Subconjunctival bevacizumab injection versus mitomycin C application after primary pterygium surgery
Purpose The aim of this study was to compare subconjunctival bevacizumab injection and mitomycin C (MMC) application after primary pterygium surgery in terms of recurrence rates and complications. Patients and methods This prospective comparative clinical study included 90 eyes of 90 patients with p...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Delta Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.djo.eg.net/article.asp?issn=1110-9173;year=2019;volume=20;issue=4;spage=139;epage=143;aulast=Albialy |
| _version_ | 1818588462352171008 |
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| author | Hani A Albialy Haitham Y Al-Nashar |
| author_facet | Hani A Albialy Haitham Y Al-Nashar |
| author_sort | Hani A Albialy |
| collection | DOAJ |
| description | Purpose The aim of this study was to compare subconjunctival bevacizumab injection and mitomycin C (MMC) application after primary pterygium surgery in terms of recurrence rates and complications.
Patients and methods This prospective comparative clinical study included 90 eyes of 90 patients with primary pterygium who underwent excision with bare sclera technique. Patients were randomized into three groups: group A (30 eyes), in which MMC 0.02% was applied to the bare scleral area for 3 min; group B (30 eyes), which received 2.5 mg/0.1 ml subconjunctival bevacizumab injection at the end of surgery; and group C (30 eyes), which was used as a control group and did not receive any adjuvant medications after pterygium excision. Patients were followed up for 6 months, and the recurrence rates of pterygium and any complications were reported.
Results At 6 months after surgery, the recurrence rates in the three groups were as follows: two (6.7%) eyes in the MMC group A, two (6.7%) eyes in the bevacizumab group B, and 11 (36.7%) eyes in the control group C, with a significant difference among groups (P=0.01). No serious complications, except subconjunctival hemorrhage, were observed in all groups.
Conclusion Groups receiving topical 0.02% MMC and 2.5 mg/0.1 ml subconjunctival bevacizumab injections after surgery showed lower recurrence rates than the control group. However, no difference in the recurrence rate was observed between both groups. |
| first_indexed | 2024-12-16T09:25:08Z |
| format | Article |
| id | doaj.art-44795f7b79b74523ace4cf49c6cb14ff |
| institution | Directory Open Access Journal |
| issn | 1110-9173 2090-4835 |
| language | English |
| last_indexed | 2024-12-16T09:25:08Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Delta Journal of Ophthalmology |
| spelling | doaj.art-44795f7b79b74523ace4cf49c6cb14ff2022-12-21T22:36:39ZengWolters Kluwer Medknow PublicationsDelta Journal of Ophthalmology1110-91732090-48352019-01-0120413914310.4103/DJO.DJO_20_19Subconjunctival bevacizumab injection versus mitomycin C application after primary pterygium surgeryHani A AlbialyHaitham Y Al-NasharPurpose The aim of this study was to compare subconjunctival bevacizumab injection and mitomycin C (MMC) application after primary pterygium surgery in terms of recurrence rates and complications. Patients and methods This prospective comparative clinical study included 90 eyes of 90 patients with primary pterygium who underwent excision with bare sclera technique. Patients were randomized into three groups: group A (30 eyes), in which MMC 0.02% was applied to the bare scleral area for 3 min; group B (30 eyes), which received 2.5 mg/0.1 ml subconjunctival bevacizumab injection at the end of surgery; and group C (30 eyes), which was used as a control group and did not receive any adjuvant medications after pterygium excision. Patients were followed up for 6 months, and the recurrence rates of pterygium and any complications were reported. Results At 6 months after surgery, the recurrence rates in the three groups were as follows: two (6.7%) eyes in the MMC group A, two (6.7%) eyes in the bevacizumab group B, and 11 (36.7%) eyes in the control group C, with a significant difference among groups (P=0.01). No serious complications, except subconjunctival hemorrhage, were observed in all groups. Conclusion Groups receiving topical 0.02% MMC and 2.5 mg/0.1 ml subconjunctival bevacizumab injections after surgery showed lower recurrence rates than the control group. However, no difference in the recurrence rate was observed between both groups.http://www.djo.eg.net/article.asp?issn=1110-9173;year=2019;volume=20;issue=4;spage=139;epage=143;aulast=Albialybevacizumabmitomycin cprimary pterygiumrecurrence |
| spellingShingle | Hani A Albialy Haitham Y Al-Nashar Subconjunctival bevacizumab injection versus mitomycin C application after primary pterygium surgery Delta Journal of Ophthalmology bevacizumab mitomycin c primary pterygium recurrence |
| title | Subconjunctival bevacizumab injection versus mitomycin C application after primary pterygium surgery |
| title_full | Subconjunctival bevacizumab injection versus mitomycin C application after primary pterygium surgery |
| title_fullStr | Subconjunctival bevacizumab injection versus mitomycin C application after primary pterygium surgery |
| title_full_unstemmed | Subconjunctival bevacizumab injection versus mitomycin C application after primary pterygium surgery |
| title_short | Subconjunctival bevacizumab injection versus mitomycin C application after primary pterygium surgery |
| title_sort | subconjunctival bevacizumab injection versus mitomycin c application after primary pterygium surgery |
| topic | bevacizumab mitomycin c primary pterygium recurrence |
| url | http://www.djo.eg.net/article.asp?issn=1110-9173;year=2019;volume=20;issue=4;spage=139;epage=143;aulast=Albialy |
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