Prognostic Value of NTCP p.Ser267Phe Variant in Patients with Chronic Hepatitis B
Aim: In this study, the aim is to detect polymorphisms in the gene encoding the sodium taurocholate cotransporting polypeptide (NTCP), the functional receptor for hepatitis B virus (HBV) and hepatitis D virus. Materials and Methods: The study included a total of 293 patients, with 150 diagnosed with...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2024-03-01
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| Series: | Namık Kemal Tıp Dergisi |
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http://namikkemalmedj.com/archives/archive-detail/article-preview/prognostic-value-of-ntcp-pser267phe-variant-in-pat/64773
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| author | Bülent ÇAKAL Alp ATASOY Mehveş PODA Bilger ÇAVUŞ Mesut BULAKÇI Mine GÜLLÜOĞLU Filiz AKYÜZ |
| author_facet | Bülent ÇAKAL Alp ATASOY Mehveş PODA Bilger ÇAVUŞ Mesut BULAKÇI Mine GÜLLÜOĞLU Filiz AKYÜZ |
| author_sort | Bülent ÇAKAL |
| collection | DOAJ |
| description | Aim: In this study, the aim is to detect polymorphisms in the gene encoding the sodium taurocholate cotransporting polypeptide (NTCP), the functional receptor for hepatitis B virus (HBV) and hepatitis D virus. Materials and Methods: The study included a total of 293 patients, with 150 diagnosed with chronic hepatitis B (CHB) and 143 undergoing liver parenchyma biopsy procedures due to different clinical indications. Total DNA was isolated from liver biopsy samples. The TaqMan SNP genotyping method was used to determine the rs2296651 polymorphism in the SLC10A1 gene, which leads to the NTCP S267F variation. Results: In patients with CHB and the control group, the NTCP-interacting domain was highly conserved, and no variation of the SNP rs2296651 in the SLC10A1 gene leading to the NTCP S267F variation was detected in any of the patients. Conclusion: It was thought that in patients with CHB, the impact of the NTCP S267F variation on the progression of HBV-associated diseases and its influence on the therapeutic efficacy of anti-viral agents targeting NTCP blockade may be limited. |
| first_indexed | 2024-04-24T19:37:22Z |
| format | Article |
| id | doaj.art-447e47f753e44029a89bbf3b41b8cd02 |
| institution | Directory Open Access Journal |
| issn | 2587-0262 |
| language | English |
| last_indexed | 2024-04-24T19:37:22Z |
| publishDate | 2024-03-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Namık Kemal Tıp Dergisi |
| spelling | doaj.art-447e47f753e44029a89bbf3b41b8cd022024-03-25T11:38:45ZengGalenos YayincilikNamık Kemal Tıp Dergisi2587-02622024-03-01121343910.4274/nkmj.galenos.2024.2612113049054Prognostic Value of NTCP p.Ser267Phe Variant in Patients with Chronic Hepatitis BBülent ÇAKAL0Alp ATASOY1Mehveş PODA2Bilger ÇAVUŞ3Mesut BULAKÇI4Mine GÜLLÜOĞLU5Filiz AKYÜZ6 İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye İstanbul Üniversitesi, İstanbul Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Gastroenterohepatoloji Bilim Dalı, İstanbul, Türkiye İstanbul Üniversitesi, Aziz Sancar Deneysel Tıp Araştırma Enstitüsü, Genetik Anabilim Dalı, İstanbul, Türkiye İstanbul Üniversitesi, İstanbul Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Gastroenterohepatoloji Bilim Dalı, İstanbul, Türkiye İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Radyoloji Anabilim Dalı, İstanbul, Türkiye İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye İstanbul Üniversitesi, İstanbul Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Gastroenterohepatoloji Bilim Dalı, İstanbul, Türkiye Aim: In this study, the aim is to detect polymorphisms in the gene encoding the sodium taurocholate cotransporting polypeptide (NTCP), the functional receptor for hepatitis B virus (HBV) and hepatitis D virus. Materials and Methods: The study included a total of 293 patients, with 150 diagnosed with chronic hepatitis B (CHB) and 143 undergoing liver parenchyma biopsy procedures due to different clinical indications. Total DNA was isolated from liver biopsy samples. The TaqMan SNP genotyping method was used to determine the rs2296651 polymorphism in the SLC10A1 gene, which leads to the NTCP S267F variation. Results: In patients with CHB and the control group, the NTCP-interacting domain was highly conserved, and no variation of the SNP rs2296651 in the SLC10A1 gene leading to the NTCP S267F variation was detected in any of the patients. Conclusion: It was thought that in patients with CHB, the impact of the NTCP S267F variation on the progression of HBV-associated diseases and its influence on the therapeutic efficacy of anti-viral agents targeting NTCP blockade may be limited. http://namikkemalmedj.com/archives/archive-detail/article-preview/prognostic-value-of-ntcp-pser267phe-variant-in-pat/64773 hepatitis b viruschronic hepatitis bsingle nucleotide polymorphismsodium taurocholate co-transporting polypeptide |
| spellingShingle | Bülent ÇAKAL Alp ATASOY Mehveş PODA Bilger ÇAVUŞ Mesut BULAKÇI Mine GÜLLÜOĞLU Filiz AKYÜZ Prognostic Value of NTCP p.Ser267Phe Variant in Patients with Chronic Hepatitis B Namık Kemal Tıp Dergisi hepatitis b virus chronic hepatitis b single nucleotide polymorphism sodium taurocholate co-transporting polypeptide |
| title | Prognostic Value of NTCP p.Ser267Phe Variant in Patients with Chronic Hepatitis B |
| title_full | Prognostic Value of NTCP p.Ser267Phe Variant in Patients with Chronic Hepatitis B |
| title_fullStr | Prognostic Value of NTCP p.Ser267Phe Variant in Patients with Chronic Hepatitis B |
| title_full_unstemmed | Prognostic Value of NTCP p.Ser267Phe Variant in Patients with Chronic Hepatitis B |
| title_short | Prognostic Value of NTCP p.Ser267Phe Variant in Patients with Chronic Hepatitis B |
| title_sort | prognostic value of ntcp p ser267phe variant in patients with chronic hepatitis b |
| topic | hepatitis b virus chronic hepatitis b single nucleotide polymorphism sodium taurocholate co-transporting polypeptide |
| url |
http://namikkemalmedj.com/archives/archive-detail/article-preview/prognostic-value-of-ntcp-pser267phe-variant-in-pat/64773
|
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