P7.13 RELATION OF PARAMETERS OF VASCULAR STIFFNESS TO CARDIAC STRUCTURE AND FUNCTION IN PATIENTS AT RISK OF OR WITH TYPE 2 DIABETES
Objective: To investigate the relationship between arterial function and cardiac, especially left ventricular (LV) diastolic, function, in people at risk of or with type 2 diabetes (T2DM). Design and method: 64 patients (48% non-European) participated in the study. Cardiac indices were obtained by...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2015-11-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930678/view |
| _version_ | 1818247468126568448 |
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| author | Luca Faconti* Charlotte E. Mills Virginia Govoni Maria L. Casagrande Andrew J. Webb Kennedy J. Cruickshank |
| author_facet | Luca Faconti* Charlotte E. Mills Virginia Govoni Maria L. Casagrande Andrew J. Webb Kennedy J. Cruickshank |
| author_sort | Luca Faconti* |
| collection | DOAJ |
| description | Objective: To investigate the relationship between arterial function and cardiac, especially left ventricular (LV) diastolic, function, in people at risk of or with type 2 diabetes (T2DM).
Design and method: 64 patients (48% non-European) participated in the study. Cardiac indices were obtained by 2-dimensional echocardiography, aortic pulse wave velocity (PWV) and augmentation index (AIx) were measured with an Arteriograph, cardio ankle vascular index (CAVI), nominally independent of pressure, was obtained using a VaSera device.
Results: Mean age was 59 y, 83% with T2DM, 84% hypertension, 12% previous cardiovascular events. Regressions for AIx with LV mass index (mean 51.2 g/m2.7) and left atrium volume index (β(SE)) were 0.52 (0.16) and 1.43 (0.4), p<0.002. Tissue Doppler indices (TDI) of diastolic function, E′ septal and E′ lateral waves were inversely related with AIx (−2.94 (0.9) and −2.14 (0.8)) as they were with CAVI (left, −0.2 (0.07) and −0.27 (0.05)) (all p<0.01), but the E/E′ ratio was not. Similarly, TDI for systolic function, S′, was related with AIx (−3.7 (1.1)) and with CAVI (0.21 (0.1))(p<0.05). In multiple regression models these relationships were still significant, when including age, gender, BMI, diabetic status and ethnicity, for cardiac structure and function (p<0.05), as with CAVI measures (p<0.05). There was no relationship with aortic PWV.
Conclusion: In patients at risk of or with T2DM, pressure augmentation is related to cardiac remodeling and diastolic function while a mainly pressure-independent index of stiffness of the aorta, femoral and tibial artery (CAVI) is associated with TDI of diastolic function. |
| first_indexed | 2024-12-12T15:05:11Z |
| format | Article |
| id | doaj.art-447487573fa64fc48cac6d135c599871 |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-12-12T15:05:11Z |
| publishDate | 2015-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-447487573fa64fc48cac6d135c5998712022-12-22T00:20:45ZengBMCArtery Research1876-44012015-11-011210.1016/j.artres.2015.10.316P7.13 RELATION OF PARAMETERS OF VASCULAR STIFFNESS TO CARDIAC STRUCTURE AND FUNCTION IN PATIENTS AT RISK OF OR WITH TYPE 2 DIABETESLuca Faconti*Charlotte E. MillsVirginia GovoniMaria L. CasagrandeAndrew J. WebbKennedy J. CruickshankObjective: To investigate the relationship between arterial function and cardiac, especially left ventricular (LV) diastolic, function, in people at risk of or with type 2 diabetes (T2DM). Design and method: 64 patients (48% non-European) participated in the study. Cardiac indices were obtained by 2-dimensional echocardiography, aortic pulse wave velocity (PWV) and augmentation index (AIx) were measured with an Arteriograph, cardio ankle vascular index (CAVI), nominally independent of pressure, was obtained using a VaSera device. Results: Mean age was 59 y, 83% with T2DM, 84% hypertension, 12% previous cardiovascular events. Regressions for AIx with LV mass index (mean 51.2 g/m2.7) and left atrium volume index (β(SE)) were 0.52 (0.16) and 1.43 (0.4), p<0.002. Tissue Doppler indices (TDI) of diastolic function, E′ septal and E′ lateral waves were inversely related with AIx (−2.94 (0.9) and −2.14 (0.8)) as they were with CAVI (left, −0.2 (0.07) and −0.27 (0.05)) (all p<0.01), but the E/E′ ratio was not. Similarly, TDI for systolic function, S′, was related with AIx (−3.7 (1.1)) and with CAVI (0.21 (0.1))(p<0.05). In multiple regression models these relationships were still significant, when including age, gender, BMI, diabetic status and ethnicity, for cardiac structure and function (p<0.05), as with CAVI measures (p<0.05). There was no relationship with aortic PWV. Conclusion: In patients at risk of or with T2DM, pressure augmentation is related to cardiac remodeling and diastolic function while a mainly pressure-independent index of stiffness of the aorta, femoral and tibial artery (CAVI) is associated with TDI of diastolic function.https://www.atlantis-press.com/article/125930678/view |
| spellingShingle | Luca Faconti* Charlotte E. Mills Virginia Govoni Maria L. Casagrande Andrew J. Webb Kennedy J. Cruickshank P7.13 RELATION OF PARAMETERS OF VASCULAR STIFFNESS TO CARDIAC STRUCTURE AND FUNCTION IN PATIENTS AT RISK OF OR WITH TYPE 2 DIABETES Artery Research |
| title | P7.13 RELATION OF PARAMETERS OF VASCULAR STIFFNESS TO CARDIAC STRUCTURE AND FUNCTION IN PATIENTS AT RISK OF OR WITH TYPE 2 DIABETES |
| title_full | P7.13 RELATION OF PARAMETERS OF VASCULAR STIFFNESS TO CARDIAC STRUCTURE AND FUNCTION IN PATIENTS AT RISK OF OR WITH TYPE 2 DIABETES |
| title_fullStr | P7.13 RELATION OF PARAMETERS OF VASCULAR STIFFNESS TO CARDIAC STRUCTURE AND FUNCTION IN PATIENTS AT RISK OF OR WITH TYPE 2 DIABETES |
| title_full_unstemmed | P7.13 RELATION OF PARAMETERS OF VASCULAR STIFFNESS TO CARDIAC STRUCTURE AND FUNCTION IN PATIENTS AT RISK OF OR WITH TYPE 2 DIABETES |
| title_short | P7.13 RELATION OF PARAMETERS OF VASCULAR STIFFNESS TO CARDIAC STRUCTURE AND FUNCTION IN PATIENTS AT RISK OF OR WITH TYPE 2 DIABETES |
| title_sort | p7 13 relation of parameters of vascular stiffness to cardiac structure and function in patients at risk of or with type 2 diabetes |
| url | https://www.atlantis-press.com/article/125930678/view |
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