang Hou Sheng-tian Li Jian-min Liu |
| author_sort | Chang Shan |
| collection | DOAJ |
| description | Abstract It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted. Its endocrine functions came first to light when it was realized that osteoblasts, the bone forming cells, maintain energy homeostasis by improving glucose metabolism, insulin sensitivity and energy expenditure through osteocalcin, a multipurpose osteokine secreted by osteoblasts. Recently, the emerging knowledge on the functional aspects of this osteokine expanded to properties including adult and maternal regulation of cognitive functions. Therapeutic potential of this osteokine has also been recently reported in experimental Parkinson’s disease models. This review highlights such findings on the functions of osteocalcin in the brain and emphasizes on exploring and analyzing much more in-depth basic and clinical studies. |
| first_indexed | 2024-12-11T22:41:11Z |
| format | Article |
| id | doaj.art-447260e0d51d41a0a73e9af13c12ea52 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-12-11T22:41:11Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-447260e0d51d41a0a73e9af13c12ea522022-12-22T00:47:48ZengBMCMolecular Brain1756-66062019-03-0112111110.1186/s13041-019-0444-5Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disordersChang Shan0Arijit Ghosh1Xing-zhi Guo2Shu-min Wang3Yan-fang Hou4Sheng-tian Li5Jian-min Liu6Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic DiseasesBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong UniversityDepartment of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic DiseasesDepartment of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic DiseasesDepartment of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic DiseasesBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong UniversityDepartment of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic DiseasesAbstract It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted. Its endocrine functions came first to light when it was realized that osteoblasts, the bone forming cells, maintain energy homeostasis by improving glucose metabolism, insulin sensitivity and energy expenditure through osteocalcin, a multipurpose osteokine secreted by osteoblasts. Recently, the emerging knowledge on the functional aspects of this osteokine expanded to properties including adult and maternal regulation of cognitive functions. Therapeutic potential of this osteokine has also been recently reported in experimental Parkinson’s disease models. This review highlights such findings on the functions of osteocalcin in the brain and emphasizes on exploring and analyzing much more in-depth basic and clinical studies.http://link.springer.com/article/10.1186/s13041-019-0444-5BehaviorBoneBrainCognitionOsteocalcinParkinson’s disease |
| spellingShingle | Chang Shan Arijit Ghosh Xing-zhi Guo Shu-min Wang Yan-fang Hou Sheng-tian Li Jian-min Liu Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders Molecular Brain Behavior Bone Brain Cognition Osteocalcin Parkinson’s disease |
| title | Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders |
| title_full | Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders |
| title_fullStr | Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders |
| title_full_unstemmed | Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders |
| title_short | Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders |
| title_sort | roles for osteocalcin in brain signalling implications in cognition and motor related disorders |
| topic | Behavior Bone Brain Cognition Osteocalcin Parkinson’s disease |
| url | http://link.springer.com/article/10.1186/s13041-019-0444-5 |
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