The efficacy and safety of topical 10% potassium hydroxide for molluscum contagiosum: a systematic review and meta-analysis
Background Molluscum contagiosum (MC) is a self-limited cutaneous viral infection. Topical 10% potassium hydroxide (KOH) has been used for treating MC. However, it remains unclear whether it is beneficial or not to apply topical 10% KOH for treating MC. Methods To confirm the efficacy and safety of...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-04-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2021.1898527 |
| _version_ | 1797683527796391936 |
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| author | Jae Young Heo Tae Heum Park Woo Il Kim |
| author_facet | Jae Young Heo Tae Heum Park Woo Il Kim |
| author_sort | Jae Young Heo |
| collection | DOAJ |
| description | Background Molluscum contagiosum (MC) is a self-limited cutaneous viral infection. Topical 10% potassium hydroxide (KOH) has been used for treating MC. However, it remains unclear whether it is beneficial or not to apply topical 10% KOH for treating MC. Methods To confirm the efficacy and safety of topical 10% KOH compared with placebo as well as other treatments for MC, meta-analysis was used. Up to September 2020, we performed a comprehensive search of literature based on three databases with following keywords including ‘molluscum contagiosum’ and ‘potassium hydroxide’. Results Our meta-analyses demonstrated a significant difference between topical 10% KOH and placebo for complete clearance of MC (RR: 2.96, 95% CI: 1.69 − 5.17, p = .0001), while there were no statistical differences between them in the number of patients with adverse events (RR: 1.73, 95% CI: 0.67 − 4.45, p = .2562). Also, topical 10% KOH was as effective as mechanical treatments for MC (RR: 0.95, 95% CI: 0.84 − 1.07, p = .3833). Conclusion We demonstrate that application of topical 10% KOH may be one of effective and appropriate methods for the treatment of MC compared with awaiting spontaneous resolution due to its safety and effectiveness. |
| first_indexed | 2024-03-12T00:15:51Z |
| format | Article |
| id | doaj.art-447d62f118564fedbfd2571ec5945b35 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:15:51Z |
| publishDate | 2022-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-447d62f118564fedbfd2571ec5945b352023-09-15T14:28:50ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-04-013331682169010.1080/09546634.2021.18985271898527The efficacy and safety of topical 10% potassium hydroxide for molluscum contagiosum: a systematic review and meta-analysisJae Young Heo0Tae Heum Park1Woo Il Kim2Department of Dermatology, Soonchunhyang University HospitalDepartment of Dermatology, Soonchunhyang University HospitalDepartment of Dermatology, Soonchunhyang University HospitalBackground Molluscum contagiosum (MC) is a self-limited cutaneous viral infection. Topical 10% potassium hydroxide (KOH) has been used for treating MC. However, it remains unclear whether it is beneficial or not to apply topical 10% KOH for treating MC. Methods To confirm the efficacy and safety of topical 10% KOH compared with placebo as well as other treatments for MC, meta-analysis was used. Up to September 2020, we performed a comprehensive search of literature based on three databases with following keywords including ‘molluscum contagiosum’ and ‘potassium hydroxide’. Results Our meta-analyses demonstrated a significant difference between topical 10% KOH and placebo for complete clearance of MC (RR: 2.96, 95% CI: 1.69 − 5.17, p = .0001), while there were no statistical differences between them in the number of patients with adverse events (RR: 1.73, 95% CI: 0.67 − 4.45, p = .2562). Also, topical 10% KOH was as effective as mechanical treatments for MC (RR: 0.95, 95% CI: 0.84 − 1.07, p = .3833). Conclusion We demonstrate that application of topical 10% KOH may be one of effective and appropriate methods for the treatment of MC compared with awaiting spontaneous resolution due to its safety and effectiveness.http://dx.doi.org/10.1080/09546634.2021.1898527molluscum contagiosumpotassium hydroxideplacebo |
| spellingShingle | Jae Young Heo Tae Heum Park Woo Il Kim The efficacy and safety of topical 10% potassium hydroxide for molluscum contagiosum: a systematic review and meta-analysis Journal of Dermatological Treatment molluscum contagiosum potassium hydroxide placebo |
| title | The efficacy and safety of topical 10% potassium hydroxide for molluscum contagiosum: a systematic review and meta-analysis |
| title_full | The efficacy and safety of topical 10% potassium hydroxide for molluscum contagiosum: a systematic review and meta-analysis |
| title_fullStr | The efficacy and safety of topical 10% potassium hydroxide for molluscum contagiosum: a systematic review and meta-analysis |
| title_full_unstemmed | The efficacy and safety of topical 10% potassium hydroxide for molluscum contagiosum: a systematic review and meta-analysis |
| title_short | The efficacy and safety of topical 10% potassium hydroxide for molluscum contagiosum: a systematic review and meta-analysis |
| title_sort | efficacy and safety of topical 10 potassium hydroxide for molluscum contagiosum a systematic review and meta analysis |
| topic | molluscum contagiosum potassium hydroxide placebo |
| url | http://dx.doi.org/10.1080/09546634.2021.1898527 |
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