The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis
Abstract Background Although accumulating data have suggested the development of cancer in systemic lupus erythematosus (SLE) patients, these results remain inconsistent. To examine such a putative association, this analysis reports the association between SLE and the risks of 24 cancer types. Metho...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-12-01
|
| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13075-018-1760-3 |
| _version_ | 1819067612714237952 |
|---|---|
| author | Lebin Song Yi Wang Jiayi Zhang Ninghong Song Xiaoyun Xu Yan Lu |
| author_facet | Lebin Song Yi Wang Jiayi Zhang Ninghong Song Xiaoyun Xu Yan Lu |
| author_sort | Lebin Song |
| collection | DOAJ |
| description | Abstract Background Although accumulating data have suggested the development of cancer in systemic lupus erythematosus (SLE) patients, these results remain inconsistent. To examine such a putative association, this analysis reports the association between SLE and the risks of 24 cancer types. Methods Online databases PubMed, EMBASE, and Web of Science were searched comprehensively for eligible studies, published up to 15 May 2018. Pooled standardized incidence rates (SIRs) with 95% confidence intervals (CIs) were utilized to reveal their associations. Results A total of 24 eligible studies were ultimately enrolled. Our results indicated that SLE was associated with increased risk of overall cancers, cancer risk in both genders, non-Hodgkin’s lymphoma, Hodgkin’s lymphoma, leukemia, multiple myeloma, cervix, vagina/vulva, renal, bladder, esophagus, gastric, hepatobiliary, lung, oropharynx, larynx, non-melanoma skin, and thyroid cancers. Additionally, SLE could reduce the risk of prostate cancer and cutaneous melanoma; however, it was not significantly associated with breast, uterus, ovarian, pancreatic, colorectal, or brain cancers. Conclusions Our results shed light SLE being correlated with increased risk for 16 involved cancers and decreased risk for prostate cancer and cutaneous melanoma. This comprehensive meta-analysis provides epidemiological evidence supporting the associations between SLE and cancer risk. This evidence could be utilized to drive public policies and to help guide personalized medicine to better manage SLE and reduce associated cancer morbidity and mortality. |
| first_indexed | 2024-12-21T16:21:02Z |
| format | Article |
| id | doaj.art-4479a0767ec94be6a05d5637e56a0997 |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-12-21T16:21:02Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-4479a0767ec94be6a05d5637e56a09972022-12-21T18:57:33ZengBMCArthritis Research & Therapy1478-63622018-12-0120111310.1186/s13075-018-1760-3The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysisLebin Song0Yi Wang1Jiayi Zhang2Ninghong Song3Xiaoyun Xu4Yan Lu5Department of Dermatology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Dermatology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Dermatology, The First Affiliated Hospital of Nanjing Medical UniversityAbstract Background Although accumulating data have suggested the development of cancer in systemic lupus erythematosus (SLE) patients, these results remain inconsistent. To examine such a putative association, this analysis reports the association between SLE and the risks of 24 cancer types. Methods Online databases PubMed, EMBASE, and Web of Science were searched comprehensively for eligible studies, published up to 15 May 2018. Pooled standardized incidence rates (SIRs) with 95% confidence intervals (CIs) were utilized to reveal their associations. Results A total of 24 eligible studies were ultimately enrolled. Our results indicated that SLE was associated with increased risk of overall cancers, cancer risk in both genders, non-Hodgkin’s lymphoma, Hodgkin’s lymphoma, leukemia, multiple myeloma, cervix, vagina/vulva, renal, bladder, esophagus, gastric, hepatobiliary, lung, oropharynx, larynx, non-melanoma skin, and thyroid cancers. Additionally, SLE could reduce the risk of prostate cancer and cutaneous melanoma; however, it was not significantly associated with breast, uterus, ovarian, pancreatic, colorectal, or brain cancers. Conclusions Our results shed light SLE being correlated with increased risk for 16 involved cancers and decreased risk for prostate cancer and cutaneous melanoma. This comprehensive meta-analysis provides epidemiological evidence supporting the associations between SLE and cancer risk. This evidence could be utilized to drive public policies and to help guide personalized medicine to better manage SLE and reduce associated cancer morbidity and mortality.http://link.springer.com/article/10.1186/s13075-018-1760-3Systemic lupus erythematosusCancerMeta-analysis |
| spellingShingle | Lebin Song Yi Wang Jiayi Zhang Ninghong Song Xiaoyun Xu Yan Lu The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis Arthritis Research & Therapy Systemic lupus erythematosus Cancer Meta-analysis |
| title | The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis |
| title_full | The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis |
| title_fullStr | The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis |
| title_full_unstemmed | The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis |
| title_short | The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis |
| title_sort | risks of cancer development in systemic lupus erythematosus sle patients a systematic review and meta analysis |
| topic | Systemic lupus erythematosus Cancer Meta-analysis |
| url | http://link.springer.com/article/10.1186/s13075-018-1760-3 |
| work_keys_str_mv | AT lebinsong therisksofcancerdevelopmentinsystemiclupuserythematosusslepatientsasystematicreviewandmetaanalysis AT yiwang therisksofcancerdevelopmentinsystemiclupuserythematosusslepatientsasystematicreviewandmetaanalysis AT jiayizhang therisksofcancerdevelopmentinsystemiclupuserythematosusslepatientsasystematicreviewandmetaanalysis AT ninghongsong therisksofcancerdevelopmentinsystemiclupuserythematosusslepatientsasystematicreviewandmetaanalysis AT xiaoyunxu therisksofcancerdevelopmentinsystemiclupuserythematosusslepatientsasystematicreviewandmetaanalysis AT yanlu therisksofcancerdevelopmentinsystemiclupuserythematosusslepatientsasystematicreviewandmetaanalysis AT lebinsong risksofcancerdevelopmentinsystemiclupuserythematosusslepatientsasystematicreviewandmetaanalysis AT yiwang risksofcancerdevelopmentinsystemiclupuserythematosusslepatientsasystematicreviewandmetaanalysis AT jiayizhang risksofcancerdevelopmentinsystemiclupuserythematosusslepatientsasystematicreviewandmetaanalysis AT ninghongsong risksofcancerdevelopmentinsystemiclupuserythematosusslepatientsasystematicreviewandmetaanalysis AT xiaoyunxu risksofcancerdevelopmentinsystemiclupuserythematosusslepatientsasystematicreviewandmetaanalysis AT yanlu risksofcancerdevelopmentinsystemiclupuserythematosusslepatientsasystematicreviewandmetaanalysis |