An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity
Objective: Examine white blood cell (WBC) proportions across preeclamptic (n = 28 cases) and normotensive (n = 28 controls) pregnancy in individuals with overweight/obesity. Methods: WBC proportions were inferred from genome-wide DNA methylation data and compared by case/control status and self-iden...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-10-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2021.1987453 |
| _version_ | 1797681507478798336 |
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| author | Mitali Ray Lacey W. Heinsberg Yvette P. Conley James M. Roberts Arun Jeyabalan Carl A. Hubel Daniel E. Weeks Mandy J. Schmella |
| author_facet | Mitali Ray Lacey W. Heinsberg Yvette P. Conley James M. Roberts Arun Jeyabalan Carl A. Hubel Daniel E. Weeks Mandy J. Schmella |
| author_sort | Mitali Ray |
| collection | DOAJ |
| description | Objective: Examine white blood cell (WBC) proportions across preeclamptic (n = 28 cases) and normotensive (n = 28 controls) pregnancy in individuals with overweight/obesity. Methods: WBC proportions were inferred from genome-wide DNA methylation data and compared by case/control status and self-identified race. Results: In Trimester 1, ean B cell proportions were suggestively lower in cases in the overall sample and significantly lower in White participants but not in Black participants. More significant WBC proportion changes were observed across normotensive than preeclamptic pregnancy. Conclusions: These findings in a small sample demonstrate need for additional studies investigating the relationship between self-identified race and WBCs in pregnancy. |
| first_indexed | 2024-03-11T23:45:48Z |
| format | Article |
| id | doaj.art-447addb74d7e4940a3e0636e48815149 |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:45:48Z |
| publishDate | 2021-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-447addb74d7e4940a3e0636e488151492023-09-19T09:24:44ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652021-10-0140431232110.1080/10641955.2021.19874531987453An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesityMitali Ray0Lacey W. Heinsberg1Yvette P. Conley2James M. Roberts3Arun Jeyabalan4Carl A. Hubel5Daniel E. Weeks6Mandy J. Schmella7University of PittsburghUniversity of PittsburghUniversity of PittsburghUniversity of PittsburghUniversity of PittsburghUniversity of PittsburghUniversity of PittsburghUniversity of PittsburghObjective: Examine white blood cell (WBC) proportions across preeclamptic (n = 28 cases) and normotensive (n = 28 controls) pregnancy in individuals with overweight/obesity. Methods: WBC proportions were inferred from genome-wide DNA methylation data and compared by case/control status and self-identified race. Results: In Trimester 1, ean B cell proportions were suggestively lower in cases in the overall sample and significantly lower in White participants but not in Black participants. More significant WBC proportion changes were observed across normotensive than preeclamptic pregnancy. Conclusions: These findings in a small sample demonstrate need for additional studies investigating the relationship between self-identified race and WBCs in pregnancy.http://dx.doi.org/10.1080/10641955.2021.1987453preeclampsiawhite blood cellwbc counthypertension in pregnancydna methylation |
| spellingShingle | Mitali Ray Lacey W. Heinsberg Yvette P. Conley James M. Roberts Arun Jeyabalan Carl A. Hubel Daniel E. Weeks Mandy J. Schmella An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity Hypertension in Pregnancy preeclampsia white blood cell wbc count hypertension in pregnancy dna methylation |
| title | An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity |
| title_full | An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity |
| title_fullStr | An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity |
| title_full_unstemmed | An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity |
| title_short | An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity |
| title_sort | exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self identified race in individuals with overweight or obesity |
| topic | preeclampsia white blood cell wbc count hypertension in pregnancy dna methylation |
| url | http://dx.doi.org/10.1080/10641955.2021.1987453 |
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