Development of a SPE-LC-MS Method for the Quantitation of Palbociclib and Abemaciclib in Human Plasma

Development of a SPE-LC-MS Method for the Quantitation of Palbociclib and Abemaciclib in Human Plasma

Palbociclib and abemaciclib are two cyclin-dependent kinases 4 and 6 used for breast cancer treatment. Levels of these medicines present a significant interindividual variability, so monitoring those concentrations might be necessary in therapy. Most of the methods presented so far in the literature...

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Bibliographic Details
Main Authors: Daniela Maria Calucică, Costel-Valentin Manda, Amelia Maria Găman, Ștefan Răileanu, Liliana Stanca, Monica Denisa Elena Popescu, Olivia Garofița Mateescu, Andrei Biță, Octavian Croitoru, Simona-Daniela Neamțu
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
palbociclib
abemaciclib
human plasma
SPE
LC-MS
Online Access:https://www.mdpi.com/1420-3049/27/23/8604

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